ES2084061T3 - Composicion y procedimiento de ensayo de cuerpos cetonicos. - Google Patents

Composicion y procedimiento de ensayo de cuerpos cetonicos.

Info

Publication number
ES2084061T3
ES2084061T3 ES91109858T ES91109858T ES2084061T3 ES 2084061 T3 ES2084061 T3 ES 2084061T3 ES 91109858 T ES91109858 T ES 91109858T ES 91109858 T ES91109858 T ES 91109858T ES 2084061 T3 ES2084061 T3 ES 2084061T3
Authority
ES
Spain
Prior art keywords
composition
beta
hydroxybutyrate
reagent
ketone bodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91109858T
Other languages
English (en)
Inventor
Thomas A Magers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2084061T3 publication Critical patent/ES2084061T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

SE PRESENTA UNA COMPOSICION, UN DISPOSITIVO DE PRUEBA Y UN METODO PARA DETERMINAR LA PRESENCIA O CONCENTRACION DE CUERPOS DE CETONA, Y ESPECIFICAMENTE D-BETA-HIDROXIBUTIRATO, EN UNA MUESTRA DE PRUEBA. EL DISPOSITIVO DE PRUEBA INCLUYE UNA ALMOHADILLA DE PRUEBA QUE CONTIENE UNA MATRIZ DE UN PORTADOR ADECUADO QUE INCORPORA UNA COMPOSICION REACTIVA INDICADORA CAPAZ DE INTERACTUAR CON D-BETA-HIDROXIBUTIRATO PARA PRODUCIR UNA RESPUESTA DETECTABLE O MEDIBLE. ADEMAS, SE INCORPORA UNA COMPOSICION REACTIVA INDICADORA NUEVA Y MEJORADA, QUE CONTIENE A) UN COLORANTE INDICADOR QUE ES SENSIBLE A TIOLES, COMO UN ISOBENZOTIAZOLONE SUSTITUIDO, REACTIVO DE ELLMAN O UN DERIVADO DE REACTIVO DE ELLMAN; B) DEHIDROGENASA DE D-BETA-HIDROXIBUTIRATO; C) DEHIDROGENASA DE LIPOAMIDA; D) D, L-LIPOAMIDA; Y E) DINUCLEOTIDO DE ADENINA NICOTINAMIDA, EN LA MATRIZ PORTADORA PARA PROPORCIONAR UNA PRUEBA PRECISA Y SENSIBLE DE UNA MUESTRA DE PRUEBA PARA D-BETA-HIDROXIBUTIRATO (DHBA) EN ESPECIAL, Y PARA CUERPOS DE CETONA EN GENERAL. EL METODO Y LA COMPOSICION MEJORADOS SON ESPECIALMENTE UTILES EN LAS PRUEBAS DE SANGRE COMPLETA, SUERO SANGUINEO, PLASMA SANGUINEO Y ORINA PARA CUERPOS DE CETONA.
ES91109858T 1990-06-29 1991-06-15 Composicion y procedimiento de ensayo de cuerpos cetonicos. Expired - Lifetime ES2084061T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/545,634 US5190863A (en) 1990-06-29 1990-06-29 Composition for determining the presence or concentration of D-β-hydroxybutyrate

Publications (1)

Publication Number Publication Date
ES2084061T3 true ES2084061T3 (es) 1996-05-01

Family

ID=24176972

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91109858T Expired - Lifetime ES2084061T3 (es) 1990-06-29 1991-06-15 Composicion y procedimiento de ensayo de cuerpos cetonicos.

Country Status (9)

