ES2062457T3 - Derivados de 1-(4-aminofenil)-2-piperidinopropanona, procedimiento de preparacion y utilizacion en terapeutica. - Google Patents
Derivados de 1-(4-aminofenil)-2-piperidinopropanona, procedimiento de preparacion y utilizacion en terapeutica.Info
- Publication number
- ES2062457T3 ES2062457T3 ES90403078T ES90403078T ES2062457T3 ES 2062457 T3 ES2062457 T3 ES 2062457T3 ES 90403078 T ES90403078 T ES 90403078T ES 90403078 T ES90403078 T ES 90403078T ES 2062457 T3 ES2062457 T3 ES 2062457T3
- Authority
- ES
- Spain
- Prior art keywords
- piperidinopropanone
- derivatives
- aminofenil
- therapeutics
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title 1
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
LA PRESENTE INVENCION CONSISTE EN UNOS DERIVADOS DE 1 4-AMINOFENIL) (A) LOS COMPUESTOS QUE RESPONDEN A LA FORMULA GENERAL DONDE R ES H O CH SUB 3 CO, A ES H O CI, B ES H O CI, Z ES ALQUILO EN C SUB 1 -C SUB 4; Y (B) SUS SALES DE ADICION. ESTOS PRODUCTOS SON UTILES COMO AGENTES CARDIOVASCULARES. EN PARTICULAR LOS COMPUESTOS DE LA FORMULA I, DONDE R = H O CH SUB 3 CO, A = B = CI Y Z = CH SUB 3, Y SUS SALES DE ADICION SON PARTICULARMENTE MUY INTERESANTES COMO AGENTES VASODILATADORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8914217A FR2653767B1 (fr) | 1989-10-30 | 1989-10-30 | Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2062457T3 true ES2062457T3 (es) | 1994-12-16 |
Family
ID=9386921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90403078T Expired - Lifetime ES2062457T3 (es) | 1989-10-30 | 1990-10-30 | Derivados de 1-(4-aminofenil)-2-piperidinopropanona, procedimiento de preparacion y utilizacion en terapeutica. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5128349A (es) |
| EP (1) | EP0426562B1 (es) |
| JP (1) | JPH03209364A (es) |
| AT (1) | ATE102924T1 (es) |
| CA (1) | CA2028764A1 (es) |
| DE (1) | DE69007422T2 (es) |
| DK (1) | DK0426562T3 (es) |
| ES (1) | ES2062457T3 (es) |
| FR (1) | FR2653767B1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| DE10344594A1 (de) * | 2003-09-25 | 2005-05-12 | Basf Ag | Verfahren zur Herstellung von Cyclododecanon |
| EP1889198B1 (en) | 2005-04-28 | 2014-11-26 | Proteus Digital Health, Inc. | Pharma-informatics system |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1618005A1 (de) * | 1966-09-22 | 1971-09-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen |
| DE1618007A1 (de) * | 1967-05-09 | 1970-10-29 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-monohalogenphenylaethanolaminen |
| GB1262965A (en) * | 1969-03-21 | 1972-02-09 | Ferrosan As | Butyrophenones |
| US4282206A (en) * | 1979-11-15 | 1981-08-04 | Westwood Pharmaceuticals Inc. | Method of protecting human skin from ultraviolet radiation |
| CA1250838A (fr) * | 1983-10-14 | 1989-03-07 | Louis Lafon | Procede de preparation de derives de 1-(acetylaminophenyl)-2-amino-propanone et les derives ainsi obtenus |
| FR2569184A1 (fr) * | 1984-08-20 | 1986-02-21 | Lafon Labor | Derives de 1-(aminophenyl) therapeutique et leur procede de preparation |
-
1989
- 1989-10-30 FR FR8914217A patent/FR2653767B1/fr not_active Expired - Lifetime
-
1990
- 1990-10-29 US US07/604,802 patent/US5128349A/en not_active Expired - Fee Related
- 1990-10-29 CA CA002028764A patent/CA2028764A1/en not_active Abandoned
- 1990-10-30 DE DE69007422T patent/DE69007422T2/de not_active Expired - Fee Related
- 1990-10-30 JP JP2290950A patent/JPH03209364A/ja active Pending
- 1990-10-30 AT AT90403078T patent/ATE102924T1/de not_active IP Right Cessation
- 1990-10-30 EP EP90403078A patent/EP0426562B1/fr not_active Expired - Lifetime
- 1990-10-30 ES ES90403078T patent/ES2062457T3/es not_active Expired - Lifetime
- 1990-10-30 DK DK90403078.0T patent/DK0426562T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2028764A1 (en) | 1991-05-01 |
| JPH03209364A (ja) | 1991-09-12 |
| US5128349A (en) | 1992-07-07 |
| FR2653767A1 (fr) | 1991-05-03 |
| FR2653767B1 (fr) | 1992-02-14 |
| DK0426562T3 (da) | 1994-07-25 |
| EP0426562A1 (fr) | 1991-05-08 |
| DE69007422T2 (de) | 1994-07-14 |
| EP0426562B1 (fr) | 1994-03-16 |
| ATE102924T1 (de) | 1994-04-15 |
| DE69007422D1 (de) | 1994-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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