NO940109D0 - Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjon - Google Patents
Ketorolac-derivater med betydelig redusert gastrointestinal irrit asjon og ulcerasjonInfo
- Publication number
- NO940109D0 NO940109D0 NO940109A NO940109A NO940109D0 NO 940109 D0 NO940109 D0 NO 940109D0 NO 940109 A NO940109 A NO 940109A NO 940109 A NO940109 A NO 940109A NO 940109 D0 NO940109 D0 NO 940109D0
- Authority
- NO
- Norway
- Prior art keywords
- ulceration
- ketorolac
- significantly reduced
- gastrointestinal irritation
- reduced gastrointestinal
- Prior art date
Links
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 title abstract 2
- 208000025865 Ulcer Diseases 0.000 title abstract 2
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical class OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 title abstract 2
- 230000036269 ulceration Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 229960004752 ketorolac Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 trometamole salt Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4300697A DE4300697C1 (de) | 1993-01-13 | 1993-01-13 | Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO940109D0 true NO940109D0 (no) | 1994-01-12 |
| NO940109L NO940109L (no) | 1994-07-14 |
| NO301013B1 NO301013B1 (no) | 1997-09-01 |
Family
ID=6478109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO940109A NO301013B1 (no) | 1993-01-13 | 1994-01-12 | Ketorolac-derivater med betydelig redusert gastrointestinal irritasjon og ulcerasjon |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5508301A (no) |
| EP (1) | EP0606657B1 (no) |
| JP (1) | JPH06316577A (no) |
| KR (1) | KR940018387A (no) |
| AT (1) | ATE144775T1 (no) |
| CA (1) | CA2113226A1 (no) |
| DE (2) | DE4300697C1 (no) |
| DK (1) | DK0606657T3 (no) |
| ES (1) | ES2094454T3 (no) |
| FI (1) | FI105919B (no) |
| GR (1) | GR3021717T3 (no) |
| HU (1) | HU216841B (no) |
| NO (1) | NO301013B1 (no) |
| ZA (1) | ZA94183B (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020050188A (ko) * | 2002-03-19 | 2002-06-26 | 에코바이오젠주식회사 | 경피흡수제로서의 용도를 위해 지용성이 부가된케토로락의 에스테르 유도체 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
| AU1508988A (en) * | 1987-04-27 | 1988-10-27 | Syntex Pharmaceuticals International Ltd. | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
| AU661818B2 (en) * | 1990-03-16 | 1995-08-10 | Procter & Gamble Company, The | Use of ketorolac for treatment of periodontal disease |
-
1993
- 1993-01-13 DE DE4300697A patent/DE4300697C1/de not_active Expired - Fee Related
- 1993-12-30 EP EP93121130A patent/EP0606657B1/de not_active Expired - Lifetime
- 1993-12-30 AT AT93121130T patent/ATE144775T1/de active
- 1993-12-30 ES ES93121130T patent/ES2094454T3/es not_active Expired - Lifetime
- 1993-12-30 DK DK93121130.4T patent/DK0606657T3/da active
- 1993-12-30 DE DE59304359T patent/DE59304359D1/de not_active Expired - Fee Related
-
1994
- 1994-01-03 HU HU9400006A patent/HU216841B/hu not_active IP Right Cessation
- 1994-01-07 US US08/178,541 patent/US5508301A/en not_active Expired - Fee Related
- 1994-01-11 CA CA002113226A patent/CA2113226A1/en not_active Abandoned
- 1994-01-12 KR KR1019940000417A patent/KR940018387A/ko not_active Application Discontinuation
- 1994-01-12 ZA ZA94183A patent/ZA94183B/xx unknown
- 1994-01-12 NO NO940109A patent/NO301013B1/no unknown
- 1994-01-12 JP JP6013935A patent/JPH06316577A/ja active Pending
- 1994-01-13 FI FI940171A patent/FI105919B/fi active
-
1995
- 1995-06-06 US US08/468,648 patent/US5574170A/en not_active Expired - Fee Related
-
1996
- 1996-11-20 GR GR960403112T patent/GR3021717T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT70410A (en) | 1995-10-30 |
| NO940109L (no) | 1994-07-14 |
| EP0606657A1 (de) | 1994-07-20 |
| DK0606657T3 (da) | 1997-04-14 |
| JPH06316577A (ja) | 1994-11-15 |
| US5574170A (en) | 1996-11-12 |
| FI940171A0 (fi) | 1994-01-13 |
| CA2113226A1 (en) | 1994-07-14 |
| US5508301A (en) | 1996-04-16 |
| DE59304359D1 (de) | 1996-12-05 |
| NO301013B1 (no) | 1997-09-01 |
| ES2094454T3 (es) | 1997-01-16 |
| ATE144775T1 (de) | 1996-11-15 |
| HU9400006D0 (en) | 1994-05-30 |
| GR3021717T3 (en) | 1997-02-28 |
| ZA94183B (en) | 1994-08-18 |
| KR940018387A (ko) | 1994-08-16 |
| FI940171A (fi) | 1994-07-14 |
| HU216841B (hu) | 1999-09-28 |
| DE4300697C1 (de) | 1994-05-19 |
| FI105919B (fi) | 2000-10-31 |
| EP0606657B1 (de) | 1996-10-30 |
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