ES2094531T3 - Aparato y procedimiento de agregacion de particulas. - Google Patents
Aparato y procedimiento de agregacion de particulas.Info
- Publication number
- ES2094531T3 ES2094531T3 ES93905559T ES93905559T ES2094531T3 ES 2094531 T3 ES2094531 T3 ES 2094531T3 ES 93905559 T ES93905559 T ES 93905559T ES 93905559 T ES93905559 T ES 93905559T ES 2094531 T3 ES2094531 T3 ES 2094531T3
- Authority
- ES
- Spain
- Prior art keywords
- tube
- pct
- particles
- standing wave
- date sep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
- B01D21/283—Settling tanks provided with vibrators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
- B01F31/87—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations transmitting the vibratory energy by means of a fluid, e.g. by means of air shock waves
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/34—Treatment of water, waste water, or sewage with mechanical oscillations
- C02F1/36—Treatment of water, waste water, or sewage with mechanical oscillations ultrasonic vibrations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
- G01N33/555—Red blood cell
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Mycology (AREA)
- Water Supply & Treatment (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
UNA MUESTRA (E.G. 52) DE LIQUIDO CON PARTICULAS SUSPENDIDAS ESTA CONTENIDA EN UN TUBO (10) Y SOMETIDA A UN CAMPO DE ONDAS DE ULTRASONIDO TRANSVERSAL AL TUBO (10), EXHIBIENDO LAS ONDAS UN CAMBIO PROGRESIVO EN LA AMPLITUD DE PRESION TRANSVERSAL AL TUBO DE TAL FORMA QUE LAS PARTICULAS EN SUSPENSION SON DESPLAZADAS TRANSVERSALMENTE A UNA O MAS REGIONES PREDETERMINADAS DEL TUBO: LA EXPOSICION DE LA MUESTRA A LAS ONDAS FINALIZA ENTONCES Y SE PERMITE A LAS PARTICULAS SEDIMENTAR Y SE LAS INSPECCIONA PARA DETERMINAR SI PERMANECEN AGREGADAS O ESTAN DISOCIADAS. EL CAMPO DE SONIDO SE PRODUCE POR MEDIO DE UN TRANSDUCTOR (20) DE FORMA TUBULAR QUE RODEA AL TUBO (10). LA INVENCION PUEDE USARSE PARA LA AGLUTINACION DE PARTICULAS O CELULAS VIA MOLECULAS DE CRUCE EN ENSAYOS DE INMUNO-AGLUTINACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9205128A GB2265004B (en) | 1992-03-10 | 1992-03-10 | Immuno-agglutination assay using ultrasonic standing wave field |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094531T3 true ES2094531T3 (es) | 1997-01-16 |
Family
ID=10711782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93905559T Expired - Lifetime ES2094531T3 (es) | 1992-03-10 | 1993-03-10 | Aparato y procedimiento de agregacion de particulas. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5665605A (es) |
EP (1) | EP0630477B1 (es) |
JP (1) | JP3333203B2 (es) |
AT (1) | ATE144837T1 (es) |
AU (1) | AU667708B2 (es) |
CA (1) | CA2130276A1 (es) |
DE (1) | DE69305733T2 (es) |
DK (1) | DK0630477T3 (es) |
ES (1) | ES2094531T3 (es) |
GB (1) | GB2265004B (es) |
GR (1) | GR3022046T3 (es) |
WO (1) | WO1993019367A2 (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2265004B (en) * | 1992-03-10 | 1996-01-10 | Univ Cardiff | Immuno-agglutination assay using ultrasonic standing wave field |
GB2293117A (en) * | 1994-09-13 | 1996-03-20 | Inceltec Ltd | Mixing of chemical reaction components using ultrasound |
US5971586A (en) * | 1995-04-21 | 1999-10-26 | Sony Corporation | Identifying causes of semiconductor production yield loss |
CA2310133A1 (fr) | 1997-11-28 | 1999-06-10 | Compagnie Generale Des Etablissements Michelin - Michelin & Cie | Charge alumineuse renforcante et composition de caoutchouc comportant une telle charge |
GB2339703B (en) * | 1998-07-22 | 2002-05-01 | Univ Cardiff | Particle manipulation device |
GB9905714D0 (en) * | 1999-03-13 | 1999-05-05 | Univ Cardiff | Clarification of plasma from blood samples |
US6086821A (en) * | 1999-03-29 | 2000-07-11 | The United States Of America As Represented By The Secretary Of The Navy | Ultrasonic force differentiation assay |
US6736904B2 (en) | 2001-03-02 | 2004-05-18 | Paper Quality Management Associates | Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid |
JP3828818B2 (ja) * | 2002-03-01 | 2006-10-04 | 株式会社日立ハイテクノロジーズ | 化学分析装置及び化学分析方法 |
JP3892743B2 (ja) * | 2002-03-01 | 2007-03-14 | 日本碍子株式会社 | 反応セルおよびその使用方法 |
