ES2063219T3 - CYCLE AMINO ACIDS EXEMPT FROM LACTAMA. - Google Patents
CYCLE AMINO ACIDS EXEMPT FROM LACTAMA.Info
- Publication number
- ES2063219T3 ES2063219T3 ES90116265T ES90116265T ES2063219T3 ES 2063219 T3 ES2063219 T3 ES 2063219T3 ES 90116265 T ES90116265 T ES 90116265T ES 90116265 T ES90116265 T ES 90116265T ES 2063219 T3 ES2063219 T3 ES 2063219T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acids
- lactama
- exempt
- cycle amino
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Abstract
Cyclic amino acids of the general formula VII <IMAGE> in which n denotes the numbers 4 to 6 and pharmaceutical preparations containing them, which are characterised in that, relative to the amino acids VII, they have a content of lactam of the general formula VIII <IMAGE> in which n has the abovementioned meaning, of less than 0.5 % by weight.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3928183A DE3928183A1 (en) | 1989-08-25 | 1989-08-25 | LACTAM-FREE CYCLIC AMINO ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063219T3 true ES2063219T3 (en) | 1995-01-01 |
Family
ID=6387901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90116265T Expired - Lifetime ES2063219T3 (en) | 1989-08-25 | 1990-08-24 | CYCLE AMINO ACIDS EXEMPT FROM LACTAMA. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6054482A (en) |
EP (1) | EP0414263B1 (en) |
JP (2) | JP3148223B2 (en) |
AT (1) | ATE113272T1 (en) |
DE (2) | DE3928183A1 (en) |
DK (1) | DK0414263T3 (en) |
ES (1) | ES2063219T3 (en) |
HK (1) | HK1003480A1 (en) |
IE (1) | IE65291B1 (en) |
MY (1) | MY107056A (en) |
PT (1) | PT95082B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2206078A1 (en) * | 2000-10-23 | 2004-05-01 | Zambon Group S.P.A. | Process for the preparation of gabapentin |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE207878T1 (en) * | 1996-03-14 | 2001-11-15 | Warner Lambert Co | CYCLIC AMINO ACID AS PHARMACEUTICAL ACTIVE INGREDIENTS |
SI0934061T1 (en) | 1996-07-24 | 2003-10-31 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
EP0977772A1 (en) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
JP2002514214A (en) | 1997-04-14 | 2002-05-14 | シーオーアール セラピューティクス インコーポレイテッド | Selective factor Xa inhibitor |
WO1998046591A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
AU9318398A (en) | 1997-10-07 | 1999-04-27 | Warner-Lambert Company | Process for preparing a cyclic amino acid anticonvulsant compound |
US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
DE19751062A1 (en) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | 4-substituted 2-pyrrolidinone derivatives to reduce extracellular glutamate levels |
WO1999059572A1 (en) * | 1998-05-15 | 1999-11-25 | Warner-Lambert Company | Gamma-aminobutyric acid derivatives containing, solid compositions and process for preparing the same |
EP1077692B1 (en) * | 1998-05-15 | 2004-07-28 | Warner-Lambert Company LLC | Amino acid stabilized gabapentin and pregabalin preparations and process for preparing the same |
HU225502B1 (en) * | 1998-12-29 | 2007-01-29 | Richter Gedeon Vegyeszet | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
US6294198B1 (en) | 1999-08-24 | 2001-09-25 | Purepac Pharmaceutical Co. | Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same |
AU2001266992B8 (en) * | 2000-06-16 | 2005-12-01 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin having pH within a controlled range |
EP1289364B1 (en) | 2000-06-16 | 2003-12-10 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin containing more than 2o ppm of chlorine ion |
EP1384473A1 (en) * | 2000-06-16 | 2004-01-28 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin containing more than 20 ppm of chlorine ion |
US7056951B2 (en) * | 2000-09-26 | 2006-06-06 | Mutual Pharmaceutical Co., Inc. | Stable solid dosage forms of amino acids and processes for producing same |
EP1334732B1 (en) * | 2000-11-17 | 2010-06-02 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation of n-[2-(1,6,7,8-tetrahydro-2h-indeno[5,4 b]furan-8-yl)ethyl]propionamide coated with a copolyvidone-containing coating free of polyethylene glycol |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
US7186855B2 (en) * | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
