ES2054327T3 - Sintesis de derivados de manojirimicina. - Google Patents
Sintesis de derivados de manojirimicina.Info
- Publication number
- ES2054327T3 ES2054327T3 ES90870141T ES90870141T ES2054327T3 ES 2054327 T3 ES2054327 T3 ES 2054327T3 ES 90870141 T ES90870141 T ES 90870141T ES 90870141 T ES90870141 T ES 90870141T ES 2054327 T3 ES2054327 T3 ES 2054327T3
- Authority
- ES
- Spain
- Prior art keywords
- homomannojirimycin
- epi
- configuration
- alpha
- manojirimicina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- CLVUFWXGNIFGNC-KVTDHHQDSA-N (2r,3r,5r,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol Chemical compound OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O CLVUFWXGNIFGNC-KVTDHHQDSA-N 0.000 abstract 3
- CLVUFWXGNIFGNC-UHFFFAOYSA-N alpha-homonojirimycin Natural products OCC1NC(CO)C(O)C(O)C1O CLVUFWXGNIFGNC-UHFFFAOYSA-N 0.000 abstract 2
- BUBVLQDEIIUIQG-UHFFFAOYSA-N 3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-one Chemical compound C=1C=CC=CC=1COC1C(OCC=2C=CC=CC=2)C(OCC=2C=CC=CC=2)C(=O)OC1COCC1=CC=CC=C1 BUBVLQDEIIUIQG-UHFFFAOYSA-N 0.000 abstract 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
(ALFA)-HOMOMANOJIRIMICINA (1) Y 6-EPI-HOMOMANOJIRIMICINA (2) SON CADA UNA SINTETIZADAS DEL 2-AZIDO-2-DEOXI-3,4:6,7-DI-O-ISOPROPILIDENO-D-GLICERO-DTALO-HEPTONO-1,5-LACTONA (3) EN LA CUAL LA CADENA DE ACETONIDA LATERAL SE HIDROLIZA PARA DAR EL DIOL CORRESPONDIENTE QUE SERA ENTONCES PROTEGIDO CON UN AGENTE PROTECTOR SILIL PARA FORMAR UN ETER SILIL. EL ULTIMO COMPUESTO SE UTILIZA COMO UN INTERMEDIARIO DIVERGENTE EN EL QUE SE FORMA EL ANILLO DE PIPERIDINA UNIENDO LA FUNCION DEL NITROGENO CON C-02 A C-6 (A) CON INVERSION DE LA CONFIGURACION EN C-6 PARA FORMAR 6-EPI-HOMOMANOJIRIMICINA O (B) CON RETENCION DE LA CONFIGURACION EN C-6 PARA FORMAR (ALFA)HOMOMANOJIRIMICINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/419,806 US5011929A (en) | 1989-05-15 | 1989-10-11 | Synthesis of mannojirimycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2054327T3 true ES2054327T3 (es) | 1994-08-01 |
Family
ID=23663839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90870141T Expired - Lifetime ES2054327T3 (es) | 1989-10-11 | 1990-09-04 | Sintesis de derivados de manojirimicina. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5011929A (es) |
| EP (1) | EP0427694B1 (es) |
| JP (1) | JP2942606B2 (es) |
| AT (1) | ATE105283T1 (es) |
| CA (1) | CA2024843C (es) |
| DE (1) | DE69008668T2 (es) |
| DK (1) | DK0427694T3 (es) |
| ES (1) | ES2054327T3 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210089A (en) * | 1992-02-04 | 1993-05-11 | Monsanto Company | D-rhamnono-1,5-lactone |
| US5250703A (en) * | 1992-09-29 | 1993-10-05 | Monsanto Company | Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof |
| ATE382351T1 (de) | 1999-08-10 | 2008-01-15 | Univ Oxford | Langkettige n-alkyl verbindungen und deren oxa- derivate zur verwendung als anitvirale mittel |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| KR100665194B1 (ko) * | 2005-08-30 | 2007-01-04 | 주식회사 한림전자 | 전자부품 솔더용 고정홀더 |
| EP2399587A1 (en) | 2006-08-02 | 2011-12-28 | The University of Oxford | Liposome treatment of viral infections |
| CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| EP2282723A2 (en) * | 2008-03-26 | 2011-02-16 | University of Oxford | Endoplasmic reticulum targeting liposomes |
| EP2410989A2 (en) * | 2009-03-27 | 2012-02-01 | The Chancellor, Masters and Scholars of the University of Oxford | Cholesterol level lowering liposomes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3024901A1 (de) * | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| US4357360A (en) * | 1980-11-13 | 1982-11-02 | International Flavors & Fragrances Inc. | Use of tricyclic alcohols, ethers and esters for augmenting or enhancing the aroma or taste of foodstuffs |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
-
1989
- 1989-10-11 US US07/419,806 patent/US5011929A/en not_active Expired - Lifetime
-
1990
- 1990-09-04 AT AT9090870141T patent/ATE105283T1/de not_active IP Right Cessation
- 1990-09-04 EP EP90870141A patent/EP0427694B1/en not_active Expired - Lifetime
- 1990-09-04 ES ES90870141T patent/ES2054327T3/es not_active Expired - Lifetime
- 1990-09-04 DE DE69008668T patent/DE69008668T2/de not_active Expired - Fee Related
- 1990-09-04 DK DK90870141.0T patent/DK0427694T3/da active
- 1990-09-07 CA CA002024843A patent/CA2024843C/en not_active Expired - Fee Related
- 1990-09-07 JP JP2238863A patent/JP2942606B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0427694B1 (en) | 1994-05-04 |
| DK0427694T3 (da) | 1994-06-13 |
| EP0427694A1 (en) | 1991-05-15 |
| CA2024843C (en) | 2001-11-20 |
| DE69008668T2 (de) | 1994-11-24 |
| JP2942606B2 (ja) | 1999-08-30 |
| JPH03127775A (ja) | 1991-05-30 |
| CA2024843A1 (en) | 1991-04-12 |
| US5011929A (en) | 1991-04-30 |
| DE69008668D1 (de) | 1994-06-09 |
| ATE105283T1 (de) | 1994-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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