ES2077101T3 - Conjugados de un hapteno y biotina y su utilizacion. - Google Patents

Conjugados de un hapteno y biotina y su utilizacion.

Info

Publication number
ES2077101T3
ES2077101T3 ES91105678T ES91105678T ES2077101T3 ES 2077101 T3 ES2077101 T3 ES 2077101T3 ES 91105678 T ES91105678 T ES 91105678T ES 91105678 T ES91105678 T ES 91105678T ES 2077101 T3 ES2077101 T3 ES 2077101T3
Authority
ES
Spain
Prior art keywords
hapten
biotin
conjugates
turbidimetric
agglutination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91105678T
Other languages
English (en)
Inventor
Erasmus Dr Huber
Dietmar Dr Zdunek
Christian Dr Klein
Roland Dr Schenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2077101T3 publication Critical patent/ES2077101T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F210/00—Copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

SE TRATA DE UN CONJUGADO DE HAPTENO-BIOTINA EN EL QUE EL HAPTENO ESTA UNIDO CON LA BIOTINA A TRAVES DE UN SPACER, QUE SE MUESTRA EN UNA CADENA DE 26 A 40 ATOMOS Y AL MENOS CONTIENE 5 ETEROATOMOS. ESTOS CONJUGADOS SON NUEVOS Y APROPIADOS ESPECIALMENTE PARA SU UTILIZACION EN UN INMUNOASAY HOMOGENEO COMPETITIVO, DONDE LA AGLUTINACION APARECIDA EN LA REACCION SE VALORA A TRAVES DE MEDIDAS TURBIDIMETRICAS O NEFELOMETRICAS.
ES91105678T 1990-04-10 1991-04-10 Conjugados de un hapteno y biotina y su utilizacion. Expired - Lifetime ES2077101T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011601A DE4011601A1 (de) 1990-04-10 1990-04-10 Hapten-biotin-konjugate und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2077101T3 true ES2077101T3 (es) 1995-11-16

Family

ID=6404148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91105678T Expired - Lifetime ES2077101T3 (es) 1990-04-10 1991-04-10 Conjugados de un hapteno y biotina y su utilizacion.

Country Status (8)

Country Link
US (1) US5219764A (es)
EP (1) EP0451810B1 (es)
JP (1) JPH082910B2 (es)
KR (1) KR910018419A (es)
AT (1) ATE126595T1 (es)
DE (2) DE4011601A1 (es)
DK (1) DK0451810T3 (es)
ES (1) ES2077101T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534620A (en) * 1987-09-30 1996-07-09 Beckman Instruments, Inc. Method of heterogenous purification using a bidentate conjugate
DE4239429A1 (de) * 1992-11-24 1994-05-26 Merck Patent Gmbh Verfahren zur Herstellung von Immunkonjugaten
WO1994016330A1 (en) * 1993-01-06 1994-07-21 Beckman Instruments, Inc. Method for making a preconjugate
US5536820A (en) * 1993-02-26 1996-07-16 E. I. Du Pont De Nemours And Company Avidin-binding azo reagents
EP0640836A3 (en) * 1993-08-24 1995-12-20 Wako Pure Chem Ind Ltd Immunoassay.
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
US5747352A (en) * 1994-05-23 1998-05-05 Beckman Instruments, Inc. Reagents and methods for the rapid and quantitative assay of pharmacological agents
DE69533105T2 (de) * 1994-06-06 2005-06-09 The Jmde Trust, Newton Biotinverbindungen zum zielen auf tumore und infektionsherde
US5716594A (en) * 1994-06-06 1998-02-10 The Jmde Trust Biotin compounds for targetting tumors and sites of infection
DE59607898D1 (de) † 1995-12-29 2001-11-15 Biotez Berlin Buch Gmbh Bioche Verfahren zur markierung von biomolekülen mit meerrettichperoxidase
DE19748489A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6153442A (en) * 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
JP2002296281A (ja) * 2001-03-07 2002-10-09 F Hoffmann La Roche Ag 改良された均一系イムノアッセイ法
US7145019B2 (en) * 2003-10-16 2006-12-05 Ambergen, Inc. Photocleavable isotope-coded affinity tags
US20090136522A1 (en) * 2006-03-24 2009-05-28 Haynes Barton F Multivalent Immunogen
JP2010053118A (ja) * 2008-07-28 2010-03-11 Fujifilm Corp ビオチン化チロキシン
CN113721012B (zh) * 2021-08-27 2022-08-09 深圳上泰生物工程有限公司 一种组合物及其试剂盒在检测甘胆酸中的用途
CN118265723A (zh) 2021-11-11 2024-06-28 豪夫迈·罗氏有限公司 针对l-甲状腺素的新颖单克隆抗体及其诊断用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617261A (en) * 1984-03-21 1986-10-14 Cetus Corporation Process for labeling nucleic acids and hybridization probes
NZ211453A (en) * 1984-03-22 1989-01-06 Biotechnology Research Enterpr Aryl azides, their preparation and use in the detection, localisation and isolation of polynucleotides
DE3586314D1 (de) * 1984-11-27 1992-08-13 Behringwerke Ag Bifunktionelle haptene, verfahren zu ihrer herstellung und ihre verwendung.
US4760142A (en) * 1984-11-27 1988-07-26 Hoechst Celanese Corporation Divalent hapten derivatives
EP0310361A3 (en) * 1987-09-30 1989-05-24 Beckman Instruments, Inc. Tridentate conjugate and method of use thereof
DE3882904T2 (de) * 1987-09-30 1993-11-18 Beckman Instruments Inc Aus zwei Verzahnungen bestehendes Konjugat und Verfahren zu seiner Verwendung.
DE3822750A1 (de) * 1988-07-05 1990-01-11 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Also Published As

Publication number Publication date
JPH04224583A (ja) 1992-08-13
JPH082910B2 (ja) 1996-01-17
DE59106246D1 (de) 1995-09-21
EP0451810A1 (de) 1991-10-16
DE4011601A1 (de) 1991-10-17
US5219764A (en) 1993-06-15
DK0451810T3 (da) 1996-01-02
KR910018419A (ko) 1991-11-30
ATE126595T1 (de) 1995-09-15
EP0451810B1 (de) 1995-08-16

Similar Documents

Publication Publication Date Title
ES2077101T3 (es) Conjugados de un hapteno y biotina y su utilizacion.
DK0897983T3 (da) Antistoffer mod CD40-L
DE69127036D1 (de) Halbleiter mit verbessertem Prüfmodus
DE69029995D1 (de) Multiprozessor mit relativ atomaren Befehlen
DE59008361D1 (de) Polycyclische 3-Aryl-pyrrolidin-2,4,-dion-Derivate.
LU90842I2 (fr) Mabcampath-alemtuzumab et ses d-riv-s pharmaceutiquement acceptables
IT8920259A0 (it) Sensore con antigene legato chimicamente a un dispositivo semiconduttore.
DE3882497D1 (de) Hochfrequenz-leistungssensor mit grossem dynamischen bereich.
EP0359063A3 (en) Antibody having high affinity to hapten as antigen and immunogen for obtaining the same
DE3883445D1 (de) Interferometersensor mit zeitaufgelösten Messungen.
NO924296L (no) Anordning for oppdeling av en samling av avlange stykker av tre, og stykkevis tverrmating av disse i en retning frasamlingsplassen
DE69128596D1 (de) Transkonduktanzstufe mit breitem dynamischen Bereich
ATE23638T1 (de) Lichtelektrische inkrementale laengen- oder winkelmesseinrichtung.
DK286879A (da) Doerlaas med noeglebetjent laasecylinder
DK260589D0 (da) Beholder med skruelukke, der er vanskeligt for boern at aabne
BR8101322A (pt) Composicoes de aclaradores oticos
FI923847A0 (fi) Foerfarande foer framstaellning av 2-(metyltio)-dinatriumbarbiturat.
PT70791A (fr) Capteur solaire
ES2083478T3 (es) Antagonistas de nmda heterociclicos.
DE58908442D1 (de) Monoazoverbindungen mit langkettigen Alkylresten.
DE69203735D1 (de) Interferometrische Vorrichtung, insbesondere Stellarinterferometer, mit Laufzeitkette.
PT90209A (pt) Bases de dados relacionais
BE878099A (fr) Capteur solaire
AT362632B (de) Spannvorrichtung fuer kettenstraenge
BR9003749A (pt) Disposicao com um componente semi condutor

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 451810

Country of ref document: ES