ES2056246T3 - Derivados de n-hetaril-imidazol. - Google Patents

Derivados de n-hetaril-imidazol.

Info

Publication number
ES2056246T3
ES2056246T3 ES89730160T ES89730160T ES2056246T3 ES 2056246 T3 ES2056246 T3 ES 2056246T3 ES 89730160 T ES89730160 T ES 89730160T ES 89730160 T ES89730160 T ES 89730160T ES 2056246 T3 ES2056246 T3 ES 2056246T3
Authority
ES
Spain
Prior art keywords
branched
hydrogen
straight
chain
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89730160T
Other languages
English (en)
Inventor
Ralph Dr Rohde
Helmut Dr Biere
Ralph Dr Schmiechen
John Stuart Andrews
David Norman Dr Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2056246T3 publication Critical patent/ES2056246T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EL INVENTO SE REFIERE A UN DERIVADO DE N - METARILO - IMIDAZOL DE FORMULA (I). TAMBIEN SE DESCRIBE EL PROCEDIMIENTO DE OBTENCION DE DICHO DERIVADO Y SU APLICACION COMO MEDICAMENTO. SIENDO; HET UN HETEROATOMO MONO O BICICLICO SUBSTITUIDO; R3 HIDROGENO, UN GRUPO ALQUILO DE C 1 A 6 DE CADENA RECTA O RAMIFICADA O UN GRUPO ALCOXIALQUILO DE C 1 A 6; R4 -COOR5, - CONR6R7, -CN Y LOS RADICALES (II) O (III); R5 H, R4 UNA CADENA RECTA O RAMIFICADA DE UN GRUPO ALQUILO DE C 1 A 6; R6 Y R7 IGUALES O DIFERENTES, HIDROGENO O UN GRUPO ALQUILO CICLICO, O DE CADENA RECTA O RAMIFICADA CON SIETE ATOMOS DE CARBONO O CON EL ATOMO DE NITROGENO FORMAN UN ANILLO DE CINCO O SEIS MIEMBROS SATURADO QUE CONTIENE UN HETEROATOMO Y R8 HIDROGENO O UN GRUPO ALQUILO DE CADENA RECTA, RAMIFICADA O CICLICA DE SIETE CARBONOS.
ES89730160T 1988-07-15 1989-07-12 Derivados de n-hetaril-imidazol. Expired - Lifetime ES2056246T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3824658A DE3824658A1 (de) 1988-07-15 1988-07-15 N-hetaryl-imidazolderivate

Publications (1)

Publication Number Publication Date
ES2056246T3 true ES2056246T3 (es) 1994-10-01

Family

ID=6359160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89730160T Expired - Lifetime ES2056246T3 (es) 1988-07-15 1989-07-12 Derivados de n-hetaril-imidazol.

Country Status (6)

Country Link
US (1) US4987146A (es)
EP (1) EP0358595B1 (es)
JP (1) JPH02142788A (es)
AT (1) ATE105557T1 (es)
DE (2) DE3824658A1 (es)
ES (1) ES2056246T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022858D0 (en) * 1990-10-20 1990-12-05 Reckitt & Colmann Prod Ltd Derivatives of indoles
DE4112451A1 (de) * 1991-04-12 1992-10-15 Schering Ag Isoxazolylimidazolderivate, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5447949A (en) * 1991-05-15 1995-09-05 Smithkline Beecham Corporation N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity
US5252590A (en) * 1991-06-28 1993-10-12 Sumitomo Chemical Company, Limited 1-pyridylimidazole derivative
IL113358A (en) * 1995-04-13 1998-03-10 Supercom Ltd Method and device for printing on passports and the like
JP3964478B2 (ja) * 1995-06-30 2007-08-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
US6072057A (en) * 1996-06-06 2000-06-06 Gliatech Inc. 1H-4(5)-cyclo-substituted imidazole derivatives as histamine H3 receptor agents
EA200000840A1 (ru) 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
US6410726B1 (en) 2000-01-12 2002-06-25 Tularik Inc. Arylsulfonic acid salts of pyrimidine-based antiviral
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP1434774A1 (en) 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
RU2531354C2 (ru) 2008-04-28 2014-10-20 Янссен Фармацевтика Нв Бензоимидазолы как ингибиторы пролилгидроксилазы
WO2012052412A1 (de) 2010-10-22 2012-04-26 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
BR112014009910B1 (pt) 2011-10-25 2020-06-30 Janssen Pharmaceutica N.V. sal di-hidrato de meglumina de ácido 1-(5,6-dicloro-1h-benzo[d]imidazol-2-il)-1h-pirazol-4-carboxílico, composição farmacêuticae pomada tópica
CN115135384B (zh) 2019-11-28 2024-03-22 日本农药株式会社 苯并咪唑化合物或其盐类、和含有该化合物的农艺和园艺用杀虫杀螨剂以及其使用方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT374198B (de) * 1979-04-10 1984-03-26 Ciba Geigy Ag Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate, ihrer n-oxyde und ihrer salze
DE3246705C2 (de) * 1981-12-24 1986-07-10 Kureha Kagaku Kogyo K.K., Tokio/Tokyo Tetrahydrobenzthiazolderivate und diese Verbindungen als wirksamen Bestandteil enthaltende herbizide Mittel
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
GB8301426D0 (en) * 1983-01-19 1983-02-23 Automotive Prod Plc Friction clutches
JPS59186979A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd テトラヒドロベンゾチアゾ−ル誘導体及び該誘導体を含有する除草剤
JPS6092285A (ja) * 1983-10-26 1985-05-23 Shionogi & Co Ltd イソオキサゾ−ル系環状尿素類
US4600430A (en) * 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
AU581763B2 (en) * 1985-06-14 1989-03-02 Ppg Industries, Inc. Herbicidal imidazolidinone derivatives
US4756744A (en) * 1985-06-24 1988-07-12 Ppg Industries, Inc. Herbicidally active 4-aminoalkylamino-3-isoxazolyl-2-imidazolidinone derivatives
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
GB8612796D0 (en) * 1986-05-27 1986-07-02 Fbc Ltd Fungicides
DE3620430A1 (de) * 1986-06-18 1987-12-23 Basf Ag Verfahren zur herstellung von hexaarylbisimidazolen
EP0305330A1 (de) * 1987-08-25 1989-03-01 Ciba-Geigy Ag Imidazolderivate
DE3742716A1 (de) * 1987-12-14 1989-06-22 Schering Ag Imidazolderivate ii

Also Published As

Publication number Publication date
US4987146A (en) 1991-01-22
JPH02142788A (ja) 1990-05-31
DE3824658A1 (de) 1990-01-18
ATE105557T1 (de) 1994-05-15
DE58907635D1 (de) 1994-06-23
EP0358595B1 (de) 1994-05-11
EP0358595A1 (de) 1990-03-14

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