HUP0400183A2 (en) * | 2001-06-11 | 2004-07-28 | Xenoport Inc. | Orally administered dosage forms of gaba analog prodrugs having reduced toxicity |
US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8354438B2 (en) * | 2001-08-08 | 2013-01-15 | Michael Chez | Neurological functions |
US20060159743A1 (en) * | 2001-10-25 | 2006-07-20 | Depomed, Inc. | Methods of treating non-nociceptive pain states with gastric retentive gabapentin |
US20070184104A1 (en) * | 2001-10-25 | 2007-08-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
US20030119908A1 (en) * | 2001-12-21 | 2003-06-26 | Zambon Group S.P.A. | Stable gabapentin compositions |
ITMI20012750A1 (en) | 2001-12-21 | 2003-06-21 | Procos Spa | PROCESS FOR THE PRODUCTION OF 1- (AMINOMETHYL) -CYCLOHEXYL-ACETIC ACID IN PURE FORM |
US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
AU2003262383A1 (en) * | 2002-04-16 | 2003-11-03 | Taro Pharmaceutical Industries Ltd. | Process for preparing gabapentin |
CN1668284A (en) * | 2002-06-07 | 2005-09-14 | 兰贝克赛实验室有限公司 | Sustained release oral dosage forms of gabapentin |
CA2395931A1 (en) * | 2002-08-07 | 2004-02-07 | Bernard Charles Sherman | Solid compositions comprising gabapentin having improved stability |
ITMI20022071A1 (en) * | 2002-10-01 | 2004-04-02 | Erregierre Spa | SYNTHESIS PROCESS OF 1- (AMINOMETHYL) CYCLOHEXANACETIC HYDROCHLORIDE. |
WO2004032905A1 (en) * | 2002-10-08 | 2004-04-22 | Ranbaxy Laboratories Limited | Gabapentin tablets and methods for their preparation |
WO2004058168A2 (en) * | 2002-12-20 | 2004-07-15 | Dynogen Pharmaceuticals, Inc. | METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS |
BRPI0408608A (en) * | 2003-03-21 | 2006-03-07 | Dynogen Pharmaceuticals Inc | use of calcium channel subunit (alpha) 2 (delta) modulators and smooth muscle modulators to treat symptom of a lower urinary tract disorder |
US20040214893A1 (en) * | 2003-04-11 | 2004-10-28 | Matthew Peterson | Gabapentin compositions |
ITMI20030825A1 (en) * | 2003-04-18 | 2004-10-19 | Farchemia Srl | PROCEDURE FOR THE PREPARATION OF GABAPENTIN FREE FROM |
ITMI20031247A1 (en) | 2003-06-20 | 2004-12-21 | Zambon Spa | PROCESS FOR THE PURIFICATION OF GABAPENTINA |
US7169812B2 (en) * | 2003-07-01 | 2007-01-30 | Medtronic, Inc. | Process for producing injectable gabapentin compositions |
US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
WO2005046566A2 (en) * | 2003-08-04 | 2005-05-26 | Sun Pharmaceutical Industries Limited | Stable gabapentin containing composition |
JP2007505149A (en) * | 2003-09-11 | 2007-03-08 | ゼノポート,インコーポレイティド | Treatment and / or prevention of urinary incontinence with prodrugs of GABA analogs |
NZ545989A (en) * | 2003-09-17 | 2009-10-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
MXPA06004088A (en) | 2003-10-14 | 2006-06-27 | Xenoport Inc | Crystalline form of gamma-aminobutyric acid analog. |
US20050090548A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of epilepsy |
US20050090549A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of pain |
US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
US20050209319A1 (en) * | 2004-03-18 | 2005-09-22 | Xenoport, Inc. | Treatment of local pain |
ITMI20041447A1 (en) * | 2004-07-20 | 2004-10-20 | Zambon Spa | PHARMACEUTICAL COMPOSITION INCLUDING GABAPENTINA |
CN100361964C (en) * | 2005-06-13 | 2008-01-16 | 江苏恩华药业股份有限公司 | Gabapentin hydrochloride and its intermediate preparation method |
WO2007027476A2 (en) * | 2005-08-26 | 2007-03-08 | Xenoport, Inc. | Treating premature ejaculation using gabapentin and pregabalin prodrugs |
US20070092565A1 (en) * | 2005-10-25 | 2007-04-26 | Pharmascience Inc. | Gastric retention drug delivery system |
NL2000281C2 (en) | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Solid pharmaceutical compositions containing pregabalin. |
US20090176882A1 (en) | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
US7442834B2 (en) * | 2006-06-12 | 2008-10-28 | Zhejiang Chiral Medicine Chemicals Co., Ltd. | Process suitable for industrial scale production of gabapentin |
US20090286880A1 (en) * | 2006-07-12 | 2009-11-19 | Generics [Uk] Limited | Novel process |
US20080103334A1 (en) * | 2006-10-26 | 2008-05-01 | Ipca Laboratories Ltd | Process For Synthesis Of Gabapentin |
