ES2085199B1 - Un procedimiento para la preparacion de una formulacion depot. - Google Patents
Un procedimiento para la preparacion de una formulacion depot.Info
- Publication number
- ES2085199B1 ES2085199B1 ES09250039A ES9250039A ES2085199B1 ES 2085199 B1 ES2085199 B1 ES 2085199B1 ES 09250039 A ES09250039 A ES 09250039A ES 9250039 A ES9250039 A ES 9250039A ES 2085199 B1 ES2085199 B1 ES 2085199B1
- Authority
- ES
- Spain
- Prior art keywords
- depot formulation
- procedure
- preparation
- growth factor
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 239000011230 binding agent Substances 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE UNA FORMULACION DEPOT. EL PROCEDIMIENTO COMPRENDE (A) ENLAZAR UN AGENTE QUE SE UNE A FACTOR DE CRECIMIENTO, A FIBRONECTINA O A UN FRAGMENTO DE ELLA; (B) PERMITIR AL MATERIAL QUE CAPTURE UN FACTOR DE CRECIMIENTO. LA FORMULACION DEPOT ES UTIL PARA EL TRATAMIENTO DE HERIDAS EN SERES HUMANOS Y ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919101183A GB9101183D0 (en) | 1991-01-18 | 1991-01-18 | Depot formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2085199A1 ES2085199A1 (es) | 1996-05-16 |
ES2085199B1 true ES2085199B1 (es) | 1996-12-01 |
Family
ID=10688700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09250039A Expired - Fee Related ES2085199B1 (es) | 1991-01-18 | 1992-01-17 | Un procedimiento para la preparacion de una formulacion depot. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0567528B1 (es) |
JP (1) | JPH06504546A (es) |
AT (1) | ATE191855T1 (es) |
AU (1) | AU660447B2 (es) |
CH (1) | CH684783A5 (es) |
DE (1) | DE69230932T2 (es) |
ES (1) | ES2085199B1 (es) |
GB (1) | GB9101183D0 (es) |
WO (1) | WO1992012739A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9101191D0 (en) * | 1991-01-18 | 1991-02-27 | Univ London | Wound treatment |
US6274134B1 (en) | 1992-01-29 | 2001-08-14 | National Institutes Of Health | Human cell adhesion protein AAMP-1 and uses thereof |
AU2823495A (en) * | 1994-06-09 | 1996-01-04 | Houston Biotechnology Incorporated | Methods and compositions for modulation of wound healing |
US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
DE19813663A1 (de) * | 1998-03-27 | 1999-10-07 | Beiersdorf Ag | Wundauflagen zur Entfernung von Störfaktoren aus Wundflüssigkeit |
GB9826658D0 (en) * | 1998-12-03 | 1999-01-27 | Univ London | Tissue repair |
MXPA01010567A (es) * | 1999-04-22 | 2005-04-29 | Eth Zurich And University Of Z | Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2044856T3 (es) * | 1986-04-04 | 1994-01-16 | Allergan Inc | Composicion de mortero para emplear heridas corneales. |
GB8628398D0 (en) * | 1986-11-27 | 1986-12-31 | Central Blood Lab Authority | Pharmaceutically-active conjugates |
NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
KR890701070A (ko) * | 1987-11-09 | 1989-12-19 | 원본미기재 | 보철 장치의 이식방법 |
WO1989004172A1 (en) * | 1987-11-09 | 1989-05-18 | Chiron Ophthalmics Inc. | Wound healing composition and method |
US4973466A (en) * | 1988-06-21 | 1990-11-27 | Chiron Ophthalmics, Inc. | Wound-healing dressings and methods |
KR910700063A (ko) * | 1988-12-20 | 1991-03-13 | 알. 더글라스 암스트롱 | 상처 치료 활성을 갖는 폴리펩티드-고분자 결합체 |
DE3926558A1 (de) * | 1989-01-12 | 1990-07-26 | Orenstein & Koppel Ag | Einrichtung zur ueberwachung von foerderbaendern |
-
1991
- 1991-01-18 GB GB919101183A patent/GB9101183D0/en active Pending
-
1992
- 1992-01-17 EP EP92903396A patent/EP0567528B1/en not_active Expired - Lifetime
- 1992-01-17 WO PCT/GB1992/000101 patent/WO1992012739A1/en not_active IP Right Cessation
- 1992-01-17 AT AT92903396T patent/ATE191855T1/de not_active IP Right Cessation
- 1992-01-17 CH CH2982/92A patent/CH684783A5/de not_active IP Right Cessation
- 1992-01-17 DE DE69230932T patent/DE69230932T2/de not_active Expired - Fee Related
- 1992-01-17 ES ES09250039A patent/ES2085199B1/es not_active Expired - Fee Related
- 1992-01-17 JP JP4503560A patent/JPH06504546A/ja active Pending
- 1992-01-17 AU AU11666/92A patent/AU660447B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1992012739A1 (en) | 1992-08-06 |
ATE191855T1 (de) | 2000-05-15 |
AU1166692A (en) | 1992-08-27 |
EP0567528A1 (en) | 1993-11-03 |
DE69230932D1 (de) | 2000-05-25 |
EP0567528B1 (en) | 2000-04-19 |
DE69230932T2 (de) | 2000-12-14 |
GB9101183D0 (en) | 1991-02-27 |
CH684783A5 (de) | 1994-12-30 |
JPH06504546A (ja) | 1994-05-26 |
AU660447B2 (en) | 1995-06-29 |
ES2085199A1 (es) | 1996-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA2A | Application withdrawn |
Effective date: 19940505 |
|
EC2A | Search report published |
Date of ref document: 19920117 Kind code of ref document: B1 Effective date: 19920117 |
|
FD1A | Patent lapsed |
Effective date: 20060118 |