ES2055652A1 - Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate - Google Patents

Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate

Info

Publication number
ES2055652A1
ES2055652A1 ES09201890A ES9201890A ES2055652A1 ES 2055652 A1 ES2055652 A1 ES 2055652A1 ES 09201890 A ES09201890 A ES 09201890A ES 9201890 A ES9201890 A ES 9201890A ES 2055652 A1 ES2055652 A1 ES 2055652A1
Authority
ES
Spain
Prior art keywords
obtaining
methyl
dihydropyridine
ethyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09201890A
Other languages
Spanish (es)
Other versions
ES2055652B1 (en
Inventor
Garcia Carolina Burgos
Ceinos M Luisa Izquierdo
Navio Jose Luis Garcia
Lopez Juan Jose Vaquero
Builla Gomez Julio Alvarez
Robisco Jose Luis Novella
Arinero Jose Calatayud
Jimenez Antonio Fernan Montoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECORDATI ELMU, S.L.
Original Assignee
ELMUQUIMICA FARM SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ELMUQUIMICA FARM SL filed Critical ELMUQUIMICA FARM SL
Priority to ES9201890A priority Critical patent/ES2055652B1/en
Publication of ES2055652A1 publication Critical patent/ES2055652A1/en
Application granted granted Critical
Publication of ES2055652B1 publication Critical patent/ES2055652B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

New procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl- 4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate, in two stages. The obtaining of methyl 2- (2',3'-dichloro)benzylideneacetoacetate from methyl acetoacetate and 2,3-dichlorobenzaldehyde in the presence of piperidine, glacial acetic acid and isopropanol. A second step in which it is treated with ethyl 3- aminocrotonate in the presence of activated alumina to give the title product. Advantages which are obtained by this procedure relative to the prior art: a) Processes carried out under rapid, smooth and simple conditions, giving products of high quality. b) The reaction time is less. c) The last step is carried out in a solid phase, avoiding traces of symmetrical dihydropyridines. d) Obtaining of the dihydropyridine without a solvent, minimum production of contaminating effluent. e) Use of recyclable basic or acid catalysts. f) Low cost of the processes, minimization of reagents and residues. g) Low environmental impact.
ES9201890A 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL. Expired - Fee Related ES2055652B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9201890A ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201890A ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Publications (2)

Publication Number Publication Date
ES2055652A1 true ES2055652A1 (en) 1994-08-16
ES2055652B1 ES2055652B1 (en) 1995-03-01

Family

ID=8278203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201890A Expired - Fee Related ES2055652B1 (en) 1992-09-22 1992-09-22 PROCEDURE FOR OBTAINING 2,6-DIMETIL-4- (2,3-DICLOROFENIL) -1,4-DIHIDROPIRIDIN-3,5-DICARBOXILATO DE 3-ETIL-5-METHYL.

Country Status (1)

Country Link
ES (1) ES2055652B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1089974A4 (en) * 1995-12-28 2001-05-30 Hoechst Celanese Corp Process to prepare dihydropyridine and derivatives thereof
ES2177409A1 (en) * 2000-08-02 2002-12-01 Liconsa Liberacion Controlada Production of pyridine derivatives, useful for hypertension treatment, comprises reaction of an acetoacetate with an amino crotonate, for solvent treatment and evaporation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101613280B (en) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 Preparation method of felodipine synthetic intermediate methyl 2-(2,3-dichlorobenzylidine)acetoacetate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0311053A2 (en) * 1987-10-06 1989-04-12 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0311053A2 (en) * 1987-10-06 1989-04-12 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1089974A4 (en) * 1995-12-28 2001-05-30 Hoechst Celanese Corp Process to prepare dihydropyridine and derivatives thereof
ES2177409A1 (en) * 2000-08-02 2002-12-01 Liconsa Liberacion Controlada Production of pyridine derivatives, useful for hypertension treatment, comprises reaction of an acetoacetate with an amino crotonate, for solvent treatment and evaporation

Also Published As

Publication number Publication date
ES2055652B1 (en) 1995-03-01

Similar Documents

Publication Publication Date Title
NO963991D0 (en) Process of Separation of Enantiomers of Amlodipine via Their Diastereomeric Tartrates
DE69218330D1 (en) Process for the preparation of 1,4-dihydropyridines substituted at the 4-position
ES2055652A1 (en) Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5- dicarboxylate
CA2217849A1 (en) A process for the preparation of lercanidipine hydrochloride
ATE242255T1 (en) SYNTHESIS OF FATTY ACID POLYESTERS FROM POLYOLS USING AN INERT GAS REMOVAL COLUMN
MXPA04004063A (en) Processes for the manufacturing of 3-hydroxy -n, 1, 6-trialkyl -4-oxo-1, 4-dihydropyridine -2-carboxamide.
ES2055654A1 (en) Procedure for obtaining 3-ethyl-5-methyl 2,6-dimethyl-4- (3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
DE69519779T2 (en) Process for the preparation of N-oxyl hindered amine esters using tetraalkyl orthotitanate transesterification catalysts
ES2055653A1 (en) Procedure for obtaining 3-isopropyl-5-(2'-methoxy)ethyl 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylate
ES2055655A1 (en) Procedure for obtaining 3-isobutyl-5-methyl 2,6-dimethyl- 4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CA2425561A1 (en) Process to prepare 1,4-dihydropyridine intermediates and derivatives thereof
MY116842A (en) Manufacturing process for felopipine
US3483210A (en) Catalyzed oxidative conversion of amine methyl groups to amine formyl groups
US5728836A (en) Process for preparing 4-acylamino-2,2,6,6-tetramethylpiperidines
WO2002020481A3 (en) Substituted 4-phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
DE59107618D1 (en) Process for the preparation of ethylene-alkylcarboxylic acid vinyl ester copolymers
DE60223003D1 (en) PROCESS FOR PREPARING AMLODIPIN
DE3673064D1 (en) METHOD FOR PRODUCING 2,6-DIMETHYL-4- (3'-NITROPHENYL) -1,4-DIHYDROPYRIDINE-3,5-DICARBONIC ACID-3 BETA- (N-BENZYL-N-METHYLAMINO) -ETHYLESTERES-5-METHYLESTER AND WHOSE HYDROCHLORIDE SALT.
ES2012687A6 (en) Process for the preparation of 1,4-dihydro-pyridine derivatives
PT1532110E (en) Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine)
KR930016399A (en) Certain 1,4-dihydropyridine-3,5-dicarboxylic acid esters, methods for their preparation and pharmaceutical uses thereof
US6015906A (en) Dimethylamine benzoate or p-anisate catalysed process for the preparation of 4-(nitrophenyl)-dihydropyridines
HUT49323A (en) Process for producing azometin derivatives
EP0245680A3 (en) A process for the preparation of 2-(n-benzyl-n-methylamino)-ethyl-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate hydrochloride
ATE148896T1 (en) METHOD FOR PRODUCING GLURATIMIDE COPOLYMERS AND INTERMEDIATE PRODUCTS THEREFOR

Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: RECORDATI ELMU, S.L.

FD1A Patent lapsed

Effective date: 20001204