ES2055654B1 - PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (3-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. - Google Patents
PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (3-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.Info
- Publication number
- ES2055654B1 ES2055654B1 ES9201892A ES9201892A ES2055654B1 ES 2055654 B1 ES2055654 B1 ES 2055654B1 ES 9201892 A ES9201892 A ES 9201892A ES 9201892 A ES9201892 A ES 9201892A ES 2055654 B1 ES2055654 B1 ES 2055654B1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- procedure
- dihidropiridin
- dicarboxilato
- etil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
NUEVO PROCEDIMIENTO DE OBTENCION DE 2,6-DIMETIL-4-(3''-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METIL, VERIFICADO EN DOS PASOS. OBTENCION DE 2-(3''-NITRO) BENCILIDENACETOACETATO DE ETILO A PARTIR DE 3-NITROBENZALDEHIDO Y ACETOACETATO DE ETILO EN PRESENCIA DE PIPERIDINA, ACIDO ACETICO GLACIAL E ISOPROPANOL, UN SEGUNDO PASO DONDE EL PRODUCTO ANTERIOR ES TRATADO CON 3-AMINOCROTONATO DE METILO EN PRESENCIA DE ALUMINA ACTIVADA, PARA RENDIR EL PRODUCTO TITULADO. VENTAJAS QUE SE OBTIENEN MEDIANTE ESTE PROCEDIMIENTO EN RELACION AL ESTADO ANTERIOR DE LA TECNICA: A) PROCESOS REALIZADOS EN CONDICIONES RAPIDAS, SUAVES Y SENCILLAS OBTENIENDOSE PRODUCTOS DE ALTA CALIDAD. B) EL ULTIMO PASO SE REALIZA EN FASE SOLIDA, EVITANDO TRAZAS DE DIHIDROPIRIDINAS SIMETRICAS. C) OBTENCION DE LA DIHIDROPIRIDINA SIN DISOLVENTE, MINIMA PRODUCCION DE EFLUENTES CONTAMINANTES. D) UTILIZACION DE CATALIZADORES BASICOS O ACIDOS RECICLABLES. E) BAJO COSTO EN LOS PROCESOS, MINIMIZACION DE REACTIVOS Y RESIDUOS.F) BAJO IMPACTO AMBIENTAL.NEW PROCEDURE FOR OBTAINING 2,6-DIMETHYL-4- (3 '' - NITROPHENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL, VERIFIED IN TWO STEPS. OBTAINING OF 2- (3 '' - NITRO) ETHYL BENZYLIDENACETOACETATE FROM 3-NITROBENZALDEHYDE AND ETHYL ACETOACETATE IN THE PRESENCE OF PIPERIDINE, GLACIAL ACETIC ACID, AND AROPYANE, AROUND 3-ELATE IN THE PRESENCE OF ACTIVATED ALUMINA, TO YIELD THE TITLED PRODUCT. ADVANTAGES THAT ARE OBTAINED THROUGH THIS PROCEDURE IN RELATION TO THE PREVIOUS STATE OF THE TECHNIQUE: A) PROCESSES PERFORMED IN QUICK, SMOOTH AND SIMPLE CONDITIONS OBTAINING HIGH QUALITY PRODUCTS. B) THE LAST STEP IS PERFORMED IN THE SOLID PHASE, AVOIDING TRACES OF SYMMETRIC DIHYDROPYRIDINE. C) OBTAINING DIHYDROPIRIDINE WITHOUT SOLVENT, MINIMUM PRODUCTION OF CONTAMINANT EFFLUENTS. D) USE OF BASIC CATALYSTS OR RECYCLABLE ACIDS. E) LOW COST IN THE PROCESSES, MINIMIZATION OF REAGENTS AND WASTE. F) LOW ENVIRONMENTAL IMPACT.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201892A ES2055654B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (3-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201892A ES2055654B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (3-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2055654A1 ES2055654A1 (en) | 1994-08-16 |
ES2055654B1 true ES2055654B1 (en) | 1995-03-01 |
Family
ID=8278207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9201892A Expired - Fee Related ES2055654B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (3-NITROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2055654B1 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4780538A (en) * | 1986-02-12 | 1988-10-25 | Merck & Co., Inc. | Process for 1,4-dihydropyridine compounds using a titanamine catalyst |
IT1230752B (en) * | 1989-02-17 | 1991-10-29 | Boehringer Biochemia Srl | PROCESS FOR THE PREPARATION OF 1,4 POLY-SUBSTITUTED DIHYDROPYRIDINS IN AN ANTIOMERICALLY PURE FORM. |
-
1992
- 1992-09-22 ES ES9201892A patent/ES2055654B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2055654A1 (en) | 1994-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer granted |
Owner name: BYK LEO LABORATORIO FARMACEUTICO, S.L. |
|
FD1A | Patent lapsed |
Effective date: 20060923 |