ES2079374T3 - Procedimiento enzimatico de produccion de pentapeptidos inmunomoduladores e intermedios para uso en el procedimiento. - Google Patents
Procedimiento enzimatico de produccion de pentapeptidos inmunomoduladores e intermedios para uso en el procedimiento.Info
- Publication number
- ES2079374T3 ES2079374T3 ES89300369T ES89300369T ES2079374T3 ES 2079374 T3 ES2079374 T3 ES 2079374T3 ES 89300369 T ES89300369 T ES 89300369T ES 89300369 T ES89300369 T ES 89300369T ES 2079374 T3 ES2079374 T3 ES 2079374T3
- Authority
- ES
- Spain
- Prior art keywords
- rest
- amino acid
- amino
- procedure
- pentapeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000027326 copulation Effects 0.000 abstract 1
- TWXDDNPPQUTEOV-UHFFFAOYSA-N hydron;n-methyl-1-phenylpropan-2-amine;chloride Chemical compound Cl.CNC(C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
SINTESIS DE PEPTIDOS R1 - A - B - C - D - E - R2 (EN DONDE A, B, C, D Y E SON RESTOS DE AMINOACIDOS UNIDOS POR ENLACES PEPTIDICOS, SIENDO A UN RESTO DE L - O D - AMINOACIDO BASICO OMEGA - AMINO O - GUANIDINO SUSTITUIDO, O UN DESAMINO DERIVADO SUYO; B ES UN RESTO DE L AMINOACIDO BASICO OMEGA - AMINO O - GUANIDINO SUSTITUIDO, L - PRO O L DESHIDRO - PRO, PREFERIBLEMENTE ASP O GLU; C ES UN RESTO DE L AMINOACIDO NO POLAR, HIDROFOBO, ALIFATICO O AROMATICO ARILICO O ARALQUILICO, PREFERIBLEMENTE VAL, ILE O LEU; E ES UN RESTO DE L - O D - AMINOACIDO DEL MISMO TIPO QUE D O UN DESCARBOXIDERIVADO SUYO, PREFERIBLEMENTE TYR, TRP, PHE, HIS O VAL; R1 ES H O UN GRUPO ALFA AMINO Y R2 ES OH O UN GRUPO ALFA - CARBOXI), POR COPULACION SECUENCIAL DE DERIVADOS REACTIVOS A BASE DE DICHOS AMINOACIDOS EN CONDICIONES DE PH Y EN PRESENCIA DE ENCIMAS. EL PROCESO ES PARTICULARMENTE ADECUADO PARA LA SINTESIS DE LOS PENTAPEPTIDOS INMUNOMODULADORES TISMOPPENTINA Y ESPLENIMIPENTINA Y UTILIZA UNOS COMPUESTOS INTERMEDIOS QUE SE DESCRIBEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK015888A DK15888D0 (da) | 1988-01-14 | 1988-01-14 | Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2079374T3 true ES2079374T3 (es) | 1996-01-16 |
Family
ID=8090415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89300369T Expired - Lifetime ES2079374T3 (es) | 1988-01-14 | 1989-01-16 | Procedimiento enzimatico de produccion de pentapeptidos inmunomoduladores e intermedios para uso en el procedimiento. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0324659B1 (es) |
AT (1) | ATE125819T1 (es) |
AU (1) | AU2943989A (es) |
DE (1) | DE68923625T2 (es) |
DK (2) | DK15888D0 (es) |
ES (1) | ES2079374T3 (es) |
HU (1) | HUT57794A (es) |
IT (1) | IT1223774B (es) |
WO (1) | WO1989006656A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6461834B1 (en) | 1998-11-06 | 2002-10-08 | Bionebraska, Inc. | Clostripain catalyzed amidation of peptides |
CN1669026B (zh) * | 2003-05-17 | 2011-07-06 | 微软公司 | 用于提供文档内容多样重现的系统和方法 |
RU2010114022A (ru) * | 2007-09-11 | 2011-10-20 | Мондобайотек Лабораториз Аг (Li) | Сочетание спленопентина и тимопентина и их применение в лекарственном средстве |
KR20100056516A (ko) * | 2007-09-11 | 2010-05-27 | 몬도바이오테크 래보래토리즈 아게 | 가스트린-1 및 g-pen-grgdspca의 치료적 용도 |
RU2010114010A (ru) * | 2007-09-11 | 2011-10-20 | Мондобайотек Лабораториз Аг (Li) | Применение октреотида в качестве терапевтического средства |
US9708366B2 (en) | 2011-01-27 | 2017-07-18 | Neuren Pharmaceuticals Ltd. | Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1184770C2 (de) * | 1961-06-01 | 1965-09-02 | Hoffmann La Roche | Verfahren zur Herstellung von antibacteriell wirksamen Peptiden |
FI40902B (es) * | 1962-10-12 | 1969-03-31 | Hoffmann La Roche | |
JPS5443076B2 (es) * | 1974-04-24 | 1979-12-18 | ||
FR2294715A1 (fr) * | 1974-12-17 | 1976-07-16 | Inst Rech Scient | Nouveau peptide utilisable en therapeutique et son procede d'obtention |
JPS6339237B2 (es) * | 1979-04-06 | 1988-08-04 | Karuruberugu Baiotekunorojii Ltd As | |
US4361673A (en) * | 1980-09-19 | 1982-11-30 | American Home Products Corporation | Polypeptide compositions |
