ES2095207T3 - Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn. - Google Patents
Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn.Info
- Publication number
- ES2095207T3 ES2095207T3 ES88403229T ES88403229T ES2095207T3 ES 2095207 T3 ES2095207 T3 ES 2095207T3 ES 88403229 T ES88403229 T ES 88403229T ES 88403229 T ES88403229 T ES 88403229T ES 2095207 T3 ES2095207 T3 ES 2095207T3
- Authority
- ES
- Spain
- Prior art keywords
- dna
- hap
- retinoic acid
- hepatoma
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- High Energy & Nuclear Physics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
SE EMPLEA LA INTEGRACION DE UN VIRUS DE HEPATITIS B (VHB) PREVIAMENTE AISLADO, EN UN FRAGMENTO DE DNA CELULAR 147 BP LIGADO AL CARCINOMA HEPATOCELULAR, COMO SONDA PARA CLONAR EL CORRESPONDIENTE DNA COMPLEMENTARIO DE UNA BIBLIOTECA DE CDNA DEL HIGADO HUMANO. EL ANALISIS DE LA SECUENCIA NUCLEOTIDICA REVELA QUE LA ESTRUCTURA TOTAL DEL GEN CELULAR, DESIGNADA HAP, ES SIMILAR A LA DE LOS RECEPTORES DE LA HORMONA QUE SE UNE AL DNA. 6 DE CADA 7 LINEAS CELULARES DEL HEPATOMA Y DERIVADAS DEL HEPATOMA EXPRESAN 2.5 KB DE ESPECIES DE MRNA HAP, INDETECTABLE ENEL HIGADO DE ADULTOS Y FETOS NORMALES, PERO PRESENTES EN TODOS LOS TEJIDOS NO - PEPTIDICOS ANALIZADOS. LAS EXPERIENCIAS DE HIBRIDACION DE POCA RIGUROSIDAD REVELAN LA EXISTENCIA DE GENES RELACIONADOS CON HAP EN EL GENOMA HUMANO. LA SECUENCIA DE DNA CLONADA ES UTIL EN LA PREPARACION DE PROTEINA HAP PURA Y COMO SONDA PARA LA DETECCION Y AISLAMIENTO DE SECUENCIAS COMPLEMENTARIAS DE DNA Y RNA. LA PROTEINA HAP ES UN RECEPTOR DE ACIDO RETINOICO (AR) IDENTIFICADO COMO RAR - BETA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13368787A | 1987-12-16 | 1987-12-16 | |
US07/134,130 US5223606A (en) | 1987-12-16 | 1987-12-17 | Steroid/thyroid hormone receptor-related protein inappropriately expressed in human hepatocellular carcinoma |
US07/209,009 US5149781A (en) | 1987-12-16 | 1988-06-20 | Steroid/thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma |
US27813688A | 1988-11-30 | 1988-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095207T3 true ES2095207T3 (es) | 1997-02-16 |
Family
ID=27495052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88403229T Expired - Lifetime ES2095207T3 (es) | 1987-12-16 | 1988-12-16 | Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn. |
Country Status (8)
Country | Link |
---|---|
US (3) | US6531585B1 (es) |
EP (1) | EP0321362B1 (es) |
AT (1) | ATE143413T1 (es) |
CA (1) | CA1320161C (es) |
DE (1) | DE3855577T2 (es) |
ES (1) | ES2095207T3 (es) |
GR (1) | GR3021954T3 (es) |
WO (1) | WO1989005854A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4035889A (en) * | 1988-06-16 | 1990-01-12 | La Jolla Cancer Research Foundation | Retinoic acid receptor |
US6335159B1 (en) | 1988-06-16 | 2002-01-01 | The Burnham Institute | Retinoic acid receptor ε(rarε) |
US5260432A (en) * | 1989-06-22 | 1993-11-09 | Sloan-Kettering Institute For Cancer Research | Human gamma retinoic acid receptor DNA |
CA2020198A1 (en) * | 1989-06-30 | 1990-12-31 | Pierre Chambon | Human and mouse retinoic acid receptors and genes encoding for them |
FR2658204A1 (fr) * | 1990-02-12 | 1991-08-16 | Inst Nat Sante Rech Med | Nouvelles compositions de cycline a humaine, sequence nucleotidique correspondante, et agents de detection ou de diagnostic de mutations hepatocellulaires induites par le virus hbv. |
US5922596A (en) * | 1990-12-10 | 1999-07-13 | Bristol-Myers Squibb Co. | Promoter of the retinoic acid receptor gene for directing gene expression |
AU2001233114A1 (en) * | 2000-02-04 | 2001-08-14 | Aeomica, Inc. | Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence |
CA3114497A1 (en) | 2013-01-18 | 2014-07-24 | Cornell University | Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4034114A (en) * | 1976-09-15 | 1977-07-05 | Yu Ruey J | Treatment of skin keratoses with retinal |
US4310546A (en) * | 1978-07-31 | 1982-01-12 | Johnson & Johnson | Novel retinoids and their use in preventing carcinogenesis |
US4323581A (en) * | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
US4385175A (en) * | 1982-03-22 | 1983-05-24 | Bristol-Myers Company | Esters of retinoic acid and azetidinone derivatives |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US5571692A (en) * | 1987-12-02 | 1996-11-05 | The Salk Institute For Biological Studies | Retinoic acid receptor α, vectors and cells comprising the same DNA encoding |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
US5171671A (en) * | 1987-12-02 | 1992-12-15 | The Salk Institute For Biological Studies | Retinoic acid receptor composition |
-
1988
- 1988-12-16 CA CA000586206A patent/CA1320161C/en not_active Expired - Lifetime
- 1988-12-16 DE DE3855577T patent/DE3855577T2/de not_active Expired - Lifetime
- 1988-12-16 AT AT88403229T patent/ATE143413T1/de not_active IP Right Cessation
- 1988-12-16 ES ES88403229T patent/ES2095207T3/es not_active Expired - Lifetime
- 1988-12-16 EP EP88403229A patent/EP0321362B1/en not_active Expired - Lifetime
- 1988-12-16 WO PCT/EP1988/001180 patent/WO1989005854A1/en unknown
-
1991
- 1991-02-01 US US07/649,342 patent/US6531585B1/en not_active Expired - Fee Related
-
1996
- 1996-12-10 GR GR960403371T patent/GR3021954T3/el unknown
-
2002
- 2002-12-02 US US10/307,339 patent/US20030153740A1/en not_active Abandoned
-
2006
- 2006-03-21 US US11/384,481 patent/US7622266B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3855577D1 (de) | 1996-10-31 |
DE3855577T2 (de) | 1997-04-17 |
ATE143413T1 (de) | 1996-10-15 |
US6531585B1 (en) | 2003-03-11 |
EP0321362A1 (en) | 1989-06-21 |
EP0321362B1 (en) | 1996-09-25 |
US7622266B2 (en) | 2009-11-24 |
WO1989005854A1 (en) | 1989-06-29 |
US20060189798A1 (en) | 2006-08-24 |
CA1320161C (en) | 1993-07-13 |
GR3021954T3 (en) | 1997-03-31 |
US20030153740A1 (en) | 2003-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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