ES2061453T3 - Composiciones farmaceuticas antivirales que contienen hipericina o pseudohipericina. - Google Patents
Composiciones farmaceuticas antivirales que contienen hipericina o pseudohipericina.Info
- Publication number
- ES2061453T3 ES2061453T3 ES87111467T ES87111467T ES2061453T3 ES 2061453 T3 ES2061453 T3 ES 2061453T3 ES 87111467 T ES87111467 T ES 87111467T ES 87111467 T ES87111467 T ES 87111467T ES 2061453 T3 ES2061453 T3 ES 2061453T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- pseudohipericina
- compositions containing
- hypericin
- antiviral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YDOIFHVUBCIUHF-UHFFFAOYSA-N 9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione Chemical compound OC1=CC(O)=C2C(O)=C3C(=O)C=C(C)C4=C5C(C)=CC(=O)C6=C(O)C7=C(O)C=C(O)C8=C7C(=C56)C(=C34)C2=C18 YDOIFHVUBCIUHF-UHFFFAOYSA-N 0.000 title abstract 2
- 229940005608 hypericin Drugs 0.000 title abstract 2
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000006819 RNA synthesis Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 208000003265 stomatitis Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 208000005925 vesicular stomatitis Diseases 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBE EL USO DE LA HIPERICINA O DE LA SEUDOHIPERICINA COMO SUSTANCIA TERAPEUTICAS ACTIVAS PARA EL TRATAMIENTO Y ALIVIO DE LOS SINTOMAS DE DIVERSAS ENFERMEDADES PRODUCIDAS POR VIRUS, TALES COMO LA ESTOMATITIS VESICULAR, LA GRIPE, EL HERPOS SIMPLEX, EL HSV-1 Y EL HSV-2. EL MODO DE ACTIVIDAD PARECE SER LA INHIBICION DE LA SINTESIS DEL RNA Y LA INTERFERENCIA CON LA REPLICACION DEL VIRUS. LAS COMPOSICIONES FARMACEUTICAS PUEDEN APLICARSE MEDIANTE UNA DIVERSIDAD DE VIAS. LAS APLICACIONES TOPICAS HAN DEMOSTRADO SER EFICACES CONTRA UNA VARIEDAD DE ENFERMEDADES VIRICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL79661A IL79661A (en) | 1986-08-08 | 1986-08-08 | Antiviral composition containing hypericin or pseudohypericin |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061453T3 true ES2061453T3 (es) | 1994-12-16 |
Family
ID=11057015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87111467T Expired - Lifetime ES2061453T3 (es) | 1986-08-08 | 1987-08-07 | Composiciones farmaceuticas antivirales que contienen hipericina o pseudohipericina. |
Country Status (6)
Country | Link |
---|---|
US (2) | US5047435A (es) |
EP (1) | EP0256452B1 (es) |
AT (1) | ATE96663T1 (es) |
DE (1) | DE3788016T2 (es) |
ES (1) | ES2061453T3 (es) |
IL (1) | IL79661A (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9309574B1 (en) | 1984-08-22 | 2016-04-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Molecular cloning of HIV-1 from immortalized cell lines |
EP0332679B1 (en) * | 1987-08-10 | 1993-06-16 | New York University | Antiviral compositions containing aromatic polycyclic diones and method for treating retrovirus infections |
AU3423989A (en) * | 1988-03-23 | 1989-10-16 | New York University | Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections |
AU3294289A (en) * | 1988-03-23 | 1989-10-16 | New York University | Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections |
IL93682A (en) * | 1989-03-16 | 1996-06-18 | Yeda Res & Dev | Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them |
US6187572B1 (en) | 1990-04-16 | 2001-02-13 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
US5316768A (en) | 1990-12-28 | 1994-05-31 | Murdock International Corporation | Pharmaceutical compositions having antiviral activity against human cytomegalovirus |
WO1993014197A1 (en) * | 1992-01-16 | 1993-07-22 | New York University | Hypericin treatment of vaccine agents for improved immunogenicity |
AU5959994A (en) * | 1992-12-23 | 1994-07-19 | Iowa State University Research Foundation Inc. | Molecular flashlight |
