ES2094454T3 - Derivado de ketorolac con actividad de irritacion y de ulceracion gastrointestinal reducida. - Google Patents

Derivado de ketorolac con actividad de irritacion y de ulceracion gastrointestinal reducida.

Info

Publication number
ES2094454T3
ES2094454T3 ES93121130T ES93121130T ES2094454T3 ES 2094454 T3 ES2094454 T3 ES 2094454T3 ES 93121130 T ES93121130 T ES 93121130T ES 93121130 T ES93121130 T ES 93121130T ES 2094454 T3 ES2094454 T3 ES 2094454T3
Authority
ES
Spain
Prior art keywords
ketorolac
irritation
derivative
activity
gastrointestinal ulceration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93121130T
Other languages
English (en)
Inventor
Carlos Ernesto Antonio Monti
Gustavo Enrique Aldoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roemmers SAICF
Original Assignee
Roemmers SAICF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roemmers SAICF filed Critical Roemmers SAICF
Application granted granted Critical
Publication of ES2094454T3 publication Critical patent/ES2094454T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA COMBINACION DE LA FORMULA (I), LA CUAL ES EL NUEVO ESTER 2-(1-PIRROLIDINILO)-ETILO DEL ACIDO ORGANICO ( (MAS MENOS) )-5-BENZOILO-2,3-DIHIDRO-1H-PIRROLIZINA-1 O ACIDO KETOROLAC, ASI COMO SUS SALES DE ADICION TOLERABLES FARMACEUTICAMENTE, CON PREFERENCIA EL OXALATO. ES CONOCIDO QUE LA SAL DE TROMETAMOL-KETOROLAC USUAL EN EL COMERCIO, PRESENTA EFECTOS SECUNDARIOS INDESEADOS, EN PARTICULAR, IRRITACION GASTROINTESTINAL Y ULCERACION. ESTOS EFECTOS INDESEADOS SON SORPRENDENTEMENTE TAN PEQUEÑOS CON APLICACION DE LA COMBINACION SEGUN LA INVENCION, QUE ESTA HACE MUY VENTAJOSA POTENCIALMENTE LA SUSTANCIA ACTIVA ANALGESICA/ANTIFLOGISTICA.
ES93121130T 1993-01-13 1993-12-30 Derivado de ketorolac con actividad de irritacion y de ulceracion gastrointestinal reducida. Expired - Lifetime ES2094454T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4300697A DE4300697C1 (de) 1993-01-13 1993-01-13 Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration

Publications (1)

Publication Number Publication Date
ES2094454T3 true ES2094454T3 (es) 1997-01-16

Family

ID=6478109

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93121130T Expired - Lifetime ES2094454T3 (es) 1993-01-13 1993-12-30 Derivado de ketorolac con actividad de irritacion y de ulceracion gastrointestinal reducida.

Country Status (14)

Country Link
US (2) US5508301A (es)
EP (1) EP0606657B1 (es)
JP (1) JPH06316577A (es)
KR (1) KR940018387A (es)
AT (1) ATE144775T1 (es)
CA (1) CA2113226A1 (es)
DE (2) DE4300697C1 (es)
DK (1) DK0606657T3 (es)
ES (1) ES2094454T3 (es)
FI (1) FI105919B (es)
GR (1) GR3021717T3 (es)
HU (1) HU216841B (es)
NO (1) NO301013B1 (es)
ZA (1) ZA94183B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020050188A (ko) * 2002-03-19 2002-06-26 에코바이오젠주식회사 경피흡수제로서의 용도를 위해 지용성이 부가된케토로락의 에스테르 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
ZA882957B (en) * 1987-04-27 1989-12-27 Syntex Pharma Int Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs
DK0519983T3 (da) * 1990-03-16 1996-10-14 Procter & Gamble Anvendelse af ketorolac til behandling af periodontal sygdom

Also Published As

Publication number Publication date
CA2113226A1 (en) 1994-07-14
FI105919B (fi) 2000-10-31
GR3021717T3 (en) 1997-02-28
DK0606657T3 (da) 1997-04-14
DE4300697C1 (de) 1994-05-19
FI940171A (fi) 1994-07-14
NO301013B1 (no) 1997-09-01
HUT70410A (en) 1995-10-30
EP0606657A1 (de) 1994-07-20
DE59304359D1 (de) 1996-12-05
HU9400006D0 (en) 1994-05-30
KR940018387A (ko) 1994-08-16
US5508301A (en) 1996-04-16
ATE144775T1 (de) 1996-11-15
US5574170A (en) 1996-11-12
HU216841B (hu) 1999-09-28
NO940109D0 (no) 1994-01-12
JPH06316577A (ja) 1994-11-15
NO940109L (no) 1994-07-14
ZA94183B (en) 1994-08-18
EP0606657B1 (de) 1996-10-30
FI940171A0 (fi) 1994-01-13

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