ES2055652A1 - Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate - Google Patents
Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylateInfo
- Publication number
- ES2055652A1 ES2055652A1 ES09201890A ES9201890A ES2055652A1 ES 2055652 A1 ES2055652 A1 ES 2055652A1 ES 09201890 A ES09201890 A ES 09201890A ES 9201890 A ES9201890 A ES 9201890A ES 2055652 A1 ES2055652 A1 ES 2055652A1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- methyl
- dihydropyridine
- ethyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
New procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl- 4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate, in two stages. The obtaining of methyl 2- (2',3'-dichloro)benzylideneacetoacetate from methyl acetoacetate and 2,3-dichlorobenzaldehyde in the presence of piperidine, glacial acetic acid and isopropanol. A second step in which it is treated with ethyl 3- aminocrotonate in the presence of activated alumina to give the title product. Advantages which are obtained by this procedure relative to the prior art: a) Processes carried out under rapid, smooth and simple conditions, giving products of high quality. b) The reaction time is less. c) The last step is carried out in a solid phase, avoiding traces of symmetrical dihydropyridines. d) Obtaining of the dihydropyridine without a solvent, minimum production of contaminating effluent. e) Use of recyclable basic or acid catalysts. f) Low cost of the processes, minimization of reagents and residues. g) Low environmental impact.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201890A ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9201890A ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2055652A1 true ES2055652A1 (en) | 1994-08-16 |
ES2055652B1 ES2055652B1 (en) | 1995-03-01 |
Family
ID=8278203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9201890A Expired - Fee Related ES2055652B1 (en) | 1992-09-22 | 1992-09-22 | PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2055652B1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1089974A4 (en) * | 1995-12-28 | 2001-05-30 | Hoechst Celanese Corp | Process to prepare dihydropyridine and derivatives thereof |
ES2177409A1 (en) * | 2000-08-02 | 2002-12-01 | Liconsa Liberacion Controlada | Production of pyridine derivatives, useful for hypertension treatment, comprises reaction of an acetoacetate with an amino crotonate, for solvent treatment and evaporation |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613280B (en) * | 2009-05-13 | 2012-10-17 | 合肥立方制药股份有限公司 | Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0234776A2 (en) * | 1986-02-12 | 1987-09-02 | Merck & Co. Inc. | Process for 1,4-dihydropyridine compounds |
EP0311053A2 (en) * | 1987-10-06 | 1989-04-12 | Banyu Pharmaceutical Co., Ltd. | Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use |
EP0383320A1 (en) * | 1989-02-17 | 1990-08-22 | Boehringer Mannheim Italia S.P.A. | A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines |
-
1992
- 1992-09-22 ES ES9201890A patent/ES2055652B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0234776A2 (en) * | 1986-02-12 | 1987-09-02 | Merck & Co. Inc. | Process for 1,4-dihydropyridine compounds |
EP0311053A2 (en) * | 1987-10-06 | 1989-04-12 | Banyu Pharmaceutical Co., Ltd. | Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use |
EP0383320A1 (en) * | 1989-02-17 | 1990-08-22 | Boehringer Mannheim Italia S.P.A. | A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1089974A4 (en) * | 1995-12-28 | 2001-05-30 | Hoechst Celanese Corp | Process to prepare dihydropyridine and derivatives thereof |
ES2177409A1 (en) * | 2000-08-02 | 2002-12-01 | Liconsa Liberacion Controlada | Production of pyridine derivatives, useful for hypertension treatment, comprises reaction of an acetoacetate with an amino crotonate, for solvent treatment and evaporation |
Also Published As
Publication number | Publication date |
---|---|
ES2055652B1 (en) | 1995-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO963991D0 (en) | Process of Separation of Enantiomers of Amlodipine via Their Diastereomeric Tartrates | |
DE69218330D1 (en) | Process for the preparation of 1,4-dihydropyridines substituted at the 4-position | |
ES2055652A1 (en) | Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate | |
CA2217849A1 (en) | A process for the preparation of lercanidipine hydrochloride | |
ATE242255T1 (en) | SYNTHESIS OF FATTY ACID POLYESTERS FROM POLYOLS USING AN INERT GAS REMOVAL COLUMN | |
MXPA04004063A (en) | Processes for the manufacturing of 3-hydroxy -n, 1, 6-trialkyl -4-oxo-1, 4-dihydropyridine -2-carboxamide. | |
ES2055654A1 (en) | Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | |
DE69519779T2 (en) | Process for the preparation of N-oxyl hindered amine esters using tetraalkyl orthotitanate transesterification catalysts | |
ES2055653A1 (en) | Procedure for obtaining 3-isopropyl-5-(2'-methoxy)ethyl 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylate | |
ES2055655A1 (en) | Procedure for obtaining 3-isobutyl-5-methyl 2,6-dimethyl- 4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | |
CA2425561A1 (en) | Process to prepare 1,4-dihydropyridine intermediates and derivatives thereof | |
MY116842A (en) | Manufacturing process for felopipine | |
US3483210A (en) | Catalyzed oxidative conversion of amine methyl groups to amine formyl groups | |
US5728836A (en) | Process for preparing 4-acylamino-2,2,6,6-tetramethylpiperidines | |
WO2002020481A3 (en) | Substituted 4-phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine | |
DE59107618D1 (en) | Process for the preparation of ethylene-alkylcarboxylic acid vinyl ester copolymers | |
DE60223003D1 (en) | PROCESS FOR PREPARING AMLODIPIN | |
DE3673064D1 (en) | METHOD FOR PRODUCING 2,6-DIMETHYL-4- (3'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-3,5-DICARBONIC ACID-3 BETA- (N-BENZYL-N-METHYLAMINO) -ETHYLESTERES-5-METHYLESTER AND WHOSE HYDROCHLORIDE SALT. | |
ES2012687A6 (en) | Process for the preparation of 1,4-dihydro-pyridine derivatives | |
PT1532110E (en) | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | |
KR930016399A (en) | Certain 1,4-dihydropyridine-3,5-dicarboxylic acid esters, methods for their preparation and pharmaceutical uses thereof | |
US6015906A (en) | Dimethylamine benzoate or p-anisate catalysed process for the preparation of 4-(nitrophenyl)-dihydropyridines | |
HUT49323A (en) | Process for producing azometin derivatives | |
EP0245680A3 (en) | A process for the preparation of 2-(n-benzyl-n-methylamino)-ethyl-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate hydrochloride | |
ATE148896T1 (en) | METHOD FOR PRODUCING GLURATIMIDE COPOLYMERS AND INTERMEDIATE PRODUCTS THEREFOR |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent |
Owner name: RECORDATI ELMU, S.L. |
|
FD1A | Patent lapsed |
Effective date: 20001204 |