ES2089761T3 - Nuevos derivados de p-(di-(2-cloro-etil)-amino)-fenil-alanina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de p-(di-(2-cloro-etil)-amino)-fenil-alanina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2089761T3
ES2089761T3 ES93403109T ES93403109T ES2089761T3 ES 2089761 T3 ES2089761 T3 ES 2089761T3 ES 93403109 T ES93403109 T ES 93403109T ES 93403109 T ES93403109 T ES 93403109T ES 2089761 T3 ES2089761 T3 ES 2089761T3
Authority
ES
Spain
Prior art keywords
ethl
alanine
chlorine
phenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93403109T
Other languages
English (en)
Inventor
Alex Cordi
Angela D Morris
Ghanem Atassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2089761T3 publication Critical patent/ES2089761T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTO DE FORMULA (I): EN EL QUE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALCOXICARBONILO (C1 RAMIFICADO, O FENILALCOXICARBONILO SUSTITUIDO O NO SUSTITUIDO; R2 REPRESENTA UNO CUALQUIERA DE LOS AGRUPAMIENTOS SIGUIENTES:, EN LOS CUALES R3 O R4, IDENTICOS O DIFERENTES, REPRESENTAN UN RADICAL ALQUILO (C6
ES93403109T 1992-12-21 1993-12-21 Nuevos derivados de p-(di-(2-cloro-etil)-amino)-fenil-alanina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2089761T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9215319A FR2699536B1 (fr) 1992-12-21 1992-12-21 Nouveaux dérivés de p-[di(2-chloroéthyl)amino]phénylalanine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2089761T3 true ES2089761T3 (es) 1996-10-01

Family

ID=9436794

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93403109T Expired - Lifetime ES2089761T3 (es) 1992-12-21 1993-12-21 Nuevos derivados de p-(di-(2-cloro-etil)-amino)-fenil-alanina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (13)

Country Link
US (1) US5424464A (es)
EP (1) EP0604301B1 (es)
JP (1) JPH06247914A (es)
AT (1) ATE138641T1 (es)
AU (1) AU661622B2 (es)
CA (1) CA2111875A1 (es)
DE (1) DE69302889T2 (es)
DK (1) DK0604301T3 (es)
ES (1) ES2089761T3 (es)
FR (1) FR2699536B1 (es)
GR (1) GR3020323T3 (es)
NZ (1) NZ250512A (es)
ZA (1) ZA939576B (es)

Also Published As

Publication number Publication date
CA2111875A1 (fr) 1994-06-22
ATE138641T1 (de) 1996-06-15
AU661622B2 (en) 1995-07-27
DK0604301T3 (da) 1996-10-14
NZ250512A (en) 1995-03-28
GR3020323T3 (en) 1996-09-30
DE69302889T2 (de) 1996-11-28
DE69302889D1 (de) 1996-07-04
JPH06247914A (ja) 1994-09-06
FR2699536B1 (fr) 1995-03-03
EP0604301A1 (fr) 1994-06-29
US5424464A (en) 1995-06-13
EP0604301B1 (fr) 1996-05-29
AU5251093A (en) 1994-06-30
ZA939576B (en) 1994-08-11
FR2699536A1 (fr) 1994-06-24

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