ES2087560T3 - Nuevos compuestos pentaciclicos y su utilizacion como colorantes de absorcion o de fluorescencia. - Google Patents

Nuevos compuestos pentaciclicos y su utilizacion como colorantes de absorcion o de fluorescencia.

Info

Publication number
ES2087560T3
ES2087560T3 ES92923736T ES92923736T ES2087560T3 ES 2087560 T3 ES2087560 T3 ES 2087560T3 ES 92923736 T ES92923736 T ES 92923736T ES 92923736 T ES92923736 T ES 92923736T ES 2087560 T3 ES2087560 T3 ES 2087560T3
Authority
ES
Spain
Prior art keywords
carbon atoms
group
alkyl
halogen
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92923736T
Other languages
English (en)
Inventor
Rupert Herrmann
Hans-Peter Josel
Karl-Heinz Drexhage
Jutta Arden-Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2087560T3 publication Critical patent/ES2087560T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Optical Filters (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBEN DERIVADOS PENTACICLICOS DE FORMULAS (IA, IB, IC), ASI COMO POR LO MENOS SUS DERIVADOS QUE SE ACTIVAN EN UNO DE LOS RESTOS R1, R7 Y/O R13. LOS COMPUESTOS SE UTILIZAN COMO COLORANTES DE ABSORCION O DE FLUORESCENCIA PARTICULARMENTE COMO MARCADORES PARA EL CONJUGADO DE PROTEINA/ANTICUERPO/HAPTENO, Y COMO COLORANTE LASER O COMO MEDIO DE ABSORCION PARA COLECTORES SOLARES. SIENDO: R1 Y R13 IGUALES O DIFERENTES HIDROGENO, ALQUILO DE C 1 A 20, POLIOXIHIDROCARBILO, FENILO FENILOALQUILO DE C 1 A 3; R7 UN GRUPO ALQUILO DE C 1 A 7 SUSTITUIDO POR UN HALOGENO, UN GRUPO CARBOXILOALQUILO O FENILO QUE ES SUSTITUIDO POR UN HALOGENO O POR UN GRUPO CARBOXI U ALCOXICARBONILO LOCALIZADO EN EL CARBONO SITUADO EN POSICION ORTO DEL SISTEMA ANULAR PENTACICLICO O UN GRUPO CARBOXIMETILENO-ALQUILOXI; R14 Y R15, LAS POSICIONES DEL ANILLO NO ESPECIFICAS Y LOS SUSTITUYENTES PUENTEABLES SON ENLACES EN LINEAS DE TROZOS, YA QUE AMBOS ATOMOS DE CARBONO UNIDOS A TRAVES DE ENLACES POR LINEAS DE TROZOS PUEDEN SER UNIDOS POR ENLACES DOBLES Y SENCILLOS Y X UN CONTRAION. LOS RESTOS R1 Y R13 ALQUILO Y FENILO PUEDEN ESTAR SUSTITUIDOS A TRAVES DE UNO O VARIOS GRUPOS HIDROXI, HALOGENO, SULFO, CARBOXI O ALCOSI CARBONILO, TENIENDO EL RESTO ALCOXI DE C 1 A 4.
ES92923736T 1991-11-18 1992-11-17 Nuevos compuestos pentaciclicos y su utilizacion como colorantes de absorcion o de fluorescencia. Expired - Lifetime ES2087560T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4137934A DE4137934A1 (de) 1991-11-18 1991-11-18 Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe

Publications (1)

Publication Number Publication Date
ES2087560T3 true ES2087560T3 (es) 1996-07-16

Family

ID=6445073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92923736T Expired - Lifetime ES2087560T3 (es) 1991-11-18 1992-11-17 Nuevos compuestos pentaciclicos y su utilizacion como colorantes de absorcion o de fluorescencia.

