ES2055652B1 - PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. - Google Patents

PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

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Publication number
ES2055652B1
ES2055652B1 ES9201890A ES9201890A ES2055652B1 ES 2055652 B1 ES2055652 B1 ES 2055652B1 ES 9201890 A ES9201890 A ES 9201890A ES 9201890 A ES9201890 A ES 9201890A ES 2055652 B1 ES2055652 B1 ES 2055652B1
Authority
ES
Spain
Prior art keywords
obtaining
methyl
procedure
dihidropiridin
dicarboxilato
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9201890A
Other languages
Spanish (es)
Other versions
ES2055652A1 (en
Inventor
Garcia Carolina Burgos
Ceinos M Luisa Izquierdo
Navio Jose Luis Garcia
Lopez Juan Jose Vaquero
Builla Gomez Julio Alvarez
Robisco Jose Luis Novella
Arinero Jose Calatayud
Jimenez Antonio Fernan Montoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECORDATI ELMU, S.L.
Original Assignee
ELMUQUIMICA FARM SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ELMUQUIMICA FARM SL filed Critical ELMUQUIMICA FARM SL
Priority to ES9201890A priority Critical patent/ES2055652B1/en
Publication of ES2055652A1 publication Critical patent/ES2055652A1/en
Application granted granted Critical
Publication of ES2055652B1 publication Critical patent/ES2055652B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)

Abstract

NUEVO PROCEDIMIENTO DE OBTENCION DE 2,6-DIMETIL-4-(2'', 3''-DICLOROFENIL)-1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METIL, VERIFICADO EN DOS ETAPAS. OBTENCION DEL 2-(2'',3''DICLORO) BENCILIDENACETOACETATO DE METILO A PARTIR DEL ACETOACETATO DE METILO Y EL 2,3-DICLOROBENZALDEHIDO EN PRESENCIA DE PIPERIDINA, ACIDO ACETICO GLACIAL E ISOPROPANOL. UN SEGUNDO PASO, DONDE SE TRATA CON 3-AMINOCROTONATO DE ETILO EN PRESENCIA DE ALUMINA ACTIVADA PARA DAR EL PRODUCTO TITULADO. VENTAJAS QUE SE OBTIENEN MEDIANTE ESTE PROCEDIMIENTO EN RELACION AL ESTADO ANTERIOR DE LA TECNICA: A) PROCESOS REALIZADOS EN CONDICIONES RAPIDAS, SUAVES Y SENCILLAS, OBTENIENDOSE PRODUCTOS DE ALTA CALIDAD. B) EL TIEMPO DE REACCION ES MENOR. C) EL ULTIMO PASO SE REALIZA EN FASE SOLIDA, EVITANDO TRAZAS DE DIHIDROPIRIDINAS SIMETRICAS. D) OBTENCION DE LA DIHIDROPIRIDINA SIN DISOLVENTE, MINIMA PRODUCCION DE EFLUENTES CONTAMINANTES. E) UTILIZACION DE CATALIZADORES BASICOS O ACIDOS RECICLABLES. F) BAJO COSTO DE LOS PROCESOS, MINIMIZACION DE REACTIVOS Y RESIDUOS. G) BAJO IMPACTO AMBIENTAL.NEW PROCEDURE FOR OBTAINING 2,6-DIMETHYL-4- (2``, 3 '' - DICHLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL, VERIFIED IN TWO STAGES. OBTAINING OF 2- (2``, 3''DICLORO) BENZLIDENACETOACETATO DE METHYL FROM METHYL ACETOACETATE AND 2,3-DICLOROBENZALDEHIDO IN THE PRESENCE OF PIPERIDINE, GLACIAL ACETIC ACID AND ISOPROPANOL. A SECOND STEP, WHERE IT IS TREATED WITH ETHYL 3-AMINOCROTONATE IN THE PRESENCE OF ACTIVATED ALUMINA TO GIVE THE TITLED PRODUCT. ADVANTAGES THAT ARE OBTAINED THROUGH THIS PROCEDURE IN RELATION TO THE PREVIOUS STATE OF THE TECHNIQUE: A) PROCESSES PERFORMED IN QUICK, SMOOTH AND SIMPLE CONDITIONS, OBTAINING HIGH QUALITY PRODUCTS. B) THE REACTION TIME IS LESS. C) THE LAST STEP IS PERFORMED IN THE SOLID PHASE, AVOIDING TRACES OF SYMMETRIC DIHYDROPYRIDINE. D) OBTAINING DIHYDROPIRIDINE WITHOUT SOLVENT, MINIMUM PRODUCTION OF CONTAMINANT EFFLUENTS. E) USE OF BASIC CATALYSTS OR RECYCLABLE ACIDS. F) LOW COST OF PROCESSES, MINIMIZATION OF REAGENTS AND WASTE. G) LOW ENVIRONMENTAL IMPACT.

ES9201890A 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. Expired - Fee Related ES2055652B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9201890A ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201890A ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Publications (2)

Publication Number Publication Date
ES2055652A1 ES2055652A1 (en) 1994-08-16
ES2055652B1 true ES2055652B1 (en) 1995-03-01

Family

ID=8278203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201890A Expired - Fee Related ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Country Status (1)

Country Link
ES (1) ES2055652B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101613280B (en) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
ES2177409B1 (en) * 2000-08-02 2003-08-01 Liconsa Liberacion Controlada PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
EP0311053A3 (en) * 1987-10-06 1991-05-08 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
IT1230752B (en) * 1989-02-17 1991-10-29 Boehringer Biochemia Srl PROCESS FOR THE PREPARATION OF 1,4 POLY-SUBSTITUTED DIHYDROPYRIDINS IN AN ANTIOMERICALLY PURE FORM.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101613280B (en) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate

Also Published As

Publication number Publication date
ES2055652A1 (en) 1994-08-16

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Date Code Title Description
PC2A Transfer granted

Owner name: RECORDATI ELMU, S.L.

FD1A Patent lapsed

Effective date: 20001204