ES2070536T3 - Saliciloil-carnitina y procedimiento para su preparacion. - Google Patents
Saliciloil-carnitina y procedimiento para su preparacion.Info
- Publication number
- ES2070536T3 ES2070536T3 ES92101618T ES92101618T ES2070536T3 ES 2070536 T3 ES2070536 T3 ES 2070536T3 ES 92101618 T ES92101618 T ES 92101618T ES 92101618 T ES92101618 T ES 92101618T ES 2070536 T3 ES2070536 T3 ES 2070536T3
- Authority
- ES
- Spain
- Prior art keywords
- carnitine
- saliciloil
- procedure
- preparation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBEN ESTERES DEL ACIDO SALICILICO DE LA CARNITINA. LOS COMPUESTOS SE CARACTERIZAN CON RELACION AL ACIDO ACETILSALICILICO A TRAVES DE UNA ALTA SOLUBILIDAD EN AGUA, TOXICIDAD DISMINUIDA Y BUENA TOLERANCIA EN EL ESTOMAGO Y SON OBTENIBLES EN TRES ETAPAS A PARTIR DEL HIDROCLORHIDRICO-CARNITINA Y O OXIBENZOIL CLORHIDRICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2222/90A CH679856A5 (es) | 1990-07-04 | 1990-07-04 | |
CH2999/90A CH679395A5 (es) | 1990-07-04 | 1990-09-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2070536T3 true ES2070536T3 (es) | 1995-06-01 |
Family
ID=40316909
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92101618T Expired - Lifetime ES2070536T3 (es) | 1990-07-04 | 1992-01-31 | Saliciloil-carnitina y procedimiento para su preparacion. |
ES92101617T Expired - Lifetime ES2070535T3 (es) | 1990-07-04 | 1992-01-31 | Acetilsaliciloil-carnitina y procedimiento para su preparacion. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92101617T Expired - Lifetime ES2070535T3 (es) | 1990-07-04 | 1992-01-31 | Acetilsaliciloil-carnitina y procedimiento para su preparacion. |
Country Status (4)
Country | Link |
---|---|
US (2) | US5227513A (es) |
EP (2) | EP0553384B1 (es) |
CH (2) | CH679856A5 (es) |
ES (2) | ES2070536T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH679856A5 (es) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
IL105244A (en) * | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
US6413949B1 (en) | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
IT1261696B (it) * | 1993-06-02 | 1996-05-29 | Avantgarde Spa | Uso di esteri sull'ossidrile della l-carnitina con acidi aromatici perprodurre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
US6313106B1 (en) | 1995-06-07 | 2001-11-06 | D-Pharm Ltd. | Phospholipid derivatives of valproic acid and mixtures thereof |
IT1306184B1 (it) * | 1999-08-05 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Nitrilossi derivati della (r) e (s)-carnitina. |
WO2010151095A1 (en) * | 2009-06-25 | 2010-12-29 | Tetra, Sia | Novel acetylsalicylic acid salts |
WO2018041804A1 (de) | 2016-08-30 | 2018-03-08 | Drug'on Pharma Switzerland Ag | Verfahren zur herstellung von salicyloyl-l-carnitin-hydrochlorid |
EP3326999B1 (de) | 2016-11-24 | 2019-08-07 | Drug'On Pharma Switzerland AG | Salicyloylcarnitin sulfonate |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH389641A (de) * | 1961-01-20 | 1965-03-31 | Mundipharma Ag | Verfahren zur Herstellung von Betainsalicylat |
US4336400A (en) * | 1969-04-01 | 1982-06-22 | Sterling Drug Inc. | 3-(Hydroxy or hydroxymethyl)-4-hydroxy-alpha(aminomethyl)benzyl alcohols and methods of use |
DE2914721A1 (de) * | 1978-04-17 | 1979-10-18 | Kyowa Hakko Kogyo Kk | Verfahren zur bestimmung der cholinesterase-aktivitaet sowie fuer dieses verfahren verwendbare cholin-derivate |
IT1156840B (it) * | 1978-06-27 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Acil derivati della carnitina |
US4402974A (en) * | 1981-06-23 | 1983-09-06 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
CH679856A5 (es) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
JPH0721352A (ja) * | 1993-07-05 | 1995-01-24 | Hitachi Ltd | 分散オーサリング・システム |
-
1990
- 1990-07-04 CH CH2222/90A patent/CH679856A5/de not_active IP Right Cessation
- 1990-09-17 CH CH2999/90A patent/CH679395A5/de not_active IP Right Cessation
-
1992
- 1992-01-31 ES ES92101618T patent/ES2070536T3/es not_active Expired - Lifetime
- 1992-01-31 EP EP92101617A patent/EP0553384B1/de not_active Expired - Lifetime
- 1992-01-31 ES ES92101617T patent/ES2070535T3/es not_active Expired - Lifetime
- 1992-01-31 EP EP92101618A patent/EP0553385B1/de not_active Expired - Lifetime
- 1992-02-11 US US07/833,673 patent/US5227513A/en not_active Expired - Lifetime
- 1992-02-11 US US07/833,672 patent/US5227514A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0553385B1 (de) | 1995-03-29 |
US5227513A (en) | 1993-07-13 |
US5227514A (en) | 1993-07-13 |
EP0553385A1 (de) | 1993-08-04 |
ES2070535T3 (es) | 1995-06-01 |
EP0553384A1 (de) | 1993-08-04 |
EP0553384B1 (de) | 1995-03-29 |
CH679856A5 (es) | 1992-04-30 |
CH679395A5 (es) | 1992-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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