ES2070276T3 - Lactonas macrociclicas inhibidoras del crecimiento celular denominadas combretastatina d-2. - Google Patents

Lactonas macrociclicas inhibidoras del crecimiento celular denominadas combretastatina d-2.

Info

Publication number
ES2070276T3
ES2070276T3 ES90304290T ES90304290T ES2070276T3 ES 2070276 T3 ES2070276 T3 ES 2070276T3 ES 90304290 T ES90304290 T ES 90304290T ES 90304290 T ES90304290 T ES 90304290T ES 2070276 T3 ES2070276 T3 ES 2070276T3
Authority
ES
Spain
Prior art keywords
combretastatin
cell growth
macrocyclic
lactons
called
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90304290T
Other languages
English (en)
Inventor
George R Pettit
Sheo Bux Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona Board of Regents of University of Arizona
University of Arizona
Original Assignee
Arizona Board of Regents of University of Arizona
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arizona Board of Regents of University of Arizona, University of Arizona filed Critical Arizona Board of Regents of University of Arizona
Application granted granted Critical
Publication of ES2070276T3 publication Critical patent/ES2070276T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Lubricants (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTA EL AISLAMIENTO Y ELUCIDACION DE NUEVAS LACTONAS MACROCICLICAS DENOMINADAS "COMBRETASTINA D-1" Y "COMBRETASTINA D2", CADA UNA DE LAS CUALES SE HA ENCONTRADO QUE POSEE PROPIEDADES INESPERADAS DE INHIBICION DEL CRECIMIENTO CELULAR. LAS LACTONAS TIENEN LA FORMULA ESTRUCTURAL (I).
ES90304290T 1989-04-26 1990-04-20 Lactonas macrociclicas inhibidoras del crecimiento celular denominadas combretastatina d-2. Expired - Lifetime ES2070276T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/344,005 US4940726A (en) 1989-04-26 1989-04-26 Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2

Publications (1)

Publication Number Publication Date
ES2070276T3 true ES2070276T3 (es) 1995-06-01

Family

ID=23348618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90304290T Expired - Lifetime ES2070276T3 (es) 1989-04-26 1990-04-20 Lactonas macrociclicas inhibidoras del crecimiento celular denominadas combretastatina d-2.

Country Status (8)

Country Link
US (1) US4940726A (es)
EP (1) EP0397336B1 (es)
JP (1) JP2929025B2 (es)
AT (1) ATE120193T1 (es)
CA (1) CA2010886A1 (es)
DE (1) DE69017946T2 (es)
DK (1) DK0397336T3 (es)
ES (1) ES2070276T3 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3919255A1 (de) * 1989-06-13 1990-12-20 Bayer Ag Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
US5393897A (en) * 1993-07-02 1995-02-28 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of spongistatins 5,7,8 and 9
CA2358925C (en) 1999-02-18 2010-04-20 Oxigene, Inc. Compositions and methods for use in targeting vascular destruction
US6703020B1 (en) * 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
US6342219B1 (en) 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
US20050209310A1 (en) * 2000-12-22 2005-09-22 Chaplin David J Methods for modulating tumor growth and metastasis
US7037906B1 (en) * 2000-12-22 2006-05-02 Oxigene, Inc. Methods for modulating tumor growth and metastasis
EP2281578A3 (en) 2002-07-15 2011-04-13 Board of Regents, The University of Texas System Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in treating viral infections and cancer
US20040052868A1 (en) * 2002-09-12 2004-03-18 William Asiedu Composition treating for AIDS and associated conditions
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
EA034136B1 (ru) 2007-11-09 2020-01-09 Перигрин Фармасьютикалз, Инк. Изолированное антитело, которое связывается с vegf, и его применения
JP5302328B2 (ja) 2007-11-21 2013-10-02 オキシジーン， インコーポレイテッド 造血性新生物を治療するための方法
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
WO2016130969A1 (en) 2015-02-13 2016-08-18 George Robert Pettit Silstatin compounds
EP3337495A4 (en) 2015-08-18 2019-04-10 Mateon Therapeutics, Inc. USE OF VDA TO ENHANCE IMMUNOMODULATION THERAPIES AGAINST TUMORS
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2019094709A1 (en) 2017-11-09 2019-05-16 Pettit George R Betulastatin compounds
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708962A (en) * 1984-12-17 1987-11-24 Harbor Branch Oceanographic Institution, Inc. Antiviral and antitumor cyclohexadienone compositions

Also Published As

Publication number Publication date
DE69017946T2 (de) 1995-09-14
EP0397336A2 (en) 1990-11-14
EP0397336A3 (en) 1991-03-27
DK0397336T3 (da) 1995-06-06
EP0397336B1 (en) 1995-03-22
CA2010886A1 (en) 1990-10-26
US4940726A (en) 1990-07-10
JPH02295986A (ja) 1990-12-06
JP2929025B2 (ja) 1999-08-03
DE69017946D1 (de) 1995-04-27
ATE120193T1 (de) 1995-04-15

Similar Documents

Publication Publication Date Title
ES2070276T3 (es) Lactonas macrociclicas inhibidoras del crecimiento celular denominadas combretastatina d-2.
TNSN87033A1 (fr) TOLUNITRILES SUBSTITUES PAR DESα - HETEROCYCLES
ATE233274T1 (de) Oxyiminopregnancarbolactone
DK109487A (da) Fungicid paa basis af et cyanopyrrolderivat
DK0447171T3 (da) Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf
ATE78465T1 (de) Kathartica.
DE69122866T2 (de) Herstellung von substituierten piperidinen
FI844225A0 (fi) Griseolinsyraderivat och deras anvaendning.
FI851261L (fi) Substituerade bensopyraner, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
FR2599752B1 (fr) Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
DE3869692D1 (de) Zellproliferationsinhibitor.
DK471979A (da) Estere af 1,1,2-triphenylalkenderivater
FR2446279A1 (fr) Cis- et trans-3-aryloxy-4-hydroxypyrrolidines et leurs derives, utiles notamment en medecine veterinaire comme antidepresseurs
SE0003795D0 (sv) Pharmaceutically useful compounds
ATE100439T1 (de) 2-(2-hydroxy-3-phenoxypropylamino)-ethoxybenzol derivate.
NO903281L (no) S-substituerte beta-tioakrylamider og anvendelse derav sommikrobiocider.
FI930092A0 (fi) Indanopyrrolidinkarbamater
DE59405727D1 (de) Thiocarbamoylverbindungen als mikrobizide
FR2380272A1 (fr) Derives de la coumarine et d'indane-diode, utilisables comme medicament
DE3580888D1 (de) 2-aminothiazolderivate die eine saeureausscheidungshemmende wirkung besitzen.
FR2366263A1 (fr) Diisocyanates aliphatiques, leur preparation et leur utilisation pour la fabrication de resines de polyurethannes
DK0580624T3 (da) Hidtil ukendte cytarabinderivater, fremstilling og anvendelse deraf
FI904033A0 (fi) Nya 1,3-oxaziner.
SU1681496A1 (ru) Карбизопентоксиметиловый эфир n,n-диэтилдитиокарбаминовой кислоты, обладающий фунгицидными свойствами
FI905922A0 (fi) Antagonister foer a-adrenerga receptorer.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 397336

Country of ref document: ES