ES2177409B1 - PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. - Google Patents
PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION.Info
- Publication number
- ES2177409B1 ES2177409B1 ES200001967A ES200001967A ES2177409B1 ES 2177409 B1 ES2177409 B1 ES 2177409B1 ES 200001967 A ES200001967 A ES 200001967A ES 200001967 A ES200001967 A ES 200001967A ES 2177409 B1 ES2177409 B1 ES 2177409B1
- Authority
- ES
- Spain
- Prior art keywords
- hypertension
- procedure
- treatment
- useful
- dihydropiridines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Procedimiento para la obtención de 1,4-Dihidropiridinas substituidas útiles para el tratamiento de la hipertensión. El procedimiento se caracteriza por el hecho de que comprende la reacción entre un 2-metilidenacetoacetato de alquilo de fórmula V y un 3-aminocrotonato de alquilo de fórmula VI adsorbidos sobre una superficie sólida. Ventajosamente dicha superficie sólida es un agente poroso. El procedimiento comprende (a) adsorber dichos reactivos sobre dicho agente poroso mediante: (i) la disolución de dichos reactivos en un disolvente orgánico; (ii) la adición de dicho agente poroso; y (iii) la evaporación de dicho disolvente a sequedad; (b) calentar el sólido resultante de la etapa anterior; (c) extraer el producto; y (d) purificar el producto.Procedure for obtaining substituted 1,4-Dihydropyridines useful for the treatment of hypertension. The process is characterized by the fact that it comprises the reaction between an alkyl 2-methylidenacetoacetate of formula V and an alkyl 3-aminocrotonate of formula VI adsorbed on a solid surface. Advantageously said solid surface is a porous agent. The process comprises (a) adsorbing said reagents on said porous agent by: (i) dissolving said reagents in an organic solvent; (ii) the addition of said porous agent; and (iii) evaporation of said solvent to dryness; (b) heating the solid resulting from the previous stage; (c) extract the product; and (d) purify the product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001967A ES2177409B1 (en) | 2000-08-02 | 2000-08-02 | PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001967A ES2177409B1 (en) | 2000-08-02 | 2000-08-02 | PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2177409A1 ES2177409A1 (en) | 2002-12-01 |
ES2177409B1 true ES2177409B1 (en) | 2003-08-01 |
Family
ID=8494565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200001967A Expired - Fee Related ES2177409B1 (en) | 2000-08-02 | 2000-08-02 | PROCEDURE FOR OBTAINING SUBSTITUTED 1,4-DIHYDROPIRIDINES USEFUL FOR THE TREATMENT OF HYPERTENSION. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2177409B1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1975167A1 (en) | 2007-03-30 | 2008-10-01 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
ES2055652B1 (en) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
ES2055655B1 (en) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ISOBUTIL-5-METHYL. |
-
2000
- 2000-08-02 ES ES200001967A patent/ES2177409B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2177409A1 (en) | 2002-12-01 |
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Legal Events
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