ES2065526T3 - Filtro giratorio para eliminar medio de cultivo substancialmente libre de celulas de un sistema de cultivo de celulas en suspension. - Google Patents

Filtro giratorio para eliminar medio de cultivo substancialmente libre de celulas de un sistema de cultivo de celulas en suspension.

Info

Publication number
ES2065526T3
ES2065526T3 ES90905995T ES90905995T ES2065526T3 ES 2065526 T3 ES2065526 T3 ES 2065526T3 ES 90905995 T ES90905995 T ES 90905995T ES 90905995 T ES90905995 T ES 90905995T ES 2065526 T3 ES2065526 T3 ES 2065526T3
Authority
ES
Spain
Prior art keywords
filter
remove substantially
rotating filter
cultivation
revolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905995T
Other languages
English (en)
Inventor
Roland Varecka
Rudolf F Bliem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of ES2065526T3 publication Critical patent/ES2065526T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation

Landscapes

  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN FILTRO DE REVOLUCION PARA ELIMINAR SUSTANCIALMENTE CELULAS LIBRES DE UN MEDIO DE UNA SUSPENSION AGITADA EN UNA VASIJA DE CULTIVO, EN DONDE UN TAMPON ESTACIONARIO ESTA DISPUESTO EN EL ESPACIO INTERIOR DEL FILTRO DE REVOLUCION PARA ROMPER EL FLUJO DEL LIQUIDO EN EL Y MINIMIZAR LA TENDENCIA DE LAS CELULAS PARA ACUMULARSE SOBRE Y ENSUCIAR LAS SUPERFICIES DE LAS CARAS INTERNAS DEL FILTRO, TENIENDO LA SUPERFICIE DEL FILTRO UN TAMAÑO PARA EXCLUIR SUSTANCIALMENTE MATERIALES MAYORES DE ALREDEDOR DE 8 A 10 MICRAS, Y SIENDO EL FILTRO DE REVOLUCION ROTATORIO CON INDEPENDENCIA DE, Y EN DIRECCION DE ROTACION OPUESTA AL, DISPOSITIVO DE LLENADO DE LA VASIJA.
ES90905995T 1989-03-17 1990-03-15 Filtro giratorio para eliminar medio de cultivo substancialmente libre de celulas de un sistema de cultivo de celulas en suspension. Expired - Lifetime ES2065526T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/325,286 US5019512A (en) 1989-03-17 1989-03-17 Spin filter for removing substantially cell-free culture medium from suspension cell culture system

Publications (1)

Publication Number Publication Date
ES2065526T3 true ES2065526T3 (es) 1995-02-16

Family

ID=23267235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905995T Expired - Lifetime ES2065526T3 (es) 1989-03-17 1990-03-15 Filtro giratorio para eliminar medio de cultivo substancialmente libre de celulas de un sistema de cultivo de celulas en suspension.

Country Status (9)

Country Link
US (1) US5019512A (es)
EP (1) EP0414887B1 (es)
JP (1) JP3030516B2 (es)
AT (1) ATE111515T1 (es)
CA (1) CA2012321C (es)
DE (1) DE69012489T2 (es)
DK (1) DK0414887T3 (es)
ES (1) ES2065526T3 (es)
WO (1) WO1990011345A1 (es)

