ES2076642T3 - Procedimiento para la mono-orto-hidroxialquilacion selectiva de derivados de piridina sustituidos en posicion 4. - Google Patents

Procedimiento para la mono-orto-hidroxialquilacion selectiva de derivados de piridina sustituidos en posicion 4.

Info

Publication number
ES2076642T3
ES2076642T3 ES92115832T ES92115832T ES2076642T3 ES 2076642 T3 ES2076642 T3 ES 2076642T3 ES 92115832 T ES92115832 T ES 92115832T ES 92115832 T ES92115832 T ES 92115832T ES 2076642 T3 ES2076642 T3 ES 2076642T3
Authority
ES
Spain
Prior art keywords
procedure
hydroxialkylation
ortho
selective mono
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92115832T
Other languages
English (en)
Inventor
Bernd Dr Scharbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2076642T3 publication Critical patent/ES2076642T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION DE UN DERIVADO DE PIRIDINA DE ACUERDO CON LA FORMULA GENERAL II. PARA ELLO, SE REALIZA EN EL DERIVADO DE PIRIDINA PROTONIZADO, DE ACUERDO CON LA FORMULA GENERAL I, BAJO ACCION DEL DISULFATO DE PEROXIDO UNA HIDROXIALQUILACION NUCLEOFILA.
ES92115832T 1991-09-19 1992-09-16 Procedimiento para la mono-orto-hidroxialquilacion selectiva de derivados de piridina sustituidos en posicion 4. Expired - Lifetime ES2076642T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4131217 1991-09-19

Publications (1)

Publication Number Publication Date
ES2076642T3 true ES2076642T3 (es) 1995-11-01

Family

ID=6441003

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92115832T Expired - Lifetime ES2076642T3 (es) 1991-09-19 1992-09-16 Procedimiento para la mono-orto-hidroxialquilacion selectiva de derivados de piridina sustituidos en posicion 4.

Country Status (9)

Country Link
US (1) US5693819A (es)
EP (1) EP0533131B1 (es)
JP (1) JP3151786B2 (es)
AT (1) ATE126214T1 (es)
CA (1) CA2078585A1 (es)
DE (1) DE59203209D1 (es)
DK (1) DK0533131T3 (es)
ES (1) ES2076642T3 (es)
GR (1) GR3017398T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
WO1999033807A2 (en) * 1997-12-24 1999-07-08 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives (intermediates) employing free radical substitution reactions to functionalize the 2-position of the pyridine

Also Published As

Publication number Publication date
CA2078585A1 (en) 1993-03-19
ATE126214T1 (de) 1995-08-15
JP3151786B2 (ja) 2001-04-03
EP0533131B1 (de) 1995-08-09
JPH05194399A (ja) 1993-08-03
EP0533131A1 (de) 1993-03-24
DK0533131T3 (da) 1995-12-04
GR3017398T3 (en) 1995-12-31
US5693819A (en) 1997-12-02
DE59203209D1 (de) 1995-09-14

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