ES2177409B1 - PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. - Google Patents

PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.

Info

Publication number
ES2177409B1
ES2177409B1 ES200001967A ES200001967A ES2177409B1 ES 2177409 B1 ES2177409 B1 ES 2177409B1 ES 200001967 A ES200001967 A ES 200001967A ES 200001967 A ES200001967 A ES 200001967A ES 2177409 B1 ES2177409 B1 ES 2177409B1
Authority
ES
Spain
Prior art keywords
hypertension
procedure
treatment
useful
dihydropiridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200001967A
Other languages
Spanish (es)
Other versions
ES2177409A1 (en
Inventor
Darder Carlos Picornell
Letelier Carlos Sunkel
Gomez Julio Alvarez-Builla
Cantera Jose Ignacio Lozano
Robisco Jose Luis Novella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liconsa SA
Original Assignee
Liconsa Liberacion Controlada de Sustancias Activas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liconsa Liberacion Controlada de Sustancias Activas SA filed Critical Liconsa Liberacion Controlada de Sustancias Activas SA
Priority to ES200001967A priority Critical patent/ES2177409B1/en
Publication of ES2177409A1 publication Critical patent/ES2177409A1/en
Application granted granted Critical
Publication of ES2177409B1 publication Critical patent/ES2177409B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Procedimiento para la obtención de 1,4-Dihidropiridinas substituidas útiles para el tratamiento de la hipertensión. El procedimiento se caracteriza por el hecho de que comprende la reacción entre un 2-metilidenacetoacetato de alquilo de fórmula V y un 3-aminocrotonato de alquilo de fórmula VI adsorbidos sobre una superficie sólida. Ventajosamente dicha superficie sólida es un agente poroso. El procedimiento comprende (a) adsorber dichos reactivos sobre dicho agente poroso mediante: (i) la disolución de dichos reactivos en un disolvente orgánico; (ii) la adición de dicho agente poroso; y (iii) la evaporación de dicho disolvente a sequedad; (b) calentar el sólido resultante de la etapa anterior; (c) extraer el producto; y (d) purificar el producto.Procedure for obtaining substituted 1,4-Dihydropyridines useful for the treatment of hypertension. The process is characterized by the fact that it comprises the reaction between an alkyl 2-methylidenacetoacetate of formula V and an alkyl 3-aminocrotonate of formula VI adsorbed on a solid surface. Advantageously said solid surface is a porous agent. The process comprises (a) adsorbing said reagents on said porous agent by: (i) dissolving said reagents in an organic solvent; (ii) the addition of said porous agent; and (iii) evaporation of said solvent to dryness; (b) heating the solid resulting from the previous stage; (c) extract the product; and (d) purify the product.

ES200001967A 2000-08-02 2000-08-02 PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. Expired - Fee Related ES2177409B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200001967A ES2177409B1 (en) 2000-08-02 2000-08-02 PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001967A ES2177409B1 (en) 2000-08-02 2000-08-02 PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.

Publications (2)

Publication Number Publication Date
ES2177409A1 ES2177409A1 (en) 2002-12-01
ES2177409B1 true ES2177409B1 (en) 2003-08-01

Family

ID=8494565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001967A Expired - Fee Related ES2177409B1 (en) 2000-08-02 2000-08-02 PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.

Country Status (1)

Country Link
ES (1) ES2177409B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975167A1 (en) 2007-03-30 2008-10-01 Esteve Quimica, S.A. Acetone solvate of phthaloyl amlodipine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000836A1 (en) * 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
ES2055652B1 (en) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.
ES2055655B1 (en) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ISOBUTIL-5-METHYL.

Also Published As

Publication number Publication date
ES2177409A1 (en) 2002-12-01

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