ES2069219T3 - Formulacion adhesiva para mejorar la regeneracion de nervios lesionados y formulacion farmaceutica adhesiva correspondiente. - Google Patents
Formulacion adhesiva para mejorar la regeneracion de nervios lesionados y formulacion farmaceutica adhesiva correspondiente.Info
- Publication number
- ES2069219T3 ES2069219T3 ES91309137T ES91309137T ES2069219T3 ES 2069219 T3 ES2069219 T3 ES 2069219T3 ES 91309137 T ES91309137 T ES 91309137T ES 91309137 T ES91309137 T ES 91309137T ES 2069219 T3 ES2069219 T3 ES 2069219T3
- Authority
- ES
- Spain
- Prior art keywords
- adhesive
- nerve
- regeneration
- formulation
- improve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA REGENERACION DE NERVIOS HERIDOS SE MEJORA SUMINISTRANDO COLAGENASA A LA ZONA DAÑADA DEL NERVIO. EL CRECIMIENTO DEL NERVIO EN LA ZONA DAÑADA ES AYUDADO POR LA PRESENCIA DE CANTIDADES EFECTIVAS DE COLAGENASA DURANTE EL PROCESO DE REGENERACION. SI EL NERVIO HA SIDO SECCIONADO, LA COLAGENASA SE SUMINISTRA A LOS EXTREMOS DE AMBAS PARTES DEL NERVIO. UN NERVIO INJERTADO PUEDE INTERPONERSE ENTRE LAS DOS ZONAS SECCIONADAS. LA FIBRINA NATURAL YA HA SIDO USADA PARA UNIR NERVIOS SECCIONADOS, ENCONTRANDOSE QUE LA COLAGENASA ES EFECTIVA CUANDO SE USA MEZCLADA CON FIBRINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/593,778 US5173295A (en) | 1990-10-05 | 1990-10-05 | Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2069219T3 true ES2069219T3 (es) | 1995-05-01 |
Family
ID=24376136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91309137T Expired - Lifetime ES2069219T3 (es) | 1990-10-05 | 1991-10-04 | Formulacion adhesiva para mejorar la regeneracion de nervios lesionados y formulacion farmaceutica adhesiva correspondiente. |
Country Status (4)
Country | Link |
---|---|
US (2) | US5173295A (es) |
EP (1) | EP0479615B1 (es) |
DE (1) | DE69107946T2 (es) |
ES (1) | ES2069219T3 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5219895A (en) * | 1991-01-29 | 1993-06-15 | Autogenesis Technologies, Inc. | Collagen-based adhesives and sealants and methods of preparation and use thereof |
US5393792A (en) * | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
US5552452A (en) * | 1993-03-15 | 1996-09-03 | Arch Development Corp. | Organic tissue glue for closure of wounds |
WO1996000283A1 (en) * | 1994-06-24 | 1996-01-04 | Boehringer Mannheim Corporation | A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum |
US5589171A (en) * | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
US5585007A (en) | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
AU697045B2 (en) * | 1995-01-16 | 1998-09-24 | Baxter International Inc. | Self-supporting sheet-like material of cross-linked fibrin for preventing post- operative adhesions |
US5851522A (en) * | 1995-06-07 | 1998-12-22 | Trustees Of Tufts College | Enhancing keratinocyte migration |
FR2723696A1 (fr) * | 1995-08-18 | 1996-02-23 | Advande Biofactures Of Curacao | Utilisation de collagenase dans une preparation pharmaceutique pour le traitement de la maladie de dupuytren |
US5989888A (en) * | 1996-01-24 | 1999-11-23 | Roche Diagnostics Corporation | Purified mixture of collagenase I, collagenase II and two other proteases |
EP0917444A1 (en) | 1996-07-12 | 1999-05-26 | Baxter Travenol Laboratories, Inc. | A fibrin delivery device and method for forming fibrin on a surface |
US5830741A (en) * | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
US6183498B1 (en) | 1999-09-20 | 2001-02-06 | Devore Dale P. | Methods and products for sealing a fluid leak in a tissue |
IL160188A0 (en) * | 2001-08-13 | 2004-07-25 | Univ Florida | Materials and methods to promote repair of nerve tissue |
US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7544171B2 (en) * | 2004-10-22 | 2009-06-09 | General Patent Llc | Methods for promoting nerve regeneration and neuronal growth and elongation |
