ES2063874T3 - Procedimiento para el plegamiento correcto biocatalitico de cadenas de proteinas de fusion recombinantes desnaturalizadas. - Google Patents

Procedimiento para el plegamiento correcto biocatalitico de cadenas de proteinas de fusion recombinantes desnaturalizadas.

Info

Publication number
ES2063874T3
ES2063874T3 ES90115004T ES90115004T ES2063874T3 ES 2063874 T3 ES2063874 T3 ES 2063874T3 ES 90115004 T ES90115004 T ES 90115004T ES 90115004 T ES90115004 T ES 90115004T ES 2063874 T3 ES2063874 T3 ES 2063874T3
Authority
ES
Spain
Prior art keywords
fusion proteins
denaturalized
chains
procedure
folding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115004T
Other languages
English (en)
Inventor
Walter Prof Dr Dr Neupert
Franz-Ulrich Dr Hartl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2063874T3 publication Critical patent/ES2063874T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCEDIMIENTO QUE SE UTILIZA PARA DOBLAR CADENAS CORRECTORAS Y BIOCATALITICAS, DE PROTEINAS DE FUSION RECOMBINADAS Y DESNATURALIZADAS Y CONSISTE EN DOBLAR CORRECTAMENTE PROTEINAS DE FUSION RECOMBINADAS Y DESNATURALIZADAS, A PARTIR DE ATP Y EN PRESENCIA DE PROTEINAS DE CHOQUE DE CALOR, QUE ACTUAN SEGUN EL PRINCIPIO DE BASTERIAS GROEL O EQUIVALENTE DE COMPONENTE HSP60 MITOCONDRIALES Y DESDOBLAR LA SECUENCIA HGUESPED DE ATP, PARA OBTENER UNAS PROTEINAS CONFORMADAS CORRECTAMENTE Y DE APLICACION BIOLOGICA Y MEDICA.
ES90115004T 1989-08-08 1990-08-04 Procedimiento para el plegamiento correcto biocatalitico de cadenas de proteinas de fusion recombinantes desnaturalizadas. Expired - Lifetime ES2063874T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3926103A DE3926103A1 (de) 1989-08-08 1989-08-08 Verfahren zur biokatalytischen korrekten kettenfaltung denaturierter rekombinanter fusionsproteine

Publications (1)

Publication Number Publication Date
ES2063874T3 true ES2063874T3 (es) 1995-01-16

Family

ID=6386675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115004T Expired - Lifetime ES2063874T3 (es) 1989-08-08 1990-08-04 Procedimiento para el plegamiento correcto biocatalitico de cadenas de proteinas de fusion recombinantes desnaturalizadas.

Country Status (9)

Country Link
US (1) US5302518A (es)
EP (1) EP0412465B1 (es)
JP (1) JP3070935B2 (es)
AT (1) ATE112286T1 (es)
DE (2) DE3926103A1 (es)
DK (1) DK0412465T3 (es)
ES (1) ES2063874T3 (es)
IE (1) IE64771B1 (es)
PT (1) PT94934B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4201181A1 (de) * 1992-01-17 1993-07-22 Boehringer Mannheim Gmbh Verfahren zur stabilisierung von proteinen
FR2694571B1 (fr) * 1992-08-10 1994-11-04 Rhone Poulenc Chimie Polypeptides possédant une activité nitrilase, séquence d'ADN codant pour lesdits polypeptides, cassettes d'expression et micro-organismes hôtes permettant leur obtention.
JPH0748398A (ja) * 1993-08-03 1995-02-21 Nippon Oil Co Ltd 変性蛋白質の再生方法及び変性蛋白質再生剤
US5856090A (en) * 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
US6495360B1 (en) 1999-05-28 2002-12-17 Photogen, Inc. Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
GB9913437D0 (en) * 1999-06-09 1999-08-11 Medical Res Council Fusion proteins
US6677139B1 (en) * 1999-12-23 2004-01-13 Genecor International, Inc. Methods for production of proteins in host cells
JP4786303B2 (ja) * 2005-11-02 2011-10-05 三洋化成工業株式会社 タンパク質のリフォールディング剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873312A (en) * 1985-04-25 1989-10-10 Amgen Method for purifying interferon and composition of matter produced thereby

Also Published As

Publication number Publication date
JPH03101700A (ja) 1991-04-26
EP0412465A1 (de) 1991-02-13
US5302518A (en) 1994-04-12
EP0412465B1 (de) 1994-09-28
PT94934B (pt) 1997-05-28
JP3070935B2 (ja) 2000-07-31
DK0412465T3 (da) 1995-02-13
DE3926103C2 (es) 1992-01-23
DE3926103A1 (de) 1991-02-14
DE59007324D1 (de) 1994-11-03
IE902851A1 (en) 1991-02-27
IE64771B1 (en) 1995-09-06
PT94934A (pt) 1991-04-18
ATE112286T1 (de) 1994-10-15

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