ES2076522T3 - Radicales triarilmetilicos y el uso de radicales libres de carbono inertes en mri. - Google Patents

Radicales triarilmetilicos y el uso de radicales libres de carbono inertes en mri.

Info

Publication number
ES2076522T3
ES2076522T3 ES91903934T ES91903934T ES2076522T3 ES 2076522 T3 ES2076522 T3 ES 2076522T3 ES 91903934 T ES91903934 T ES 91903934T ES 91903934 T ES91903934 T ES 91903934T ES 2076522 T3 ES2076522 T3 ES 2076522T3
Authority
ES
Spain
Prior art keywords
radicals
sample
triarilmetilic
mri
free radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91903934T
Other languages
English (en)
Inventor
Mikkel Jorgensen
Frode Rise
Sven Andersson
Torsten Almen
Arne Aabye
Lars-Goran Wistrand
Hakan Wikstrom
Klaes Golman
Rolf Servin
Peter Michelsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health R&D AB
Original Assignee
Nycomed Innovation AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909003105A external-priority patent/GB9003105D0/en
Priority claimed from GB909012300A external-priority patent/GB9012300D0/en
Application filed by Nycomed Innovation AB filed Critical Nycomed Innovation AB
Application granted granted Critical
Publication of ES2076522T3 publication Critical patent/ES2076522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

LA INVENCION SE REFIERE AL USO DE RADICALES LIBRES ESTABLES DE CARBONO COMO AGENTES INTENSIFICADORES DE IMAGEN EN OVERHAUSER MRI.
ES91903934T 1990-02-12 1991-02-12 Radicales triarilmetilicos y el uso de radicales libres de carbono inertes en mri. Expired - Lifetime ES2076522T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909003105A GB9003105D0 (en) 1990-02-12 1990-02-12 Compositions
GB909012300A GB9012300D0 (en) 1990-06-01 1990-06-01 Compositions

Publications (1)

Publication Number Publication Date
ES2076522T3 true ES2076522T3 (es) 1995-11-01

Family

ID=26296651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91903934T Expired - Lifetime ES2076522T3 (es) 1990-02-12 1991-02-12 Radicales triarilmetilicos y el uso de radicales libres de carbono inertes en mri.

Country Status (14)

Country Link
US (2) US5599522A (es)
EP (1) EP0515458B1 (es)
JP (1) JP3175940B2 (es)
AT (1) ATE126707T1 (es)
AU (1) AU651570B2 (es)
CA (1) CA2075818A1 (es)
DE (1) DE69112384T2 (es)
DK (1) DK0515458T3 (es)
ES (1) ES2076522T3 (es)
FI (1) FI923589A0 (es)
GR (1) GR3017947T3 (es)
IE (1) IE69365B1 (es)
NO (1) NO923117L (es)
WO (1) WO1991012024A1 (es)

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GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
US5435991A (en) * 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
GB9117258D0 (en) * 1991-08-09 1991-09-25 Hafslund Nycomed Innovation Use of radicals
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals
WO1998022148A1 (en) * 1996-11-20 1998-05-28 Washington University Mri contrast agents and ligands
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
DE10029075A1 (de) * 2000-06-13 2001-12-20 Bayer Ag Verfahren zur Herstellung von 3,4-Alkylendioxythiophen-2,5-dicarbonsäurederivaten
NL1017122C2 (nl) * 2001-01-16 2002-07-17 Doornes Transmissie Bv Dwarselement voor een drijfriem voor een continu variabele transmissie.
US7126332B2 (en) * 2001-07-20 2006-10-24 Baker Hughes Incorporated Downhole high resolution NMR spectroscopy with polarization enhancement
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
JP5367265B2 (ja) 2004-07-30 2013-12-11 ジーイー・ヘルスケア・アクスイェ・セルスカプ 組成物の製造方法、組成物及びその使用
AU2005267670B2 (en) * 2004-07-30 2011-03-03 Ge Healthcare As Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process
JP2009510081A (ja) * 2005-09-28 2009-03-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 磁気共鳴イメージングにおける造影剤としての使用のための長いスピン緩和時間を有する過分極化された固形物
NO20055681D0 (no) * 2005-12-01 2005-12-01 Amersham Health As Method of dynamic nuclear polarisation
WO2007064226A2 (en) 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
EP1960001A2 (en) 2005-12-08 2008-08-27 Koninklijke Philips Electronics N.V. System and method for monitoring in vivo drug release using overhauser-enhanced nmr
WO2007070466A2 (en) * 2005-12-10 2007-06-21 The President And Fellows Of Harvard College In situ hyperpolarization of imaging agents
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
JP2009523172A (ja) * 2006-01-11 2009-06-18 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 造影剤のエクスビボ過分極
WO2007136439A2 (en) 2006-02-21 2007-11-29 Avrum Belzer Hyperpolarization methods, systems and compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
CN101415446A (zh) * 2006-03-29 2009-04-22 通用电气医疗集团股份有限公司 生产超极化的羧酸盐和磺酸盐的方法
ES2432393T3 (es) 2006-08-30 2013-12-03 Ge Healthcare As Procedimiento de polarización nuclear dinámica (PND), y compuestos y composiciones para su uso en el procedimiento
EP2135911B1 (en) 2007-03-30 2014-05-28 FUJIFILM Corporation Ultraviolet ray absorber composition
CN101821273A (zh) 2007-08-16 2010-09-01 富士胶片株式会社 杂环化合物、紫外线吸收剂、以及含有该紫外线吸收剂的组合物
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP2010059235A (ja) 2008-09-01 2010-03-18 Fujifilm Corp 紫外線吸収剤組成物
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
US8593141B1 (en) 2009-11-24 2013-11-26 Hypres, Inc. Magnetic resonance system and method employing a digital squid
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
EP2399913B1 (de) * 2010-06-25 2013-09-18 Universität Potsdam Fluoreszenzfarbstoff und seine Verwendung
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
JP6026824B2 (ja) * 2012-09-04 2016-11-16 紀本電子工業株式会社 芳香族ニトロ化合物のラジカルアニオンの製造方法
JP7427354B2 (ja) 2018-01-29 2024-02-05 日清オイリオグループ株式会社 炊飯用油脂組成物、飯類、及び飯類の製造方法

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* Cited by examiner, † Cited by third party
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DE3328365A1 (de) * 1983-08-03 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Neue diagnostische mittel
DE3851442T2 (de) * 1987-06-23 1995-01-19 Nycomed Innovation Ab Verbesserungen bei der Bilderzeugung mittels magnetischer Resonanz.
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus

Also Published As

Publication number Publication date
JPH05506428A (ja) 1993-09-22
IE69365B1 (en) 1996-09-04
NO923117D0 (no) 1992-08-11
NO923117L (no) 1992-10-08
JP3175940B2 (ja) 2001-06-11
US5827501A (en) 1998-10-27
DE69112384T2 (de) 1996-03-28
DK0515458T3 (da) 1995-09-25
CA2075818A1 (en) 1991-08-13
DE69112384D1 (de) 1995-09-28
US5599522A (en) 1997-02-04
WO1991012024A1 (en) 1991-08-22
EP0515458A1 (en) 1992-12-02
FI923589A (fi) 1992-08-11
IE910462A1 (en) 1991-08-14
ATE126707T1 (de) 1995-09-15
GR3017947T3 (en) 1996-02-29
EP0515458B1 (en) 1995-08-23
FI923589A0 (fi) 1992-08-11
AU7235091A (en) 1991-09-03
AU651570B2 (en) 1994-07-28

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