US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
EP1848472B1 (en) | 2005-02-07 | 2015-04-01 | Hanuman LLC | Platelet rich plasma concentrate apparatus and method |
US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
US7988648B2 (en) * | 2005-03-04 | 2011-08-02 | General Patent, Llc | Pancreas regeneration treatment for diabetics using extracorporeal acoustic shock waves |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8430813B2 (en) * | 2006-05-26 | 2013-04-30 | Depuy Spine, Inc. | Illuminated surgical access system including a surgical access device and integrated light emitter |
US8323642B2 (en) | 2006-12-13 | 2012-12-04 | Depuy Mitek, Inc. | Tissue fusion method using collagenase for repair of soft tissue |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
WO2014066622A2 (en) | 2012-10-24 | 2014-05-01 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US20150141786A1 (en) * | 2013-11-15 | 2015-05-21 | Case Western Reserve University | Interfacing With The Peripheral Nervous System (PNS) Using Targeted Fascicular Interface Device |
US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
EP3288626A4 (en) | 2015-04-27 | 2019-01-23 | Reflex Medical Inc. | SYSTEMS AND METHODS FOR SYMPATHETIC CARDIO-PULMONARY NEUROMODULATION |
US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
US11246879B2 (en) | 2016-02-09 | 2022-02-15 | Tulai Therapeutics, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
US11389371B2 (en) | 2018-05-21 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods |
US11389373B2 (en) | 2016-04-18 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods to prevent or treat opioid addiction |
US11458069B2 (en) | 2016-04-18 | 2022-10-04 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods to treat medical conditions using reflexology zones |
US11389372B2 (en) | 2016-04-18 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods |
US11389370B2 (en) | 2016-04-18 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Treatments for blood sugar levels and muscle tissue optimization using extracorporeal acoustic shock waves |
CA3031761A1 (en) | 2016-06-29 | 2018-01-04 | Tulavi Therapeutics, Inc. | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
CN117599244A (zh) | 2018-07-02 | 2024-02-27 | 图拉维治疗股份有限公司 | 原位形成神经帽的方法和装置 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3705083A (en) * | 1966-07-08 | 1972-12-05 | Agricultural Biolog Corp | Process for producing collagenase |
ES367241A1 (es) * | 1968-05-15 | 1971-07-16 | Worthington Biochem Corp | Metodo de preparar colagenasa purificada que esta esencial-mente exenta de actividad proteolitica y elastolitica. |
US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
US4645668A (en) * | 1983-08-04 | 1987-02-24 | Biospecifics, Nv | Method for the prevention and treatment of scars with enzymes |
US4983393A (en) * | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
US5045601A (en) * | 1989-06-13 | 1991-09-03 | Biointerface Technologies, Inc. | Pressure-sensitive adhesive compositions suitable for medical uses |
-
1990
- 1990-10-05 US US07/593,778 patent/US5173295A/en not_active Expired - Fee Related
-
1991
- 1991-10-04 EP EP91309137A patent/EP0479615B1/en not_active Expired - Lifetime
- 1991-10-04 DE DE69107946T patent/DE69107946T2/de not_active Expired - Fee Related
- 1991-10-04 ES ES91309137T patent/ES2069219T3/es not_active Expired - Lifetime
-
1992
- 1992-09-08 US US07/941,570 patent/US5279825A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69107946T2 (de) | 1995-07-13 |
EP0479615A1 (en) | 1992-04-08 |
DE69107946D1 (de) | 1995-04-13 |
EP0479615B1 (en) | 1995-03-08 |
US5279825A (en) | 1994-01-18 |
US5173295A (en) | 1992-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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