Country Status (7)

Country Link
EP (2) EP0543333A1 (es)
JP (3) JP2634950B2 (es)
AT (1) ATE137253T1 (es)
DE (2) DE4137934A1 (es)
DK (1) DK0567622T3 (es)
ES (1) ES2087560T3 (es)
WO (1) WO1993010189A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792389A (en) * 1993-10-27 1998-08-11 United States Of America Water soluble laser dyes
DE19521231A1 (de) * 1995-06-10 1996-12-12 Boehringer Mannheim Gmbh Neue Oxazinfarbstoffe und ihre Verwendung als Fluoreszenzmarker
DE19780856D2 (de) 1996-08-16 1999-09-23 Roche Diagnostics Gmbh Kontrollsystem für die Überwachung der regelmäßigen Einnahme eines Medikamentes
US6130101A (en) * 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US5936087A (en) * 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
EP0934986A1 (de) * 1997-12-17 1999-08-11 Roche Diagnostics GmbH Farbstoff-Polyaccharid- bzw. Cyclosaccharid-Konjugate und deren Verwendung als Diagnostikum
DE19824535A1 (de) * 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
DE19919120A1 (de) 1999-04-27 2000-11-02 Drexhage Karl Heinz Neue Amidopyrylium-Fluoreszenz-Farbstoffe
DE19919119A1 (de) * 1999-04-27 2000-11-02 Drexhage Karl Heinz Neue Carbopyronin-Fluoreszenz-Farbstoffe
DE19923168A1 (de) * 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
AU2002221848A1 (en) 2000-11-16 2002-05-27 Belik, Daniel Dye pair for fluorescence resonance energy transfer (fret) measurements
ES2269614T3 (es) 2001-08-31 2007-04-01 The University Of Utah Research Foundation Cuantificacion de genes en tiempo real con estandares internos.
AU2003233980A1 (en) * 2002-05-17 2003-12-02 Ciba Speciality Chemicals Holding Inc. High-performance optical storage media
DE10329860A1 (de) 2003-07-02 2005-01-20 Atto-Tec Gmbh Sulfonamidderivate polycyclischer Farbstoffe für analytische Anwendungen
EP1632578A1 (en) 2004-09-03 2006-03-08 Roche Diagnostics GmbH DNA decontamination method
DE102004045748A1 (de) * 2004-09-21 2006-04-06 Roche Diagnostics Gmbh Stöchiometrisch definierte farbstoffmarkierte Substanzen zur Messung der glomerulären Filtrationsrate, ihre Herstellung und Verwendung
JP5707162B2 (ja) * 2011-02-10 2015-04-22 富士フイルム株式会社 硬化性着色組成物、カラーフィルタ及びその製造方法、液晶表示装置、固体撮像素子、並びに、色素化合物
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
US20230050863A1 (en) 2019-12-09 2023-02-16 Roche Molecular Systems, Inc. Dicationic fluorescent dyes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3322945A1 (de) * 1983-06-25 1985-01-03 Bayer Ag, 5090 Leverkusen Laserfarbstoffe
US4900686A (en) * 1987-04-02 1990-02-13 Polaroid Corporation Fluorescent conjugates and biological diagnostic assay
US4933471A (en) * 1988-08-31 1990-06-12 Becton, Dickinson And Company Xanthene dyes

Also Published As

Publication number Publication date
DE59206119D1 (de) 1996-05-30
JP3448151B2 (ja) 2003-09-16
JP3383736B2 (ja) 2003-03-04
EP0567622A1 (de) 1993-11-03
ATE137253T1 (de) 1996-05-15
JPH0977982A (ja) 1997-03-25
JP2634950B2 (ja) 1997-07-30
JPH05509131A (ja) 1993-12-16
EP0567622B1 (de) 1996-04-24
EP0543333A1 (de) 1993-05-26
DK0567622T3 (da) 1996-08-12
DE4137934A1 (de) 1993-05-19
JPH0967523A (ja) 1997-03-11
WO1993010189A1 (de) 1993-05-27

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