ES2055652B1 - PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. - Google Patents
PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.Info
- Publication number
- ES2055652B1 ES2055652B1 ES9201890A ES9201890A ES2055652B1 ES 2055652 B1 ES2055652 B1 ES 2055652B1 ES 9201890 A ES9201890 A ES 9201890A ES 9201890 A ES9201890 A ES 9201890A ES 2055652 B1 ES2055652 B1 ES 2055652B1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- methyl
- procedure
- dihidropiridin
- dicarboxilato
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
NUEVO PROCEDIMIENTO DE OBTENCION DE 2,6-DIMETIL-4-(2'', 3''-DICLOROFENIL)-1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METIL, VERIFICADO EN DOS ETAPAS. OBTENCION DEL 2-(2'',3''DICLORO) BENCILIDENACETOACETATO DE METILO A PARTIR DEL ACETOACETATO DE METILO Y EL 2,3-DICLOROBENZALDEHIDO EN PRESENCIA DE PIPERIDINA, ACIDO ACETICO GLACIAL E ISOPROPANOL. UN SEGUNDO PASO, DONDE SE TRATA CON 3-AMINOCROTONATO DE ETILO EN PRESENCIA DE ALUMINA ACTIVADA PARA DAR EL PRODUCTO TITULADO. VENTAJAS QUE SE OBTIENEN MEDIANTE ESTE PROCEDIMIENTO EN RELACION AL ESTADO ANTERIOR DE LA TECNICA: A) PROCESOS REALIZADOS EN CONDICIONES RAPIDAS, SUAVES Y SENCILLAS, OBTENIENDOSE PRODUCTOS DE ALTA CALIDAD. B) EL TIEMPO DE REACCION ES MENOR. C) EL ULTIMO PASO SE REALIZA EN FASE SOLIDA, EVITANDO TRAZAS DE DIHIDROPIRIDINAS SIMETRICAS. D) OBTENCION DE LA DIHIDROPIRIDINA SIN DISOLVENTE, MINIMA PRODUCCION DE EFLUENTES CONTAMINANTES. E) UTILIZACION DE CATALIZADORES BASICOS O ACIDOS RECICLABLES. F) BAJO COSTO DE LOS PROCESOS, MINIMIZACION DE REACTIVOS Y RESIDUOS. G) BAJO IMPACTO AMBIENTAL.NEW PROCEDURE FOR OBTAINING 2,6-DIMETHYL-4- (2``, 3 '' - DICHLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL, VERIFIED IN TWO STAGES. OBTAINING OF 2- (2``, 3''DICLORO) BENZLIDENACETOACETATO DE METHYL FROM METHYL ACETOACETATE AND 2,3-DICLOROBENZALDEHIDO IN THE PRESENCE OF PIPERIDINE, GLACIAL ACETIC ACID AND ISOPROPANOL. A SECOND STEP, WHERE IT IS TREATED WITH ETHYL 3-AMINOCROTONATE IN THE PRESENCE OF ACTIVATED ALUMINA TO GIVE THE TITLED PRODUCT. ADVANTAGES THAT ARE OBTAINED THROUGH THIS PROCEDURE IN RELATION TO THE PREVIOUS STATE OF THE TECHNIQUE: A) PROCESSES PERFORMED IN QUICK, SMOOTH AND SIMPLE CONDITIONS, OBTAINING HIGH QUALITY PRODUCTS. B) THE REACTION TIME IS LESS. C) THE LAST STEP IS PERFORMED IN THE SOLID PHASE, AVOIDING TRACES OF SYMMETRIC DIHYDROPYRIDINE. D) OBTAINING DIHYDROPIRIDINE WITHOUT SOLVENT, MINIMUM PRODUCTION OF CONTAMINANT EFFLUENTS. E) USE OF BASIC CATALYSTS OR RECYCLABLE ACIDS. F) LOW COST OF PROCESSES, MINIMIZATION OF REAGENTS AND WASTE. G) LOW ENVIRONMENTAL IMPACT.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201890A ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201890A ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2055652A1 ES2055652A1 (en) | 1994-08-16 |
ES2055652B1 true ES2055652B1 (en) | 1995-03-01 |
Family
ID=8278203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9201890A Expired - Fee Related ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2055652B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613280B (en) * | 2009-05-13 | 2012-10-17 | 合肥立方制药股份有限公司 | Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
ES2177409B1 (en) * | 2000-08-02 | 2003-08-01 | Liconsa Liberacion Controlada | PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4780538A (en) * | 1986-02-12 | 1988-10-25 | Merck & Co., Inc. | Process for 1,4-dihydropyridine compounds using a titanamine catalyst |
EP0311053A3 (en) * | 1987-10-06 | 1991-05-08 | Banyu Pharmaceutical Co., Ltd. | Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use |
IT1230752B (en) * | 1989-02-17 | 1991-10-29 | Boehringer Biochemia Srl | PROCESS FOR THE PREPARATION OF 1,4 POLY-SUBSTITUTED DIHYDROPYRIDINS IN AN ANTIOMERICALLY PURE FORM. |
-
1992
- 1992-09-22 ES ES9201890A patent/ES2055652B1/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613280B (en) * | 2009-05-13 | 2012-10-17 | 合肥立方制药股份有限公司 | Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate |
Also Published As
Publication number | Publication date |
---|---|
ES2055652A1 (en) | 1994-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer granted |
Owner name: RECORDATI ELMU, S.L. |
|
FD1A | Patent lapsed |
Effective date: 20001204 |