ES2057043T5 - Procedimiento para la micronizacion de glibenclamida. - Google Patents

Procedimiento para la micronizacion de glibenclamida.

Info

Publication number
ES2057043T5
ES2057043T5 ES89117998T ES89117998T ES2057043T5 ES 2057043 T5 ES2057043 T5 ES 2057043T5 ES 89117998 T ES89117998 T ES 89117998T ES 89117998 T ES89117998 T ES 89117998T ES 2057043 T5 ES2057043 T5 ES 2057043T5
Authority
ES
Spain
Prior art keywords
glibenclamide
micronization
procedure
microfine
entails
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89117998T
Other languages
English (en)
Other versions
ES2057043T3 (es
Inventor
Ottmar Dr Jaenicke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6364187&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2057043(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2057043T3 publication Critical patent/ES2057043T3/es
Application granted granted Critical
Publication of ES2057043T5 publication Critical patent/ES2057043T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA ELABORACION DE UNA FORMA MICRONIZADA DE GLIBENCLAMIDA DON FORMULA (I) CON UNA SUPERFICIE DE PARTICULAS ACTIVAS DE POR LE MENOS M (AL CUADRADO) /G DSEGUN BET. PARA ELLO, SE ACIDULA CON UN ACIDO LA SUSPENSION EN AGUA DE UNA SAL POCO SOLUBLE DE LA GLIBENCLAMIDA, CON LO QUE SE ORIGINA EL PRECIPITADO DE GLIBENCLAMIDA MICROFINA.
ES89117998T 1988-10-01 1989-09-28 Procedimiento para la micronizacion de glibenclamida. Expired - Lifetime ES2057043T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3833439A DE3833439A1 (de) 1988-10-01 1988-10-01 Verfahren zur mikronisierung von glibenclamid

Publications (2)

Publication Number Publication Date
ES2057043T3 ES2057043T3 (es) 1994-10-16
ES2057043T5 true ES2057043T5 (es) 1996-11-01

Family

ID=6364187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89117998T Expired - Lifetime ES2057043T5 (es) 1988-10-01 1989-09-28 Procedimiento para la micronizacion de glibenclamida.

Country Status (11)

Country Link
EP (1) EP0362704B2 (es)
JP (1) JPH02149516A (es)
AT (1) ATE89268T1 (es)
AU (1) AU620448B2 (es)
DE (2) DE3833439A1 (es)
ES (1) ES2057043T5 (es)
FI (1) FI894598A (es)
GR (1) GR3020754T3 (es)
NZ (1) NZ230828A (es)
PT (1) PT91835A (es)
ZA (1) ZA897421B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT974356E (pt) * 1998-07-15 2004-02-27 Merck Sante Sas Comprimidos compreendendo uma combinacao de metformina e de glibenclamida
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
CN1450902A (zh) * 1999-11-03 2003-10-22 布里斯托尔-迈尔斯斯奎布公司 包含二甲双胍和格列本脲组合的药用组合物
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
PL2868315T3 (pl) 2007-12-04 2018-06-29 Biogen Chesapeake Llc Udoskonalone preparaty i sposoby liofilizacji oraz uzyskiwane liofilizaty
DE102008000351B4 (de) 2008-02-20 2017-08-10 Aristo Pharma Gmbh Verfahren zur Herstellung eines Ebastin enthaltenden Granulats sowie einer festen pharmazeutischen Zusammensetzung, Ebastin enthaltendes Granulat und dessen Verwendung
FR2987268B1 (fr) 2012-02-28 2014-07-11 Ammtek Formulations liquides de sulfamides hypoglycemiants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD91647A (es) *
DE1301812B (de) * 1965-07-27 1969-08-28 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
CA889876A (en) * 1970-09-10 1972-01-04 Frank W. Horner Limited Purification of glyburide
NL7314765A (es) * 1972-10-31 1974-05-02
DE2348334C2 (de) * 1973-09-26 1982-11-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs
DD204915B1 (de) * 1981-12-16 1986-05-07 Goldner Richard Verfahren zur herstellung von reinem n-(4-(beta- geschweifte klammer auf 2-methoxy-5-chlor-benzamido geschweifte klammer zu -aethyl)-phenylsulfonyl)-n'-cyclohexylharnstoff
DD248115A1 (de) * 1984-04-11 1987-07-29 Dresden Arzneimittel Verfahren zur herstellung von n-(4-(ss- 5-chlor-2-methoxy-benzamido -ethyl)-phenylsulfonyl)-n'-cyclohexylharnstoff in feiner verteilung
RO89209A2 (ro) * 1984-06-12 1986-05-30 Intreprinderea De Medicamente Si Coloranti"Sintofarm",Ro Procedeu pentru obtinerea de glibenclamid sub forma de microparticule

Also Published As

Publication number Publication date
ATE89268T1 (de) 1993-05-15
EP0362704A1 (de) 1990-04-11
AU4230289A (en) 1990-04-05
DE3833439A1 (de) 1991-09-12
ES2057043T3 (es) 1994-10-16
ZA897421B (en) 1990-06-27
AU620448B2 (en) 1992-02-20
DE58904332D1 (de) 1993-06-17
FI894598A (fi) 1990-04-02
PT91835A (pt) 1990-04-30
GR3020754T3 (en) 1996-11-30
NZ230828A (en) 1991-07-26
FI894598A0 (fi) 1989-09-28
JPH02149516A (ja) 1990-06-08
EP0362704B1 (de) 1993-05-12
EP0362704B2 (de) 1996-08-07

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