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US5240606A (en) * 1990-07-09 1993-08-31 Cytyc Corporation Apparatus for preparing cells for examination
US5269918A (en) * 1990-07-09 1993-12-14 Cytyc Corporation Clinical cartridge apparatus
US5143627A (en) * 1990-07-09 1992-09-01 Cytyc Corporation Method and apparatus for preparing cells for examination
US5282978A (en) * 1990-07-09 1994-02-01 Cytyc Corporation Specimen processor method and apparatus
US5126269A (en) * 1990-09-13 1992-06-30 Life Techologies, Inc. Spin filter perfusion bioreactor (sfpb) cell culture apparatus
AT394576B (de) * 1991-01-16 1992-05-11 Vogelbusch Gmbh Reaktor zur durchfuehrung biologischer reaktionen mittels biokatalysatoren
US5246671A (en) * 1991-04-15 1993-09-21 The United States Of America As Represented By The Secretary Of The Army Reactor
WO1994017178A1 (en) * 1993-01-29 1994-08-04 New Brunswick Scientific Co., Inc. Method and apparatus for anchorage and suspension cell culture
DE19918409A1 (de) * 1999-04-22 2000-10-26 Forschungszentrum Juelich Gmbh Bioreaktor umfassend einen Medienablauf und einen Rührer sowie Rührer und Medienablauf
US20030104494A1 (en) * 2001-10-26 2003-06-05 Ilya Ravkin Assay systems with adjustable fluid communication
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
US20040124140A1 (en) * 2002-12-30 2004-07-01 Sawyer Gary A. In situ filtration draught tube reactor system
US20040259240A1 (en) * 2003-06-17 2004-12-23 Fadden Stephen J. Method and apparatus for filtration of bioreactor recombinant proteins
AU2004286351A1 (en) * 2003-11-03 2005-05-12 Centocor, Inc. Method for maintaining low shear in a bioprocessing system
JP2007525984A (ja) * 2004-03-05 2007-09-13 ディーエスエム アイピー アセッツ ビー．ブイ． 連続的灌流および交互接線流による細胞培養の方法
KR101685246B1 (ko) 2006-07-14 2016-12-09 디피엑스 홀딩스 비.브이. 개선된 세포 배양 방법
KR100834110B1 (ko) * 2007-01-25 2008-06-02 한국과학기술원 상류 충전탑 세포재순환 장치가 장착된 다단계 ｃｓｔｒ생물반응기 시스템
CN101085978B (zh) * 2007-06-27 2011-01-05 广州铭康生物工程有限公司 一种用于动物细胞灌流培养的过滤-沉降双结合灌流系统
KR100893875B1 (ko) 2007-09-11 2009-04-20 박중진 여과통 회전 탈수식 배양기
US20100112696A1 (en) * 2008-11-03 2010-05-06 Baxter International Inc. Apparatus And Methods For Processing Tissue To Release Cells
US8309343B2 (en) 2008-12-01 2012-11-13 Baxter International Inc. Apparatus and method for processing biological material
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
US20110117538A1 (en) * 2009-11-13 2011-05-19 Niazi Sarfaraz K Bioreactors for fermentation and related methods
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
CN103649298A (zh) 2011-05-12 2014-03-19 精密科学公司 核酸的分离
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
WO2012170232A1 (en) 2011-06-09 2012-12-13 Bellbrook Labs, Llc Device for washing suspended cells or particles
DK3049521T3 (en) 2013-09-25 2019-04-23 Univ Cornell Compounds for inducing antitumor immunity and methods thereof
WO2016061526A1 (en) 2014-10-17 2016-04-21 Sani-Tech West, Inc. Mixing and filtering system and method
JP6744161B2 (ja) * 2016-07-19 2020-08-19 株式会社日立プラントサービス 分離装置、培養装置および分離方法
KR101956304B1 (ko) * 2016-09-06 2019-03-11 한국화학연구원 세포 배양 용기
US10858607B2 (en) * 2017-05-18 2020-12-08 Active Energy Group Plc Process for beneficiating and cleaning biomass
WO2019147310A2 (en) 2017-08-31 2019-08-01 Massachusetts Institute Of Technology Filtration systems and methods for manufacturing biologically-produced products
CN112322458B (zh) * 2020-11-07 2022-03-11 河南农业大学 一种提振式生物质厌氧装置
JP2022093036A (ja) * 2020-12-11 2022-06-23 株式会社神鋼環境ソリューション ろ過装置
CA3200169A1 (en) * 2021-01-21 2022-07-28 Luis Haupt Method of changing culture medium of a culture using spinfilters

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US3186917A (en) * 1962-04-18 1965-06-01 Biochemical Processes Inc Process and apparatus for dialysis fermentation
CH647547A5 (de) * 1982-02-12 1985-01-31 Chemap Ag Verfahren und vorrichtung zum zuechten von mikroorganismen.
FR2527799B1 (fr) * 1982-05-28 1986-05-23 Thomson Csf Dispositif de mise en memoire d'une image coherente dans une cavite optique multimode
DE3402697A1 (de) * 1984-01-26 1985-08-01 Bayer Ag, 5090 Leverkusen Verwendung von hydrophilen, hochgefuellten polyurethanmassen zur biologischen abwasserreinigung
US4649118A (en) * 1984-04-05 1987-03-10 The Virtis Company, Inc. Cell culturing apparatus with improved stirring and filter means
JPS60259179A (ja) * 1984-06-05 1985-12-21 Teijin Ltd 細胞培養槽及び細胞培養方法
SU1296575A1 (ru) * 1984-12-10 1987-03-15 Предприятие П/Я Р-6729 Аппарат дл культивировани клеток
JPS62265A (ja) * 1985-02-05 1987-01-06 Teijin Ltd 細胞培養装置および方法
US4639422A (en) * 1986-02-03 1987-01-27 Monsanto Company Cell culture filter apparatus and method
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
US4988623A (en) * 1988-06-30 1991-01-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotating bio-reactor cell culture apparatus

Also Published As

Publication number Publication date
WO1990011345A1 (en) 1990-10-04
JPH03505041A (ja) 1991-11-07
DK0414887T3 (da) 1994-11-14
JP3030516B2 (ja) 2000-04-10
CA2012321C (en) 2004-05-18
CA2012321A1 (en) 1990-09-17
EP0414887A4 (en) 1991-09-11
DE69012489D1 (de) 1994-10-20
EP0414887B1 (en) 1994-09-14
ATE111515T1 (de) 1994-09-15
EP0414887A1 (en) 1991-03-06
DE69012489T2 (de) 1995-02-02
US5019512A (en) 1991-05-28

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