ES2065040T3 - Compuestos de partida para la preparacion de 10-g(b)-h-esteroides y un procedimiento para la preparacion de estos compuestos de partida. - Google Patents

Compuestos de partida para la preparacion de 10-g(b)-h-esteroides y un procedimiento para la preparacion de estos compuestos de partida.

Info

Publication number
ES2065040T3
ES2065040T3 ES91910278T ES91910278T ES2065040T3 ES 2065040 T3 ES2065040 T3 ES 2065040T3 ES 91910278 T ES91910278 T ES 91910278T ES 91910278 T ES91910278 T ES 91910278T ES 2065040 T3 ES2065040 T3 ES 2065040T3
Authority
ES
Spain
Prior art keywords
preparation
starting compounds
compounds
pct
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910278T
Other languages
English (en)
Inventor
Eckhard Ottow
Gunter Neef
Arwed Cleve
Rudolf Wiechert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2065040T3 publication Critical patent/ES2065040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE LA FORMULA GENERAL (III), EN DONDE A Y B EQUIVALEN CONJUNTAMENTE A UN ENLACE ADICIONAL Y D A UN ATOMO DE HIDROGENO, O B Y A CONJUNTAMENTE A UN ENLACE ADICIONAL Y A A UN ATOMO DE HIDROGENO, E Y Y'' A GRUPOS CETONICOS PROTEGIDOS ASI COMO R1 Y R4 TIENEN EL SIGNIFICADO INDICADO EN LA DESCRIPCION, ASI COMO UN PROCEDIMIENTO PARA SU PRODUCCION. LOS NUEVOS COMPUESTOS SON PRODUCTOS INICIALES VALIOSOS PARA LA PRODUCCION DE LOS COMPUESTOS ALTAMENTE EFECTIVOS ANTIGESTAGENOS DE LA FORMULA GENERAL (I), EN DONDE X, R1, R2, R3 Y R4 TIENEN EL SIGNIFICADO INDICADO EN LA DESCRIPCION.
ES91910278T 1990-06-01 1991-06-03 Compuestos de partida para la preparacion de 10-g(b)-h-esteroides y un procedimiento para la preparacion de estos compuestos de partida. Expired - Lifetime ES2065040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4018168A DE4018168A1 (de) 1990-06-01 1990-06-01 Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen

Publications (1)

Publication Number Publication Date
ES2065040T3 true ES2065040T3 (es) 1995-02-01

Family

ID=6407913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910278T Expired - Lifetime ES2065040T3 (es) 1990-06-01 1991-06-03 Compuestos de partida para la preparacion de 10-g(b)-h-esteroides y un procedimiento para la preparacion de estos compuestos de partida.

Country Status (12)

Country Link
US (1) US5359054A (es)
EP (1) EP0532565B1 (es)
JP (1) JP2999257B2 (es)
AT (1) ATE114318T1 (es)
CA (1) CA2084314C (es)
DE (2) DE4018168A1 (es)
DK (1) DK0532565T3 (es)
ES (1) ES2065040T3 (es)
FI (1) FI111643B (es)
HU (1) HU221728B1 (es)
NO (1) NO304116B1 (es)
WO (1) WO1991018917A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4042007A1 (de) * 1990-12-22 1992-06-25 Schering Ag 6,7-modifizierte-11(beta)-aryl-4-estrene
US5939545A (en) * 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
DE19610667C2 (de) * 1996-03-08 1998-04-09 Schering Ag (Z)-11ß-[4-(Dimethylamino)phenyl]17ß-hydroxy-17alpha-(3-hydroxy-1-propenyl)estr-4-en-3-on als kristallines Ansolvat
JP2008532725A (ja) 2005-03-21 2008-08-21 チャン，フー デジタル制御され、使用者がプログラム可能且つフィールドで再設置可能な卓球ロボット

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament
US4102907A (en) * 1977-03-07 1978-07-25 The Upjohn Company Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US5182381A (en) * 1982-03-01 1993-01-26 Roussel Ulcaf Intermediates for 3-keto-19-nor-Δ4,9 -steroids
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3786174T2 (de) * 1987-10-13 1993-10-21 Nicholas S Bodor Weiche steroide mit anti-entzündungswirkung.
ES2053714T3 (es) * 1987-12-12 1994-08-01 Akzo Nv Proceso para la preparacion de 11-arilesteroides.
DE3822770A1 (de) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.

Also Published As

Publication number Publication date
HUT62597A (en) 1993-05-28
DE4018168A1 (de) 1991-12-05
HU9203776D0 (en) 1993-03-29
JPH05506445A (ja) 1993-09-22
WO1991018917A1 (de) 1991-12-12
NO924618D0 (no) 1992-11-30
NO304116B1 (no) 1998-10-26
EP0532565B1 (de) 1994-11-23
DE59103593D1 (de) 1995-01-12
ATE114318T1 (de) 1994-12-15
CA2084314A1 (en) 1991-12-02
FI111643B (fi) 2003-08-29
NO924618L (no) 1992-11-30
CA2084314C (en) 2002-12-10
FI925444A (fi) 1992-11-30
HU221728B1 (hu) 2002-12-28
FI925444A0 (fi) 1992-11-30
EP0532565A1 (de) 1993-03-24
US5359054A (en) 1994-10-25
JP2999257B2 (ja) 2000-01-17
DK0532565T3 (da) 1995-05-01

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