DE69017946D1 - Zellwachstum hemmende makrozyklische Lactone namens Combretastatin D-2. - Google Patents
Zellwachstum hemmende makrozyklische Lactone namens Combretastatin D-2.Info
- Publication number
- DE69017946D1 DE69017946D1 DE69017946T DE69017946T DE69017946D1 DE 69017946 D1 DE69017946 D1 DE 69017946D1 DE 69017946 T DE69017946 T DE 69017946T DE 69017946 T DE69017946 T DE 69017946T DE 69017946 D1 DE69017946 D1 DE 69017946D1
- Authority
- DE
- Germany
- Prior art keywords
- combretastatin
- cell growth
- called
- macrocyclic lactones
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002596 lactones Chemical class 0.000 title abstract 3
- QXDPFEIJLOEFJN-UHFFFAOYSA-N Combretastatin D2 Natural products Oc1ccc2CCC(=O)OCC=C/c3cccc(Oc1c2)c3 QXDPFEIJLOEFJN-UHFFFAOYSA-N 0.000 title abstract 2
- 230000010261 cell growth Effects 0.000 title abstract 2
- DTZHRIFDDQELBE-UPHRSURJSA-N combretastatin d-2 Chemical compound O1C(=C2)C(O)=CC=C2CCC(=O)OC\C=C/C2=CC=C1C=C2 DTZHRIFDDQELBE-UPHRSURJSA-N 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- UNKWNXAIWJJVFF-UHFFFAOYSA-N Combretastatin D-1 Natural products Oc1ccc2CCC(=O)OCC3OC3c4cccc(Oc1c2)c4 UNKWNXAIWJJVFF-UHFFFAOYSA-N 0.000 abstract 1
- COGWIGJGNQCZPK-UHFFFAOYSA-N O1C(=C2)C(O)=CC=C2CCC(=O)OCC2OC2C2=CC=C1C=C2 Chemical compound O1C(=C2)C(O)=CC=C2CCC(=O)OCC2OC2C2=CC=C1C=C2 COGWIGJGNQCZPK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Detergent Compositions (AREA)
- Lubricants (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/344,005 US4940726A (en) | 1989-04-26 | 1989-04-26 | Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69017946D1 true DE69017946D1 (de) | 1995-04-27 |
| DE69017946T2 DE69017946T2 (de) | 1995-09-14 |
Family
ID=23348618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69017946T Expired - Lifetime DE69017946T2 (de) | 1989-04-26 | 1990-04-20 | Zellwachstum hemmende makrozyklische Lactone namens Combretastatin D-2. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4940726A (de) |
| EP (1) | EP0397336B1 (de) |
| JP (1) | JP2929025B2 (de) |
| AT (1) | ATE120193T1 (de) |
| CA (1) | CA2010886A1 (de) |
| DE (1) | DE69017946T2 (de) |
| DK (1) | DK0397336T3 (de) |
| ES (1) | ES2070276T3 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3919255A1 (de) * | 1989-06-13 | 1990-12-20 | Bayer Ag | Dibenzo/1,5/dioxocin-5-one-derivate, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US5393897A (en) * | 1993-07-02 | 1995-02-28 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Isolation and structure of spongistatins 5,7,8 and 9 |
| JP2002537262A (ja) | 1999-02-18 | 2002-11-05 | オキシジェン，インコーポレイティド | 血管破壊のターゲッティングに使用するための組成物および方法 |
| EP1185559A2 (de) | 1999-04-28 | 2002-03-13 | Board Of Regents, The University Of Texas System | Zusammensetzungen und verfahren zur krebsbehandlung durch die selektive hemmung von vegf |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| US7037906B1 (en) * | 2000-12-22 | 2006-05-02 | Oxigene, Inc. | Methods for modulating tumor growth and metastasis |
| US20050209310A1 (en) * | 2000-12-22 | 2005-09-22 | Chaplin David J | Methods for modulating tumor growth and metastasis |
| DK1537146T3 (da) | 2002-07-15 | 2011-04-04 | Univ Texas | Antistoffer, der binder til anioniske phospholipider og aminophospholipider, og deres anvendelse til behandling af virusinfektioner |
| US20040052868A1 (en) * | 2002-09-12 | 2004-03-18 | William Asiedu | Composition treating for AIDS and associated conditions |
| US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
| US20090017140A1 (en) * | 2007-07-09 | 2009-01-15 | Peter Koepke | Maytenus abenfolia extract and methods of extracting and using such extract |
| US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
| US7879369B2 (en) * | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| MX2010005104A (es) | 2007-11-09 | 2010-08-04 | Peregrine Pharmaceuticals Inc | Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos. |
| AU2008326251B2 (en) | 2007-11-21 | 2014-03-06 | Mateon Therapeutics, Inc. | Method for treating hematopoietic neoplasms |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| WO2016130969A1 (en) | 2015-02-13 | 2016-08-18 | George Robert Pettit | Silstatin compounds |
| US11419934B2 (en) | 2015-08-18 | 2022-08-23 | Oncotelic Therapeutics, Inc. | Use of VDAS to enhance immunomodulating therapies against tumors |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11629167B2 (en) | 2017-11-09 | 2023-04-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Betulastatin compounds |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708962A (en) * | 1984-12-17 | 1987-11-24 | Harbor Branch Oceanographic Institution, Inc. | Antiviral and antitumor cyclohexadienone compositions |
-
1989
- 1989-04-26 US US07/344,005 patent/US4940726A/en not_active Expired - Lifetime
-
1990
- 1990-02-26 CA CA002010886A patent/CA2010886A1/en not_active Abandoned
- 1990-03-19 JP JP2067412A patent/JP2929025B2/ja not_active Expired - Fee Related
- 1990-04-20 DK DK90304290.1T patent/DK0397336T3/da active
- 1990-04-20 ES ES90304290T patent/ES2070276T3/es not_active Expired - Lifetime
- 1990-04-20 EP EP90304290A patent/EP0397336B1/de not_active Expired - Lifetime
- 1990-04-20 DE DE69017946T patent/DE69017946T2/de not_active Expired - Lifetime
- 1990-04-20 AT AT90304290T patent/ATE120193T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02295986A (ja) | 1990-12-06 |
| DK0397336T3 (da) | 1995-06-06 |
| ES2070276T3 (es) | 1995-06-01 |
| EP0397336B1 (de) | 1995-03-22 |
| EP0397336A2 (de) | 1990-11-14 |
| CA2010886A1 (en) | 1990-10-26 |
| DE69017946T2 (de) | 1995-09-14 |
| ATE120193T1 (de) | 1995-04-15 |
| JP2929025B2 (ja) | 1999-08-03 |
| US4940726A (en) | 1990-07-10 |
| EP0397336A3 (de) | 1991-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |