ES2060164T3 - Preparacion por oxidacion de acido a-nor-17beta-carboxi-3,5-secoandrostan-5-ona-3-oico. - Google Patents

Preparacion por oxidacion de acido a-nor-17beta-carboxi-3,5-secoandrostan-5-ona-3-oico.

Info

Publication number
ES2060164T3
ES2060164T3 ES90907573T ES90907573T ES2060164T3 ES 2060164 T3 ES2060164 T3 ES 2060164T3 ES 90907573 T ES90907573 T ES 90907573T ES 90907573 T ES90907573 T ES 90907573T ES 2060164 T3 ES2060164 T3 ES 2060164T3
Authority
ES
Spain
Prior art keywords
secoandrostan
carboxi
17beta
ona
oxidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90907573T
Other languages
English (en)
Inventor
Paul Matthew Herrinton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ES2060164T3 publication Critical patent/ES2060164T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/24—Saturated compounds containing keto groups the keto group being part of a ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/26—Saturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION ES UN PROCESO OXIDANTE PARA LA CONVERSION DE PROGESTERONAS 21-INSATURADAS (I) A LOS CORRESPONDIENTES ACIDOS 3.5-SECONANDROST-5-ONO-3,17(BETA)-DIOCO (II) MEDIANTE EL USO DE U OZONO O UN AGENTE OXIDANTE, UTILES INTERMEDIARIOS EN LA PRODUCCION DE ESTEROIDES A ELEVADO 5-4-AZA 17-CARBONIL (III) UTILES EN LA PRODUCCION DE PRODUCTOS FARMACEUTICOS AMIDA (IV) 5(ALFA)-4-4AZA. TAMBIEN SE PRESENTA PROGESTERONAS 21-INSATURADAS NUEVAS (I-C) Y ACIDOS 3,5-SECOANDROST-5ONO-3,17(BETA)-DIOCOS.
ES90907573T 1989-05-30 1990-05-15 Preparacion por oxidacion de acido a-nor-17beta-carboxi-3,5-secoandrostan-5-ona-3-oico. Expired - Lifetime ES2060164T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35880089A 1989-05-30 1989-05-30
US46241790A 1990-01-09 1990-01-09

Publications (1)

Publication Number Publication Date
ES2060164T3 true ES2060164T3 (es) 1994-11-16

Family

ID=27000201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90907573T Expired - Lifetime ES2060164T3 (es) 1989-05-30 1990-05-15 Preparacion por oxidacion de acido a-nor-17beta-carboxi-3,5-secoandrostan-5-ona-3-oico.

Country Status (10)

Country Link
EP (1) EP0474666B1 (es)
JP (1) JP2863786B2 (es)
AT (1) ATE111435T1 (es)
AU (1) AU5650590A (es)
CA (1) CA2051397C (es)
DE (1) DE69012558T2 (es)
DK (1) DK0474666T3 (es)
ES (1) ES2060164T3 (es)
HK (1) HK64997A (es)
WO (1) WO1990015045A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187925B1 (en) 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2727905A (en) * 1952-08-21 1955-12-20 Upjohn Co Steroid alkali-metal enolates
FR1510055A (fr) * 1966-12-06 1968-01-19 Centre Nat Rech Scient Procédé de préparation de seco-4-nor-céto-acides
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors

Also Published As

Publication number Publication date
HK64997A (en) 1997-05-23
CA2051397C (en) 1997-12-09
JPH04505451A (ja) 1992-09-24
WO1990015045A1 (en) 1990-12-13
EP0474666A1 (en) 1992-03-18
CA2051397A1 (en) 1991-07-10
DK0474666T3 (da) 1995-02-06
ATE111435T1 (de) 1994-09-15
AU5650590A (en) 1991-01-07
JP2863786B2 (ja) 1999-03-03
DE69012558D1 (de) 1994-10-20
DE69012558T2 (de) 1995-02-23
EP0474666B1 (en) 1994-09-14

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