CN101652133A (en) * | 2006-12-08 | 2010-02-17 | 克塞诺波特公司 | The prodrug of GABA analog is used for the treatment of the purposes of disease |
EP2183211A1 (en) | 2007-07-27 | 2010-05-12 | Medichem, S.A. | Method for preparing polymorph form ii of gabapentin |
CN101462975B (en) * | 2008-08-19 | 2012-07-25 | 宁波九胜创新医药科技有限公司 | Preparation of high-purity gabapentin |
HU230031B1 (en) | 2010-03-01 | 2015-05-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Stabilized pharmaceutical composition containing pregabalin and isomalt |
EP2826477B1 (en) * | 2013-04-04 | 2017-05-31 | Daiichi Sankyo Company, Limited | Solid composition of amino carboxylate salt |
EP3272345B1 (en) | 2015-03-19 | 2019-10-16 | Daiichi Sankyo Company, Limited | Solid preparation containing antioxidant agent |
EP3437639A1 (en) | 2015-03-19 | 2019-02-06 | Daiichi Sankyo Company, Limited | Solid preparation containing colorant |
WO2019146642A1 (en) * | 2018-01-24 | 2019-08-01 | 大原薬品工業株式会社 | METHOD FOR IMPROVING CHEMICAL STABILITY OF γ-AMINOBUTYRIC ACID DERIVATIVE- CONTAINING TABLET |
RU2731536C1 (en) * | 2019-07-30 | 2020-09-04 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Pharmaceutical compositions containing fenosanic acid |
RU2736479C1 (en) * | 2019-07-30 | 2020-11-17 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Excipient-free pharmaceutical composition containing fenosanic acid |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
DE2543821C2 (en) * | 1974-12-21 | 1984-10-18 | Gödecke AG, 1000 Berlin | Certain salts and esters of 1-aminomethyl-1-cycloalkaneacetic acids and medicaments containing these compounds |
DE2460891C2 (en) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-aminomethyl-1-cycloalkaneacetic acids and their esters, processes for their preparation and medicaments containing these compounds |
DE2557220A1 (en) * | 1975-12-19 | 1977-06-23 | Goedecke Ag | N-SUBSTITUTED SPIROLACTAME |
DE2611690A1 (en) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | CYCLIC SULFONYLOXYIMIDE |
US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
-
1989
- 1989-08-25 DE DE3928183A patent/DE3928183A1/en not_active Withdrawn
-
1990
- 1990-08-21 MY MYPI90001397A patent/MY107056A/en unknown
- 1990-08-23 PT PT95082A patent/PT95082B/en not_active IP Right Cessation
- 1990-08-24 AT AT90116265T patent/ATE113272T1/en not_active IP Right Cessation
- 1990-08-24 DE DE59007550T patent/DE59007550D1/en not_active Expired - Lifetime
- 1990-08-24 DK DK90116265.1T patent/DK0414263T3/en active
- 1990-08-24 ES ES90116265T patent/ES2063219T3/en not_active Expired - Lifetime
- 1990-08-24 JP JP22142290A patent/JP3148223B2/en not_active Expired - Lifetime
- 1990-08-24 EP EP90116265A patent/EP0414263B1/en not_active Expired - Lifetime
- 1990-08-24 IE IE308990A patent/IE65291B1/en not_active IP Right Cessation
-
1995
- 1995-01-25 US US08/377,618 patent/US6054482A/en not_active Expired - Lifetime
-
1998
- 1998-03-24 HK HK98102503A patent/HK1003480A1/en not_active IP Right Cessation
-
2000
- 2000-09-06 JP JP2000270023A patent/JP3261123B2/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2206078A1 (en) * | 2000-10-23 | 2004-05-01 | Zambon Group S.P.A. | Process for the preparation of gabapentin |
US7199266B2 (en) | 2000-10-23 | 2007-04-03 | Zambon Group S.P.A. | Process for the preparation of gabapentin |
US7365227B2 (en) | 2000-10-23 | 2008-04-29 | Zach System S.P.A. | Process for the preparation of gabapentin |
Also Published As
Publication number | Publication date |
---|---|
IE65291B1 (en) | 1995-10-18 |
JP3148223B2 (en) | 2001-03-19 |
DE3928183A1 (en) | 1991-02-28 |
PT95082A (en) | 1991-04-18 |
JP3261123B2 (en) | 2002-02-25 |
IE903089A1 (en) | 1991-02-27 |
JPH0390053A (en) | 1991-04-16 |
US6054482A (en) | 2000-04-25 |
ATE113272T1 (en) | 1994-11-15 |
DE59007550D1 (en) | 1994-12-01 |
JP2001058976A (en) | 2001-03-06 |
EP0414263B1 (en) | 1994-10-26 |
EP0414263A2 (en) | 1991-02-27 |
DK0414263T3 (en) | 1995-01-16 |
EP0414263A3 (en) | 1991-06-05 |
HK1003480A1 (en) | 1998-10-30 |
MY107056A (en) | 1995-09-30 |
PT95082B (en) | 1997-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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