ES2057045T3 - Procedimiento para la determinacion de osteocalcina en plasma o suero humano. - Google Patents
Procedimiento para la determinacion de osteocalcina en plasma o suero humano.Info
- Publication number
- ES2057045T3 ES2057045T3 ES89118250T ES89118250T ES2057045T3 ES 2057045 T3 ES2057045 T3 ES 2057045T3 ES 89118250 T ES89118250 T ES 89118250T ES 89118250 T ES89118250 T ES 89118250T ES 2057045 T3 ES2057045 T3 ES 2057045T3
- Authority
- ES
- Spain
- Prior art keywords
- plasma
- osteocalcin
- tracer
- human serum
- determination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002966 serum Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000700 radioactive tracer Substances 0.000 abstract 5
- 108010038807 Oligopeptides Proteins 0.000 abstract 4
- 102000015636 Oligopeptides Human genes 0.000 abstract 4
- 102000004067 Osteocalcin Human genes 0.000 abstract 4
- 108090000573 Osteocalcin Proteins 0.000 abstract 4
- 229940124143 Endopeptidase inhibitor Drugs 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 229940097396 Aminopeptidase inhibitor Drugs 0.000 abstract 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 abstract 1
- 108010052590 amastatin Proteins 0.000 abstract 1
- QFAADIRHLBXJJS-ZAZJUGBXSA-N amastatin Chemical compound CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC(O)=O QFAADIRHLBXJJS-ZAZJUGBXSA-N 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 108010052968 leupeptin Proteins 0.000 abstract 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3833936A DE3833936C1 (OSRAM) | 1988-10-05 | 1988-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2057045T3 true ES2057045T3 (es) | 1994-10-16 |
Family
ID=6364464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89118250T Expired - Lifetime ES2057045T3 (es) | 1988-10-05 | 1989-10-02 | Procedimiento para la determinacion de osteocalcina en plasma o suero humano. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5168041A (OSRAM) |
| EP (1) | EP0362773B1 (OSRAM) |
| JP (1) | JPH02147954A (OSRAM) |
| AT (1) | ATE110854T1 (OSRAM) |
| DE (2) | DE3833936C1 (OSRAM) |
| ES (1) | ES2057045T3 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05232109A (ja) * | 1990-10-04 | 1993-09-07 | Teijin Ltd | ヒト・オステオカルシンプロ蛋白の測定方法 |
| US5541116A (en) * | 1991-09-30 | 1996-07-30 | B.R.A.H.M.S. Diagnostica Gmbh | Method for the stabilization of endogenous, physiologically active peptides |
| US6632613B1 (en) * | 1993-06-02 | 2003-10-14 | University Of Utah Research Foundation | Compositions and kits for fluorescence polarization assay of large molecules |
| DE4340597C2 (de) * | 1993-11-29 | 1995-11-30 | Brahms Diagnostica Gmbh | Verfahren zur Verhinderung des Abbaus von Osteocalcin in humanem Serum oder Plasma f}r seine nachfolgende Bestimmung sowie Instrumente und Probengef{ße zur Durchf}hrung dieses Verfahrens |
| ATE256702T1 (de) * | 1993-12-09 | 2004-01-15 | Univ Utah Res Found | Zusammensetzungen und kits zur fluoreszenzpolarisierungsdosierung von grossen molekülen |
| US20040259167A1 (en) * | 1997-08-15 | 2004-12-23 | Jukka Hellman | Isolated osteocalcin fragments |
| DE19903336C2 (de) * | 1999-01-28 | 2000-12-14 | Brahms Diagnostica Gmbh | Gebrauchsfertige Kalibratoren für die Bestimmung von Procalcitonin |
| CH695985A5 (de) * | 2002-01-21 | 2006-11-15 | Straumann Holding Ag | Oberflächenmodifizierte Implantate. |
| DE10231574A1 (de) * | 2002-07-11 | 2004-01-29 | Sartorius Ag | Membran, Vorrichtung und Verfahren zum Entfernen von Proteasen aus Flüssigkeiten |
| EP2150816B1 (en) * | 2007-01-16 | 2014-11-26 | Mayo Foundation For Medical Education And Research | Assessing mammals for vascular diseases |
| JP4947725B2 (ja) * | 2008-03-28 | 2012-06-06 | ヤマサ醤油株式会社 | ジアセチルポリアミンの分解防止法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
| US4410506A (en) * | 1981-03-24 | 1983-10-18 | The Regents Of The University Of California | Immunoassay for vitamin K-dependent bone protein |
| US4438208A (en) * | 1982-05-27 | 1984-03-20 | The Regents Of The University Of California | Region-specific determinants for vitamin K dependent bone protein |
| US4505853A (en) * | 1983-11-18 | 1985-03-19 | Ortho Pharmaceutical Corporation | Enzyme-resistant immunomodulatory peptides |
| US4981952A (en) * | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
-
1988
- 1988-10-05 DE DE3833936A patent/DE3833936C1/de not_active Expired
-
1989
- 1989-10-02 AT AT89118250T patent/ATE110854T1/de not_active IP Right Cessation
- 1989-10-02 ES ES89118250T patent/ES2057045T3/es not_active Expired - Lifetime
- 1989-10-02 EP EP89118250A patent/EP0362773B1/de not_active Expired - Lifetime
- 1989-10-02 DE DE58908270T patent/DE58908270D1/de not_active Expired - Fee Related
- 1989-10-03 JP JP1258638A patent/JPH02147954A/ja active Pending
- 1989-10-03 US US07/416,728 patent/US5168041A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE110854T1 (de) | 1994-09-15 |
| US5168041A (en) | 1992-12-01 |
| DE58908270D1 (de) | 1994-10-06 |
| JPH02147954A (ja) | 1990-06-06 |
| DE3833936C1 (OSRAM) | 1989-09-21 |
| EP0362773A2 (de) | 1990-04-11 |
| EP0362773B1 (de) | 1994-08-31 |
| EP0362773A3 (de) | 1991-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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