ES2071135T3 - Procedimientos selectivos para polimorfos de fosinopril. - Google Patents
Procedimientos selectivos para polimorfos de fosinopril.Info
- Publication number
- ES2071135T3 ES2071135T3 ES91101663T ES91101663T ES2071135T3 ES 2071135 T3 ES2071135 T3 ES 2071135T3 ES 91101663 T ES91101663 T ES 91101663T ES 91101663 T ES91101663 T ES 91101663T ES 2071135 T3 ES2071135 T3 ES 2071135T3
- Authority
- ES
- Spain
- Prior art keywords
- polymorph
- fosinopril
- water
- polymorphes
- exothermic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 title abstract 3
- 229960002490 fosinopril Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 229930194542 Keto Natural products 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA PREPARAR E INTERCONVERTIR SELECTIVAMENTE SALES POLIMORFAS DE FOSINOPRIL, AGENTE ANTIHIPERTENSIVO QUE INHIBE LA ENZIMA CONVERSORA DE LA ANGIOTENSINA. CADA POLIMORFO SE PREPARA MEZCLANDO UN PORTADOR DE METAL ALCALI, FOSINOCRIL, AGUA Y QUETO Y/O UN SOLVENTE HIDROXILICO Y AISLANDO EL POLIMORFO FORMADO A PARTIR DE LA MEZCLA DE REACCION. UN POLIMORFO A MENOS EXOTERMICO SE FORMA CUANDO EL AGUA COMPONE MAS DEL 0.2 % DEL AGUA Y LOS SOLVENTES; CUANDO COMPONE EL 0.2 % O MENOS, SE FORMA EL POLIMORFO B.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/481,009 US5162543A (en) | 1990-02-16 | 1990-02-16 | Selective processes for fosinopril polymorphs |
| AU75286/91A AU646032B2 (en) | 1990-02-16 | 1991-04-23 | Selective processes for fosinopril polymorphs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2071135T3 true ES2071135T3 (es) | 1995-06-16 |
Family
ID=25637879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91101663T Expired - Lifetime ES2071135T3 (es) | 1990-02-16 | 1991-02-07 | Procedimientos selectivos para polimorfos de fosinopril. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5162543A (es) |
| EP (1) | EP0442378B1 (es) |
| JP (1) | JP2938590B2 (es) |
| AT (1) | ATE121411T1 (es) |
| AU (1) | AU646032B2 (es) |
| CA (1) | CA2034811C (es) |
| DE (1) | DE69108953T2 (es) |
| DK (1) | DK0442378T3 (es) |
| ES (1) | ES2071135T3 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9206414D0 (en) * | 1992-03-24 | 1992-05-06 | Smithkline Beecham Corp | N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph b |
| WO2002088149A2 (en) * | 2001-04-30 | 2002-11-07 | Lupin Laboratories Limited | A process for manufacture of fosinopril sodium |
| ES2195752B1 (es) * | 2001-11-30 | 2004-10-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de polimorfos cristalinos de la sal sodica del fosinopril. |
| SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
| CN107365268B (zh) * | 2016-05-11 | 2021-02-05 | 常州制药厂有限公司 | 一种降压药福辛普利钠及其关键中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337201A (en) * | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4734508A (en) * | 1987-05-01 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Process and intermediates for preparing 4-substituted proline derivatives |
-
1990
- 1990-02-16 US US07/481,009 patent/US5162543A/en not_active Expired - Lifetime
-
1991
- 1991-01-23 CA CA002034811A patent/CA2034811C/en not_active Expired - Lifetime
- 1991-02-07 AT AT91101663T patent/ATE121411T1/de not_active IP Right Cessation
- 1991-02-07 EP EP91101663A patent/EP0442378B1/en not_active Expired - Lifetime
- 1991-02-07 ES ES91101663T patent/ES2071135T3/es not_active Expired - Lifetime
- 1991-02-07 DK DK91101663.2T patent/DK0442378T3/da active
- 1991-02-07 DE DE69108953T patent/DE69108953T2/de not_active Expired - Lifetime
- 1991-02-16 JP JP2241391A patent/JP2938590B2/ja not_active Expired - Lifetime
- 1991-04-23 AU AU75286/91A patent/AU646032B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU7528691A (en) | 1992-10-29 |
| CA2034811C (en) | 2001-04-03 |
| JPH04211093A (ja) | 1992-08-03 |
| DE69108953D1 (de) | 1995-05-24 |
| DE69108953T2 (de) | 1995-10-19 |
| EP0442378A1 (en) | 1991-08-21 |
| ATE121411T1 (de) | 1995-05-15 |
| EP0442378B1 (en) | 1995-04-19 |
| CA2034811A1 (en) | 1991-08-17 |
| DK0442378T3 (da) | 1995-10-02 |
| AU646032B2 (en) | 1994-02-03 |
| US5162543A (en) | 1992-11-10 |
| JP2938590B2 (ja) | 1999-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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