ES2071626T3 - Anticuerpo monoclonal de raton contra la proteina gp41 del virus de inmunodeficiencia humana. - Google Patents

Anticuerpo monoclonal de raton contra la proteina gp41 del virus de inmunodeficiencia humana.

Info

Publication number
ES2071626T3
ES2071626T3 ES89103859T ES89103859T ES2071626T3 ES 2071626 T3 ES2071626 T3 ES 2071626T3 ES 89103859 T ES89103859 T ES 89103859T ES 89103859 T ES89103859 T ES 89103859T ES 2071626 T3 ES2071626 T3 ES 2071626T3
Authority
ES
Spain
Prior art keywords
monoclonal antibody
protein
human immunodeficiency
viruses
mouse against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89103859T
Other languages
English (en)
Inventor
Jeffrey C Hunt
George J Dawson
Virender K Sarin
Larry K Wray
Sushil G Devare
J Scott Webber
Lawrence A Falk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2071626T3 publication Critical patent/ES2071626T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

El procedimiento para producir un anticuerpo monoclonal, que comprende las etapas de: a) inmunizar a un mamífero con antígeno de VIH I; b) demostrar producción de anticuerpo anti VIH I específico por dicho mamífero inmunizado; y c) fusionar las células de bazo de dicho mamífero inmunizado con una línea celular de mieloma, con lo que se forma un hibridoma que secreta anticuerpo anti VIH I, en el que dicho anticuerpo se caracteriza por su especificidad hacia un epítope sobre gp41 de VIH I formado por una primera secuencia de aminoácidos Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu-Leu Leu Glu-Leu Asp Lys con al menos una segunda secuencia de aminoácidos flanqueante, de al menos 5 aminoácidos de longitud, 3'' al extremo carboxi, o bien 5'' al extremo amino de dicha primera secuencia, teniendo dicha secuencia flanqueante una secuencia de aminoácidos correspondiente a gp41 de VIH nativo, en que dicha secuencia flanqueante pone dicha primera secuencia en conformación antigénica conveniente.
ES89103859T 1988-03-30 1989-03-06 Anticuerpo monoclonal de raton contra la proteina gp41 del virus de inmunodeficiencia humana. Expired - Lifetime ES2071626T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17607788A 1988-03-30 1988-03-30

Publications (1)

Publication Number Publication Date
ES2071626T3 true ES2071626T3 (es) 1995-07-01

Family

ID=22642881

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89103859T Expired - Lifetime ES2071626T3 (es) 1988-03-30 1989-03-06 Anticuerpo monoclonal de raton contra la proteina gp41 del virus de inmunodeficiencia humana.

Country Status (7)

Country Link
EP (1) EP0335134B1 (es)
JP (1) JP2954597B2 (es)
AT (1) ATE119203T1 (es)
AU (1) AU608413B2 (es)
CA (1) CA1339489C (es)
DE (1) DE68921360T2 (es)
ES (1) ES2071626T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0362910A3 (en) * 1988-08-27 1991-01-09 Akzo N.V. Synthetic peptides immunochemically reactive with hiv-antibodies
JPH0292298A (ja) * 1988-09-30 1990-04-03 Olympus Optical Co Ltd Ｈｉｖ構成蛋白に対するモノクローナル抗体
US6248574B1 (en) * 1989-12-13 2001-06-19 Avigdor Shaffermann Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
GB9410044D0 (en) * 1994-05-19 1994-07-06 Int Murex Tech Corp Assay
DE19622088A1 (de) * 1996-05-31 1997-12-04 Boehringer Mannheim Gmbh Anti-HIV-Antikörper als Kontrollproben
US6596497B1 (en) 1999-03-17 2003-07-22 New York Blood Center, Inc. Screening of antiviral compounds targeted to the HIV-1 gp41 core structure
ATE516048T1 (de) 2004-06-01 2011-07-15 Merck Sharp & Dohme Mit hiv gp41 in wechselwirkung stehende menschliche antikörper
WO2017093985A1 (en) 2015-12-05 2017-06-08 Centre Hospitalier Universitaire Vaudois Hiv binding agents
WO2020012435A1 (en) 2018-07-13 2020-01-16 Lausanne University Hospital Hiv binding agents
US20220267416A1 (en) 2019-07-15 2022-08-25 Lausanne University Hospital Hiv binding agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5831673B2 (ja) * 1979-08-22 1983-07-07 富士通株式会社 半導体記憶装置
JP2702911B2 (ja) * 1985-09-11 1998-01-26 ユナイテツド・バイオメデイカル・インコ−ポレ−テツド 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
US4904581A (en) * 1986-05-06 1990-02-27 Epitope, Inc. Method of detecting AIDS virus infection

Also Published As

Publication number Publication date
DE68921360D1 (de) 1995-04-06
DE68921360T2 (de) 1995-09-28
ATE119203T1 (de) 1995-03-15
AU3021989A (en) 1989-10-05
EP0335134A2 (en) 1989-10-04
JPH02119794A (ja) 1990-05-07
AU608413B2 (en) 1991-03-28
CA1339489C (en) 1997-10-07
EP0335134B1 (en) 1995-03-01
EP0335134A3 (en) 1991-06-26
JP2954597B2 (ja) 1999-09-27

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