HU185263B (en) * | 1981-06-12 | 1984-12-28 | Richter Gedeon Vegyeszet | Process for producing peptides effective on the immuncontroll analogous with the tp5 |
JPS5917997A (ja) * | 1982-07-23 | 1984-01-30 | Toyo Soda Mfg Co Ltd | ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法 |
IT1188645B (it) * | 1986-04-09 | 1988-01-20 | Ellem Ind Farmaceutica | Tripeptide ad attivita' immunostimolante |
DE3619633A1 (de) * | 1986-06-11 | 1987-12-17 | Hoechst Ag | Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
EP0288965A2 (de) * | 1987-04-29 | 1988-11-02 | Hoechst Aktiengesellschaft | Peptide mit Phospholipase A2- hemmender Wirkung |
-
1988
- 1988-01-14 DK DK015888A patent/DK15888D0/da not_active Application Discontinuation
- 1988-08-12 IT IT67761/88A patent/IT1223774B/it active
-
1989
- 1989-01-16 WO PCT/DK1989/000005 patent/WO1989006656A1/en unknown
- 1989-01-16 AT AT89300369T patent/ATE125819T1/de not_active IP Right Cessation
- 1989-01-16 HU HU89937A patent/HUT57794A/hu unknown
- 1989-01-16 EP EP89300369A patent/EP0324659B1/en not_active Expired - Lifetime
- 1989-01-16 AU AU29439/89A patent/AU2943989A/en not_active Abandoned
- 1989-01-16 ES ES89300369T patent/ES2079374T3/es not_active Expired - Lifetime
- 1989-01-16 DE DE68923625T patent/DE68923625T2/de not_active Expired - Lifetime
-
1990
- 1990-07-13 DK DK169090A patent/DK169090A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0324659B1 (en) | 1995-08-02 |
EP0324659A2 (en) | 1989-07-19 |
DK169090A (da) | 1990-09-14 |
IT8867761A0 (it) | 1988-08-12 |
HU890937D0 (en) | 1991-11-28 |
EP0324659A3 (en) | 1991-04-03 |
ATE125819T1 (de) | 1995-08-15 |
HUT57794A (en) | 1991-12-30 |
DE68923625D1 (de) | 1995-09-07 |
WO1989006656A1 (en) | 1989-07-27 |
IT1223774B (it) | 1990-09-29 |
DK15888D0 (da) | 1988-01-14 |
DK169090D0 (da) | 1990-07-13 |
DE68923625T2 (de) | 1996-03-28 |
AU2943989A (en) | 1989-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ331895A (en) | Hemoglobin alpha chain polypeptide as inhibitor and stimulator of stem cell proliferation | |
AU4188789A (en) | Urethane-protected amino acid-n-carboxyanhydrides | |
PT883687E (pt) | Receptores de quimiocinas c-c, ckr-5, cc, os seus derivados e as suas utilizacoes | |
WO1998020133A3 (en) | Proteins with enhanced levels of essential amino acids | |
DE59007517D1 (de) | Neue proteine mit tnf-hemmender wirkung und ihre herstellung. | |
MC2144A1 (fr) | Peptides therapeutiques | |
RU94036776A (ru) | Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы | |
ES2079374T3 (es) | Procedimiento enzimatico de produccion de pentapeptidos inmunomoduladores e intermedios para uso en el procedimiento. | |
SE8901552L (sv) | Syraadditionssalter av amiderat taurin eller glycin, deras framstaellning och anvaendning | |
ES2058479T3 (es) | Compuestos peptidicos. | |
AR009600A1 (es) | Secuencia de acido nucleico y aminoacidos relacionados con helicobacter pylori y composiciones de vacuna de la misma. | |
ES2058873T3 (es) | Antagonistas peptidicos sinteticos de neuroquinina a, sus sales y procedimientos de preparacion respectivos. | |
HK1013951A1 (en) | Production and use of anthelmintic agents and protective immunogens | |
AR246085A1 (es) | Procedimiento para preparar derivados peptidicos antagonistas de neuroquinina a. | |
DE3782880D1 (de) | Hemmende peptide. | |
ATE124955T1 (de) | Substrat-peptide. | |
ATE50267T1 (de) | Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren. | |
DE3686257D1 (de) | Herstellung von polypeptiden. | |
DK0717048T3 (da) | Cyclohexapeptider og deres blandinger, fremgangsmåde til fremstilling deraf samt deres anvendelse | |
ES2163921T3 (es) | Substancia con actividad renina que contiene prorrenina humana y los anticuerpos contra el profragmento de prorrenina. | |
DE60038310D1 (de) | Menschliche antithrombin-varianten | |
MX9206217A (es) | Endopeptidas novedosas, su actividad en la segmentacion y la inactividad de substractos peptidicos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 324659 Country of ref document: ES |