ES2070258T5 - Procedimiento de desbromacion de 2-sustituido-5-bromo-6-metoxinaftalenos. - Google Patents
Procedimiento de desbromacion de 2-sustituido-5-bromo-6-metoxinaftalenos.Info
- Publication number
- ES2070258T5 ES2070258T5 ES90123978T ES90123978T ES2070258T5 ES 2070258 T5 ES2070258 T5 ES 2070258T5 ES 90123978 T ES90123978 T ES 90123978T ES 90123978 T ES90123978 T ES 90123978T ES 2070258 T5 ES2070258 T5 ES 2070258T5
- Authority
- ES
- Spain
- Prior art keywords
- sub
- metoxinaftalenos
- debromation
- bromo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000000370 acceptor Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SON NAFTALENOS DE FORMULA EN DONDE X REPRESENTA COCH SUB 3, COC SUB 2H SUB 5, CH(CH SUB 3)COOH, CH(CH SUB 3)COOR, CH(CH SUB 3)CN Y CH(CH SUB 3)CONHR SUB 1, R REPRESENTA UN ALKILO Y R SUB 1 UN HIDROGENO, ALKILO O HIDROXIALKILO, ESTOS SON DESBROMINADOS POR MEDIO DE ACEPTORES DE BROMO, COMO LOS ALKILARENOS Y ALKOXIARENOS, EN PRESENCIA DE ACIDOS DE LEWIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT01929990A IT1238008B (it) | 1990-02-08 | 1990-02-08 | Procedimento per la debromurazione di 2-sostituiti-5-bromo- 6-metossinaftaleni |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2070258T3 ES2070258T3 (es) | 1995-06-01 |
ES2070258T5 true ES2070258T5 (es) | 2002-02-01 |
Family
ID=11156536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90123978T Expired - Lifetime ES2070258T5 (es) | 1990-02-08 | 1990-12-12 | Procedimiento de desbromacion de 2-sustituido-5-bromo-6-metoxinaftalenos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5107013A (es) |
EP (1) | EP0440930B2 (es) |
AT (1) | ATE120172T1 (es) |
DE (1) | DE69018058T3 (es) |
DK (1) | DK0440930T3 (es) |
ES (1) | ES2070258T5 (es) |
GR (1) | GR3015528T3 (es) |
IT (1) | IT1238008B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4318069C1 (de) * | 1993-06-01 | 1994-03-31 | Cassella Ag | Verfahren zur Herstellung von 5-Brom-6-methoxy-1-naphthoesäuremethylester |
IT1285567B1 (it) | 1996-02-21 | 1998-06-18 | Alfa Chem Ital | Nuovo processo per la sintesi del nabumetone |
CN110183323A (zh) * | 2019-07-09 | 2019-08-30 | 重庆医药高等专科学校 | D,l-体萘普生的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1168387B (it) * | 1981-04-01 | 1987-05-20 | Alfa Farmaceutici Spa | Procedimento per la preparazione dell'acido 2-(6-metossi-2-naftil)-propionico |
IT1190362B (it) * | 1985-05-30 | 1988-02-16 | Zambon Spa | Preparazione del (6-metossi-2-naftil)-(1-bormoetil)-chetone e dei suoi derivati |
-
1990
- 1990-02-08 IT IT01929990A patent/IT1238008B/it active IP Right Grant
- 1990-12-12 EP EP90123978A patent/EP0440930B2/en not_active Expired - Lifetime
- 1990-12-12 AT AT90123978T patent/ATE120172T1/de not_active IP Right Cessation
- 1990-12-12 DK DK90123978.0T patent/DK0440930T3/da active
- 1990-12-12 DE DE69018058T patent/DE69018058T3/de not_active Expired - Fee Related
- 1990-12-12 ES ES90123978T patent/ES2070258T5/es not_active Expired - Lifetime
- 1990-12-27 US US07/634,742 patent/US5107013A/en not_active Expired - Lifetime
-
1995
- 1995-03-23 GR GR940402780T patent/GR3015528T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69018058D1 (de) | 1995-04-27 |
GR3015528T3 (en) | 1995-06-30 |
EP0440930B1 (en) | 1995-03-22 |
ATE120172T1 (de) | 1995-04-15 |
DE69018058T3 (de) | 2002-04-18 |
EP0440930A2 (en) | 1991-08-14 |
EP0440930A3 (en) | 1992-04-08 |
DE69018058T2 (de) | 1995-09-28 |
IT9019299A1 (it) | 1991-08-09 |
IT1238008B (it) | 1993-06-21 |
DK0440930T3 (da) | 1995-04-10 |
EP0440930B2 (en) | 2001-09-12 |
IT9019299A0 (it) | 1990-02-08 |
ES2070258T3 (es) | 1995-06-01 |
US5107013A (en) | 1992-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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