US7160516B2 (en) | 2002-07-30 | 2007-01-09 | Sonics & Materials, Inc. | High volume ultrasonic flow cell |
US7108137B2 (en) | 2002-10-02 | 2006-09-19 | Wisconsin Alumni Research Foundation | Method and apparatus for separating particles by size |
GB2426050A (en) * | 2005-05-09 | 2006-11-15 | Orion Diagnostica Oy | Method of measuring binding rate using sonication |
GB0619016D0 (en) * | 2006-09-27 | 2006-11-08 | Secr Defence | Ultrasound method |
US7989177B2 (en) * | 2007-08-20 | 2011-08-02 | Allied Innovative Systems, Llc | Method and device for ultrasound assisted particle agglutination assay |
ES2326109B1 (es) | 2007-12-05 | 2010-06-25 | Consejo Superior De Investigaciones Cientificas | Microdispositivo de separacion y extraccion selectiva y no invasiva de particulas en suspensiones polidispersas, procedimiento de fabricacion y sus aplicaciones. |
WO2009118551A1 (en) * | 2008-03-25 | 2009-10-01 | Prokyma Technologies Limited | Ultrasound method for analysis of blood for blood typing, antibody detection and flow cytometry |
JP2011062607A (ja) * | 2009-09-15 | 2011-03-31 | Chuo Univ | 環状のナノ粒子集合体およびその製造方法 |
US8691145B2 (en) | 2009-11-16 | 2014-04-08 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
US8300303B1 (en) | 2010-01-07 | 2012-10-30 | The United States Of America As Represented By The Secretaryof The Navy | Acoustically focused optical lens |
FR2957532B1 (fr) * | 2010-03-19 | 2012-09-28 | Commissariat Energie Atomique | Agitateur d'un echantillon liquide |
US8956538B2 (en) | 2010-06-16 | 2015-02-17 | Flodesign Sonics, Inc. | Phononic crystal desalination system and methods of use |
US9421553B2 (en) | 2010-08-23 | 2016-08-23 | Flodesign Sonics, Inc. | High-volume fast separation of multi-phase components in fluid suspensions |
US8679338B2 (en) | 2010-08-23 | 2014-03-25 | Flodesign Sonics, Inc. | Combined acoustic micro filtration and phononic crystal membrane particle separation |
EP2701850B1 (en) | 2011-04-27 | 2018-08-15 | Becton Dickinson and Company | Devices and methods for separating magnetically labeled moieties in a sample |
NL1039051C2 (en) * | 2011-09-19 | 2013-03-21 | Stichting Wetsus Ct Excellence Sustainable Water Technology | Filter and filtration method for purifying and/or sampling a liquid. |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
US9272234B2 (en) | 2012-03-15 | 2016-03-01 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US9688958B2 (en) | 2012-03-15 | 2017-06-27 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9567559B2 (en) | 2012-03-15 | 2017-02-14 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9822333B2 (en) | 2012-03-15 | 2017-11-21 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
US9340435B2 (en) | 2012-03-15 | 2016-05-17 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US9416344B2 (en) | 2012-03-15 | 2016-08-16 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
US9623348B2 (en) | 2012-03-15 | 2017-04-18 | Flodesign Sonics, Inc. | Reflector for an acoustophoretic device |
US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US11179747B2 (en) | 2015-07-09 | 2021-11-23 | Flodesign Sonics, Inc. | Non-planar and non-symmetrical piezoelectric crystals and reflectors |
US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9422328B2 (en) | 2012-03-15 | 2016-08-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US10040011B2 (en) | 2012-03-15 | 2018-08-07 | Flodesign Sonics, Inc. | Acoustophoretic multi-component separation technology platform |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
US11324873B2 (en) | 2012-04-20 | 2022-05-10 | Flodesign Sonics, Inc. | Acoustic blood separation processes and devices |
US9170186B2 (en) * | 2012-06-06 | 2015-10-27 | Centre National De La Recherche Scientifique | Method of manipulating objects |
JP2014002050A (ja) * | 2012-06-19 | 2014-01-09 | Hitachi Ltd | 凝集状態検知装置 |
CN104736718A (zh) | 2012-10-26 | 2015-06-24 | 贝克顿·迪金森公司 | 用于操纵流体样品中的组分的装置和方法 |
US9725690B2 (en) | 2013-06-24 | 2017-08-08 | Flodesign Sonics, Inc. | Fluid dynamic sonic separator |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
CN103667051A (zh) * | 2013-12-20 | 2014-03-26 | 河南省医药科学研究院 | 用于肿瘤细胞分离的表面声波微流控芯片 |
CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
CN106470748A (zh) | 2014-05-08 | 2017-03-01 | 弗洛设计声能学公司 | 具有压电换能器阵列的声场装置 |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
US9827511B2 (en) | 2014-07-02 | 2017-11-28 | Flodesign Sonics, Inc. | Acoustophoretic device with uniform fluid flow |
KR20170063882A (ko) | 2014-09-30 | 2017-06-08 | 프로디자인 소닉스, 인크. | 비-유동성 유체 내의 입자의 음향 영동 정화 |
JP2017534446A (ja) | 2014-10-24 | 2017-11-24 | ライフ テクノロジーズ コーポレイション | 音響沈降化液体−液体試料精製システム |
US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
US9670477B2 (en) | 2015-04-29 | 2017-06-06 | Flodesign Sonics, Inc. | Acoustophoretic device for angled wave particle deflection |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
US10640760B2 (en) | 2016-05-03 | 2020-05-05 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
RU2708048C2 (ru) | 2015-05-20 | 2019-12-03 | Флодизайн Соникс, Инк. | Способ акустического манипулирования частицами в полях стоячих волн |
US10161926B2 (en) | 2015-06-11 | 2018-12-25 | Flodesign Sonics, Inc. | Acoustic methods for separation of cells and pathogens |
US9663756B1 (en) | 2016-02-25 | 2017-05-30 | Flodesign Sonics, Inc. | Acoustic separation of cellular supporting materials from cultured cells |
US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
EP3529347A1 (en) | 2016-10-19 | 2019-08-28 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
CA3085784A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB508675A (en) * | 1936-10-24 | 1939-06-26 | Egon Hiedemann | Process for the treatment of liquids containing suspended particles with sound and ultra-sound waves |
US4615984A (en) * | 1984-02-23 | 1986-10-07 | Becton Dickinson & Company | Dissociation of ligand-binder complex using ultrasound |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
FR2607257B1 (fr) * | 1986-11-25 | 1990-04-06 | Rabelais Universite Francois | Procede de traitement biologique par ultrasons, notamment pour tests immuno-hematologiques |
AT389235B (de) * | 1987-05-19 | 1989-11-10 | Stuckart Wolfgang | Verfahren zur reinigung von fluessigkeiten mittels ultraschall und vorrichtungen zur durchfuehrung dieses verfahrens |
GB8905807D0 (en) * | 1989-03-14 | 1989-04-26 | Health Lab Service Board | Particle aggregation |
GB2265004B (en) * | 1992-03-10 | 1996-01-10 | Univ Cardiff | Immuno-agglutination assay using ultrasonic standing wave field |
-
1992
- 1992-03-10 GB GB9205128A patent/GB2265004B/en not_active Expired - Fee Related
-
1993
- 1993-03-10 AT AT93905559T patent/ATE144837T1/de not_active IP Right Cessation
- 1993-03-10 WO PCT/GB1993/000504 patent/WO1993019367A2/en active IP Right Grant
- 1993-03-10 CA CA002130276A patent/CA2130276A1/en not_active Abandoned
- 1993-03-10 JP JP51634593A patent/JP3333203B2/ja not_active Expired - Fee Related
- 1993-03-10 DE DE69305733T patent/DE69305733T2/de not_active Expired - Fee Related
- 1993-03-10 US US08/302,658 patent/US5665605A/en not_active Expired - Fee Related
- 1993-03-10 EP EP93905559A patent/EP0630477B1/en not_active Expired - Lifetime
- 1993-03-10 DK DK93905559.6T patent/DK0630477T3/da active
- 1993-03-10 AU AU36446/93A patent/AU667708B2/en not_active Ceased
- 1993-03-10 ES ES93905559T patent/ES2094531T3/es not_active Expired - Lifetime
-
1996
- 1996-12-16 GR GR960403477T patent/GR3022046T3/el unknown
-
1997
- 1997-09-08 US US08/925,203 patent/US5912182A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH07504985A (ja) | 1995-06-01 |
EP0630477A1 (en) | 1994-12-28 |
DE69305733T2 (de) | 1997-04-30 |
US5912182A (en) | 1999-06-15 |
WO1993019367A2 (en) | 1993-09-30 |
AU3644693A (en) | 1993-10-21 |
US5665605A (en) | 1997-09-09 |
CA2130276A1 (en) | 1993-09-30 |
GR3022046T3 (en) | 1997-03-31 |
JP3333203B2 (ja) | 2002-10-15 |
DK0630477T3 (da) | 1997-04-01 |
EP0630477B1 (en) | 1996-10-30 |
ATE144837T1 (de) | 1996-11-15 |
GB9205128D0 (en) | 1992-04-22 |
DE69305733D1 (de) | 1996-12-05 |
GB2265004B (en) | 1996-01-10 |
AU667708B2 (en) | 1996-04-04 |
GB2265004A (en) | 1993-09-15 |
WO1993019367A3 (en) | 1993-10-28 |
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