ES2058922T3 - Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre. - Google Patents
Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre.Info
- Publication number
- ES2058922T3 ES2058922T3 ES90910036T ES90910036T ES2058922T3 ES 2058922 T3 ES2058922 T3 ES 2058922T3 ES 90910036 T ES90910036 T ES 90910036T ES 90910036 T ES90910036 T ES 90910036T ES 2058922 T3 ES2058922 T3 ES 2058922T3
- Authority
- ES
- Spain
- Prior art keywords
- iii
- miocardio
- man
- agents
- contrast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN AGENTE DE VISUALIZACION DE IMAGENES MIOCARDICAS PARA HUMANOS ES UN COMPLEJO TECNECIO (III) LIGADO EN LAS POSICIONES PLANARES MEDIANTE UNA LIGADURA TETRADENTADO TALES COMO (ACAC) SUB 2 EN Y EN LAS POSICIONES AXIALES MEDIANTE UN ETER QUE CONTIENE LIGADURA FOSFINA TAL COMO TRIS(3 -MTOXI-1PROPIL)-FOSFINA. EL AGENTE EXHIBE UN DESPEJE DE SANGRE EXTREMADAMENTE RAPIDO DESPUES DE LA INYECCION EN UN HUMANO (COMO SE MUESTRA EN LAS FIGURAS) Y TIENE UNOS INDICES SUFICIENTEMENTE ALTOS DE CORAZON/HIGADO Y CORAZON/PULMONES COMO PARA PROPORCIONAR IMAGENES MIOCARDICAS EFECTIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/354,491 US4917879A (en) | 1989-05-19 | 1989-05-19 | 99MTC(III) myocardial imaging agents that are effective in humans |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058922T3 true ES2058922T3 (es) | 1994-11-01 |
Family
ID=23393570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90910036T Expired - Lifetime ES2058922T3 (es) | 1989-05-19 | 1990-03-20 | Agentes 99m tc(iii) de contraste para el miocardio, eficaces en el hombre. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4917879A (es) |
EP (1) | EP0472665B1 (es) |
JP (1) | JPH0776182B2 (es) |
AT (1) | ATE92341T1 (es) |
AU (1) | AU633597B2 (es) |
CA (1) | CA2051699A1 (es) |
DE (1) | DE69002627T2 (es) |
DK (1) | DK0472665T3 (es) |
ES (1) | ES2058922T3 (es) |
WO (1) | WO1990014106A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU619538B2 (en) * | 1988-03-09 | 1992-01-30 | Cis Bio International | Preparation of nitruro compounds usable as radio-pharmaceutical products |
US4957728A (en) * | 1989-05-19 | 1990-09-18 | University Of Cincinnati | Kit for preparing Tc (III)-99m myocardial imaging agents that are effective in humans |
US5908931A (en) * | 1990-12-14 | 1999-06-01 | Mallinckrodt Inc. | Preorganized hexadentate ligands useful in radiographic imaging agents |
US5112594A (en) * | 1991-04-04 | 1992-05-12 | Mallinckrodt Medical, Inc. | Kit for preparing a technetium-99m myocardial imaging agent |
US5112595A (en) * | 1990-12-21 | 1992-05-12 | Mallinckrodt Medical, Inc. | 99MTC(III) myocardial imaging agents and method of use |
US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
WO1994015647A1 (en) * | 1993-01-06 | 1994-07-21 | Mallinckrodt Medical, Inc. | Hexadentate ligands useful in radiographic imaging agents |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
US5541289A (en) * | 1994-03-30 | 1996-07-30 | Washington University | Phosphine containing amino acids and peptides and methods of preparing and using same |
CA2166676C (en) * | 1995-01-09 | 2007-05-01 | Yasuhisa Fujibayashi | Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758682A (en) * | 1983-03-17 | 1988-07-19 | California Institute Of Technology | Homogeneous coordination compounds as oxidation catalysts |
US4795626A (en) * | 1985-05-10 | 1989-01-03 | University Of Cincinnati | 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo |
CA1300608C (en) * | 1985-05-10 | 1992-05-12 | Edward A. Deutsch | 99 mtc (iii) myocardial imaging agents which are non-reducable in vivo |
GB8723438D0 (en) * | 1987-10-06 | 1987-11-11 | Amersham Int Plc | Cationic complexes of technetium-99m |
-
1989
- 1989-05-19 US US07/354,491 patent/US4917879A/en not_active Expired - Fee Related
-
1990
- 1990-03-20 EP EP90910036A patent/EP0472665B1/en not_active Expired - Lifetime
- 1990-03-20 ES ES90910036T patent/ES2058922T3/es not_active Expired - Lifetime
- 1990-03-20 JP JP2509078A patent/JPH0776182B2/ja not_active Expired - Lifetime
- 1990-03-20 AU AU58453/90A patent/AU633597B2/en not_active Ceased
- 1990-03-20 CA CA002051699A patent/CA2051699A1/en not_active Abandoned
- 1990-03-20 DK DK90910036.4T patent/DK0472665T3/da active
- 1990-03-20 WO PCT/US1990/001497 patent/WO1990014106A2/en active IP Right Grant
- 1990-03-20 DE DE90910036T patent/DE69002627T2/de not_active Expired - Fee Related
- 1990-03-20 AT AT90910036T patent/ATE92341T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU633597B2 (en) | 1993-02-04 |
ATE92341T1 (de) | 1993-08-15 |
CA2051699A1 (en) | 1990-11-20 |
EP0472665A1 (en) | 1992-03-04 |
DE69002627T2 (de) | 1993-11-11 |
WO1990014106A3 (en) | 1991-07-25 |
AU5845390A (en) | 1990-12-18 |
DK0472665T3 (da) | 1994-01-03 |
EP0472665B1 (en) | 1993-08-04 |
JPH0776182B2 (ja) | 1995-08-16 |
DE69002627D1 (de) | 1993-09-09 |
JPH04505622A (ja) | 1992-10-01 |
US4917879A (en) | 1990-04-17 |
WO1990014106A2 (en) | 1990-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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