ES2058922T3 - Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre. - Google Patents

Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre.

Info

Publication number
ES2058922T3
ES2058922T3 ES90910036T ES90910036T ES2058922T3 ES 2058922 T3 ES2058922 T3 ES 2058922T3 ES 90910036 T ES90910036 T ES 90910036T ES 90910036 T ES90910036 T ES 90910036T ES 2058922 T3 ES2058922 T3 ES 2058922T3
Authority
ES
Spain
Prior art keywords
iii
miocardio
man
agents
contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910036T
Other languages
English (en)
Inventor
Edward A Deutsch
Karen F Libson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Cincinnati
Original Assignee
University of Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Cincinnati filed Critical University of Cincinnati
Application granted granted Critical
Publication of ES2058922T3 publication Critical patent/ES2058922T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UN AGENTE DE VISUALIZACION DE IMAGENES MIOCARDICAS PARA HUMANOS ES UN COMPLEJO TECNECIO (III) LIGADO EN LAS POSICIONES PLANARES MEDIANTE UNA LIGADURA TETRADENTADO TALES COMO (ACAC) SUB 2 EN Y EN LAS POSICIONES AXIALES MEDIANTE UN ETER QUE CONTIENE LIGADURA FOSFINA TAL COMO TRIS(3 -MTOXI-1PROPIL)-FOSFINA. EL AGENTE EXHIBE UN DESPEJE DE SANGRE EXTREMADAMENTE RAPIDO DESPUES DE LA INYECCION EN UN HUMANO (COMO SE MUESTRA EN LAS FIGURAS) Y TIENE UNOS INDICES SUFICIENTEMENTE ALTOS DE CORAZON/HIGADO Y CORAZON/PULMONES COMO PARA PROPORCIONAR IMAGENES MIOCARDICAS EFECTIVAS.
ES90910036T 1989-05-19 1990-03-20 Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre. Expired - Lifetime ES2058922T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/354,491 US4917879A (en) 1989-05-19 1989-05-19 99MTC(III) myocardial imaging agents that are effective in humans

Publications (1)

Publication Number Publication Date
ES2058922T3 true ES2058922T3 (es) 1994-11-01

Family

ID=23393570

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910036T Expired - Lifetime ES2058922T3 (es) 1989-05-19 1990-03-20 Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre.

Country Status (10)

Country Link
US (1) US4917879A (es)
EP (1) EP0472665B1 (es)
JP (1) JPH0776182B2 (es)
AT (1) ATE92341T1 (es)
AU (1) AU633597B2 (es)
CA (1) CA2051699A1 (es)
DE (1) DE69002627T2 (es)
DK (1) DK0472665T3 (es)
ES (1) ES2058922T3 (es)
WO (1) WO1990014106A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68904905T2 (de) * 1988-03-09 1993-07-22 Cis Bio Int Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.
US4957728A (en) * 1989-05-19 1990-09-18 University Of Cincinnati Kit for preparing Tc (III)-99m myocardial imaging agents that are effective in humans
US5908931A (en) * 1990-12-14 1999-06-01 Mallinckrodt Inc. Preorganized hexadentate ligands useful in radiographic imaging agents
US5112594A (en) * 1991-04-04 1992-05-12 Mallinckrodt Medical, Inc. Kit for preparing a technetium-99m myocardial imaging agent
US5112595A (en) * 1990-12-21 1992-05-12 Mallinckrodt Medical, Inc. 99MTC(III) myocardial imaging agents and method of use
US5300280A (en) * 1992-02-14 1994-04-05 Mallinckrodt Medical, Inc. Stabilized radiopharmaceutical kits
JPH08505398A (ja) * 1993-01-06 1996-06-11 マリンクロット・メディカル・インコーポレイテッド 放射線撮影イメージング剤に有用な六座配位子類
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5541289A (en) * 1994-03-30 1996-07-30 Washington University Phosphine containing amino acids and peptides and methods of preparing and using same
CA2166676C (en) * 1995-01-09 2007-05-01 Yasuhisa Fujibayashi Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758682A (en) * 1983-03-17 1988-07-19 California Institute Of Technology Homogeneous coordination compounds as oxidation catalysts
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
CA1300608C (en) * 1985-05-10 1992-05-12 Edward A. Deutsch 99 mtc (iii) myocardial imaging agents which are non-reducable in vivo
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m

Also Published As

Publication number Publication date
AU5845390A (en) 1990-12-18
US4917879A (en) 1990-04-17
WO1990014106A3 (en) 1991-07-25
AU633597B2 (en) 1993-02-04
JPH04505622A (ja) 1992-10-01
DE69002627T2 (de) 1993-11-11
JPH0776182B2 (ja) 1995-08-16
ATE92341T1 (de) 1993-08-15
WO1990014106A2 (en) 1990-11-29
DK0472665T3 (da) 1994-01-03
EP0472665A1 (en) 1992-03-04
CA2051699A1 (en) 1990-11-20
EP0472665B1 (en) 1993-08-04
DE69002627D1 (de) 1993-09-09

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