ES2085576T3 - Lactamas n-bifenilil sustituidas. - Google Patents
Lactamas n-bifenilil sustituidas.Info
- Publication number
- ES2085576T3 ES2085576T3 ES92310353T ES92310353T ES2085576T3 ES 2085576 T3 ES2085576 T3 ES 2085576T3 ES 92310353 T ES92310353 T ES 92310353T ES 92310353 T ES92310353 T ES 92310353T ES 2085576 T3 ES2085576 T3 ES 2085576T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- angiotensin
- mammal
- compound
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
- C07D209/74—4,7-Endo-alkylene-iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EL INVENTO SE REFIERE A NUEVOS COMPUESTOS DE LACTAMA DE NFENILILO CON UNA MITAD DE METILO O METILIDENO SUSTITUIDA ADYACENTE AL NITROGENO DE LACTAMA, Y SALES FARMACEUTICAMENTE ACEPTABLES CONSIGUIENTES. LOS COMPUESTOS SON ANTAGONISTAS DE RECEPTOR DE ANGIOTENSINA II, Y SON UTILES EN EL TRATAMIENTO DE HIPERTENSION (AL REBAJAR LA PRESION SANGUINEA ALTA), INSUFICIENCIA CARDIACA CONGESTIVA, PRESION OCULAR ELEVADA, ATAQUE CEREBRAL, ANGINA, INSUFICIENCIA CARDIACA, INFARTO DE MIOCARDIO O NEFROPATIA DIABETICA. EL INVENTO SE REFIERE ASIMISMO A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO DEL INVENTO, UN METODO DE TRATAMIENTO DE UNA CONDICION FISIOLOGICA EN UN MAMIFERO CON MEDIACION DE ANGIOTENSINA II QUE COMPRENDE ADMINISTRAR AL MAMIFERO UNA CANTIDAD EFICAZ DEL COMPUESTO DEL INVENTO, Y NUEVOS PROCESOS PARA PREPARAR LOS COMPUESTOS DEL INVENTO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/791,939 US5182288A (en) | 1991-11-13 | 1991-11-13 | Substituted n-biphenylyl lactams |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085576T3 true ES2085576T3 (es) | 1996-06-01 |
Family
ID=25155294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92310353T Expired - Lifetime ES2085576T3 (es) | 1991-11-13 | 1992-11-12 | Lactamas n-bifenilil sustituidas. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5182288A (es) |
EP (1) | EP0542554B1 (es) |
JP (1) | JP3257709B2 (es) |
AT (1) | ATE133664T1 (es) |
AU (1) | AU651017B2 (es) |
CA (1) | CA2082787A1 (es) |
DE (1) | DE69208036T2 (es) |
DK (1) | DK0542554T3 (es) |
ES (1) | ES2085576T3 (es) |
GR (1) | GR3019118T3 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1622569T3 (pl) | 2003-04-24 | 2016-06-30 | Incyte Holdings Corp | Pochodne aza spiro alkanów jako inhibitory metaloproteaz |
AU2004265300A1 (en) | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Sulfonyl substituted N-(biarylmethyl) aminocyclopropanecarboxamides |
EP1749828A1 (en) | 2005-08-04 | 2007-02-07 | Farmaprojects S.L. | Process for preparing an angiotensin II receptor antagonist |
US7910108B2 (en) * | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3140285A (en) * | 1960-09-12 | 1964-07-07 | Sterling Drug Inc | Maleimide adducts of alpha-phellandrene and new products therefrom |
DE69024556T2 (de) * | 1989-07-28 | 1996-10-17 | Merck & Co Inc | Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten |
EP0442473B1 (en) * | 1990-02-15 | 1998-08-19 | Takeda Chemical Industries, Ltd. | Pyrimidinedione derivatives, their production and use |
IE910913A1 (en) * | 1990-03-20 | 1991-09-25 | Sanofi Sa | N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them |
IL99372A0 (en) * | 1990-09-10 | 1992-08-18 | Ciba Geigy Ag | Azacyclic compounds |
-
1991
- 1991-11-13 US US07/791,939 patent/US5182288A/en not_active Expired - Lifetime
-
1992
- 1992-11-11 AU AU28300/92A patent/AU651017B2/en not_active Ceased
- 1992-11-12 AT AT92310353T patent/ATE133664T1/de not_active IP Right Cessation
- 1992-11-12 CA CA002082787A patent/CA2082787A1/en not_active Abandoned
- 1992-11-12 EP EP92310353A patent/EP0542554B1/en not_active Expired - Lifetime
- 1992-11-12 DK DK92310353.5T patent/DK0542554T3/da active
- 1992-11-12 DE DE69208036T patent/DE69208036T2/de not_active Expired - Fee Related
- 1992-11-12 ES ES92310353T patent/ES2085576T3/es not_active Expired - Lifetime
- 1992-11-13 JP JP32880992A patent/JP3257709B2/ja not_active Expired - Fee Related
-
1993
- 1993-01-21 US US08/006,591 patent/US5246940A/en not_active Expired - Lifetime
-
1996
- 1996-02-28 GR GR960400542T patent/GR3019118T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2082787A1 (en) | 1993-05-14 |
EP0542554A1 (en) | 1993-05-19 |
EP0542554B1 (en) | 1996-01-31 |
AU2830092A (en) | 1993-05-20 |
ATE133664T1 (de) | 1996-02-15 |
DK0542554T3 (da) | 1996-02-19 |
US5182288A (en) | 1993-01-26 |
JPH05262722A (ja) | 1993-10-12 |
JP3257709B2 (ja) | 2002-02-18 |
DE69208036T2 (de) | 1996-07-11 |
US5246940A (en) | 1993-09-21 |
GR3019118T3 (en) | 1996-05-31 |
DE69208036D1 (de) | 1996-03-14 |
AU651017B2 (en) | 1994-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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