Country Link
US (2) US5190863A (es)
EP (1) EP0463524B1 (es)
JP (1) JP3118029B2 (es)
AT (1) ATE135052T1 (es)
AU (1) AU628751B2 (es)
CA (1) CA2042645A1 (es)
DE (1) DE69117588T2 (es)
DK (1) DK0463524T3 (es)
ES (1) ES2084061T3 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190863A (en) * 1990-06-29 1993-03-02 Miles Inc. Composition for determining the presence or concentration of D-β-hydroxybutyrate
US5633143A (en) * 1991-12-12 1997-05-27 Asahi Kasei Kogyo Kabushiki Kaisha Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor
US5510245A (en) * 1992-09-08 1996-04-23 Bayer Corporation Composition and method of assaying for ketone bodies
US5516700A (en) * 1993-05-28 1996-05-14 Chimera Research And Chemical, Inc. Automated urinalysis method
US6541216B1 (en) 1999-12-22 2003-04-01 Roche Diagnostics Corporation Amperometric biosensor test strip
US6583722B2 (en) 2000-12-12 2003-06-24 Kimberly-Clark Worldwide, Inc. Wetness signaling device
US6603403B2 (en) 2000-12-12 2003-08-05 Kimberly-Clark Worldwide, Inc. Remote, wetness signaling system
US6762035B1 (en) * 2002-02-04 2004-07-13 Surendra K. Gupta Method and test strips for the measurement of fat loss during weight loss programs
US6703216B2 (en) 2002-03-14 2004-03-09 The Regents Of The University Of California Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
US7723118B2 (en) * 2002-10-18 2010-05-25 Alt Bioscience, Llc. Compositions and methods for simultaneous detection of volatile sulfur compounds and polyamines
MX2008007517A (es) * 2005-12-15 2009-03-04 Nestec Sa Composiciones y metodos para preservar la funcion cerebral.
BRPI0806877A2 (pt) 2007-01-23 2014-04-29 Bayer Healthcare Llc Dispositivo de teste de analito
ATE523479T1 (de) * 2007-08-25 2011-09-15 Exxonmobil Chem Patents Inc Verfahren zur herstellung von cyclohexylbenzen
KR101151978B1 (ko) * 2007-09-21 2012-06-01 엑손모빌 케미칼 패턴츠 인코포레이티드 사이클로헥실벤젠의 제조방법
KR101175849B1 (ko) * 2007-09-21 2012-08-24 엑손모빌 케미칼 패턴츠 인코포레이티드 사이클로헥실벤젠의 제조방법
ES2392015T3 (es) * 2008-02-12 2012-12-03 Exxonmobil Chemical Patents Inc. Procedimiento para producir ciclohexilbenceno
EP2297071B1 (en) 2008-04-14 2016-03-30 ExxonMobil Chemical Patents Inc. Process for producing cyclohexylbenzene
US20090305317A1 (en) * 2008-06-05 2009-12-10 Brauer Jacob S User interface for testing device
WO2010014402A1 (en) * 2008-07-28 2010-02-04 Exxonmobil Chemical Patents Inc. Hydroalkylation of aromatic compounds using emm-12
WO2010098798A2 (en) 2009-02-26 2010-09-02 Exxonmobil Chemical Patents Inc. Process for producing cyclohexylbenzene
US8500990B2 (en) * 2009-04-22 2013-08-06 Nova Biomedical Corporation Electrochemical biosensors based on NAD(P)-dependent dehydrogenase enzymes
US8633343B2 (en) 2009-05-26 2014-01-21 Exxonmobil Chemical Patents Inc. Transalkylation of polycyclohexylbenzenes
US10392646B2 (en) 2012-10-17 2019-08-27 University Of Maryland, College Park Device and methods of using device for detection of aminoacidopathies
EP3132049B1 (en) * 2014-04-17 2021-08-25 University of Maryland, College Park Device and methods of using device for detection of aminoacidopathies
WO2016176366A1 (en) 2015-04-27 2016-11-03 University Of Maryland, College Park Device and methods of using device for detection of hyperammonemia
AU2019336336A1 (en) * 2018-09-06 2021-03-25 AusMed Global Limited Systems, sensors and methods for determining a concentration of an analyte
CN115996769A (zh) 2020-06-01 2023-04-21 甘布罗伦迪亚股份公司 用于体外血液处理的系统和方法
CN116018084A (zh) * 2020-09-18 2023-04-25 美敦力迷你迈德公司 酮体感测装置和方法
CN114965641B (zh) * 2022-05-23 2024-05-28 可孚医疗科技股份有限公司 一种β-羟丁酸电化学试纸、制备方法及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147514A (en) * 1977-11-21 1979-04-03 Miles Laboratories, Inc. Test means and method for detecting ketone bodies
US4254222A (en) * 1978-07-19 1981-03-03 Owen Oliver E Semi-quantitative assay of lactic acid and β-hydroxy butyrate
US4351899A (en) * 1978-07-19 1982-09-28 Owen Oliver E Semi-quantitative assay of metabolic acids
US4288541A (en) * 1979-10-15 1981-09-08 Miles Laboratories, Inc. Ascorbate resistant composition, test device and method for detecting a component in a liquid test sample
US4290773A (en) * 1979-11-13 1981-09-22 Miles Laboratories, Inc. Stabilization of benzidine-type indicators with various enhancers
US4279993A (en) * 1979-11-13 1981-07-21 Magers Thomas A Indicator composition and test device containing amine oxide, and method of use
US4318984A (en) * 1979-11-13 1982-03-09 Miles Laboratories, Inc. Stabilized composition, test device, and method for detecting the presence of a sugar in a test sample
JPS6091998A (ja) * 1983-10-27 1985-05-23 Yukio Shigeta 体液及び尿中のｄ―３―ヒドロキシ酪酸の測定法並びにそのための測定試薬
JPS60180600A (ja) * 1984-02-29 1985-09-14 Kyowa Medetsukusu Kk 還元型ニコチンアミド・アデニン・ジヌクレオチドの定量方法
JPH0698029B2 (ja) * 1985-12-10 1994-12-07 株式会社三和化学研究所 獣乳の品質検査と乳獣の健康診断とを同時に行う方法
US4898813A (en) * 1986-04-04 1990-02-06 Albarella James P Catalytic test composition intended to produce a range of colors
US4975367A (en) * 1986-04-04 1990-12-04 Miles Inc. Catalytic test composition intended to produce a range of colors
US5041658A (en) * 1986-04-04 1991-08-20 Miles Inc. Carboxamido nitrobenzene disulfide compound
DE3703081A1 (de) * 1987-02-03 1988-08-11 Miles Inc Verfahren und mittel zum nachweis von thiolen
CA1340759C (en) * 1988-07-01 1999-09-21 James P. Albarella Isobenzothiazolone chromogenic thiol indicators and their derivatives
US5190863A (en) * 1990-06-29 1993-03-02 Miles Inc. Composition for determining the presence or concentration of D-β-hydroxybutyrate

Also Published As

Publication number Publication date
EP0463524A1 (en) 1992-01-02
US5190863A (en) 1993-03-02
ATE135052T1 (de) 1996-03-15
DE69117588D1 (de) 1996-04-11
DK0463524T3 (da) 1996-07-22
DE69117588T2 (de) 1996-10-10
JP3118029B2 (ja) 2000-12-18
AU628751B2 (en) 1992-09-17
JPH04237500A (ja) 1992-08-25
AU7926191A (en) 1992-01-02
US5326697A (en) 1994-07-05
EP0463524B1 (en) 1996-03-06
CA2042645A1 (en) 1991-12-30

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