DE9316320U1 (de) * | 1993-10-20 | 1994-01-20 | Beni Med Natuerliche Heilmitte | Kosmetische Zubereitung in Form von Lippenstiften mit antiviraler Wirkung |
DE19547317A1 (de) * | 1995-12-18 | 1998-12-24 | Dreluso Pharm Dr Elten & Sohn | Antivirales Medikament |
GR1002799B (el) * | 1996-11-19 | 1997-11-04 | Αντιικη δραση του φυτου hypericum perforatum l. κατα του ανθρωπινου κυτταρομεγαλοιου. | |
IL119833A (en) * | 1996-12-15 | 2001-01-11 | Lavie David | Hypericum perforatum extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis |
US6428819B1 (en) | 1996-12-15 | 2002-08-06 | David Lavie | Plant extracts for the preparation of pharmaceutical compositions for the treatment of hepatitis |
DE19700788A1 (de) * | 1997-01-11 | 1998-07-16 | Michael O Ruepp | Johanniskraut-Trockenextrakte |
IL121440A0 (en) | 1997-07-31 | 1998-01-04 | Yeda Res & Dev | The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives |
JP2002509111A (ja) * | 1998-01-13 | 2002-03-26 | レクソール サンダウン インコーポレイテッド | オトギリソウ及びメチル供与体組成物、並びにその使用 |
US6238671B1 (en) | 1998-04-22 | 2001-05-29 | Bionorica Arzneimittel Gmbh | Process for the gentle recovery of extract fractions from hypericum, pharmaceutical preparations containing the same and their use |
US6159986A (en) * | 1999-11-02 | 2000-12-12 | Altman; David A. | Compounds and therapy for resisting memory loss in humans |
DE10131641A1 (de) | 2000-12-22 | 2002-06-27 | Schwabe Willmar Gmbh & Co | Verbesserter und stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und Verwendung als topisches Arzneimittel |
US7037534B2 (en) * | 2001-10-24 | 2006-05-02 | Aphios Corporation | Inactivation of viral infections agents by chemiluminescence activated light-sensitive compounds |
WO2004047821A1 (en) * | 2002-11-25 | 2004-06-10 | New York University | Methods for preventing phototoxic damage during photodynamic therapy |
US20100048728A1 (en) * | 2006-08-03 | 2010-02-25 | Hy Biopharma Inc. | Polycyclic dianthraquinones as inhibitors of inflammatory cytokines |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2707704A (en) * | 1951-09-29 | 1955-05-03 | Schenley Ind Inc | Process for the preparation of hypericin |
US4209532A (en) * | 1977-03-28 | 1980-06-24 | Union Carbide Corporation | Biocidal 2-aryl-1,3-cyclohexane dione compounds and alkali metal and ammonium salts thereof |
US4338122A (en) * | 1979-09-26 | 1982-07-06 | Union Carbide Corporation | Biocidal 2-aryl-1,3-cyclopentanedione compounds and alkali metal and ammonium salts thereof |
ATE8790T1 (de) * | 1981-02-02 | 1984-08-15 | Schering Corporation | Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. |
US4540700A (en) * | 1982-04-15 | 1985-09-10 | Alcon Laboratories, Inc. | Treatment of diabetic complications with certain spiro-imidazolidine-diones |
JPS59190921A (ja) * | 1983-04-11 | 1984-10-29 | Junko Nozaki | 抗ウイルス活性物質 |
-
1986
- 1986-08-08 IL IL79661A patent/IL79661A/xx not_active IP Right Cessation
-
1987
- 1987-08-07 AT AT87111467T patent/ATE96663T1/de not_active IP Right Cessation
- 1987-08-07 ES ES87111467T patent/ES2061453T3/es not_active Expired - Lifetime
- 1987-08-07 EP EP87111467A patent/EP0256452B1/en not_active Expired - Lifetime
- 1987-08-07 DE DE87111467T patent/DE3788016T2/de not_active Expired - Fee Related
-
1989
- 1989-03-27 US US07/328,767 patent/US5047435A/en not_active Expired - Fee Related
- 1989-12-19 US US07/452,436 patent/US5049589A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5049589A (en) | 1991-09-17 |
IL79661A (en) | 1991-01-31 |
DE3788016D1 (de) | 1993-12-09 |
IL79661A0 (en) | 1987-08-31 |
EP0256452A3 (en) | 1990-01-17 |
ATE96663T1 (de) | 1993-11-15 |
US5047435A (en) | 1991-09-10 |
EP0256452B1 (en) | 1993-11-03 |
EP0256452A2 (en) | 1988-02-24 |
DE3788016T2 (de) | 1994-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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