ES2053872T3 - Derivados de fibrina o fibrinogeno, procedimiento para su preparacion y su empleo. - Google Patents

Derivados de fibrina o fibrinogeno, procedimiento para su preparacion y su empleo.

Info

Publication number
ES2053872T3
ES2053872T3 ES89110250T ES89110250T ES2053872T3 ES 2053872 T3 ES2053872 T3 ES 2053872T3 ES 89110250 T ES89110250 T ES 89110250T ES 89110250 T ES89110250 T ES 89110250T ES 2053872 T3 ES2053872 T3 ES 2053872T3
Authority
ES
Spain
Prior art keywords
fibrin
fibrinogen
derivatives
employment
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89110250T
Other languages
English (en)
Inventor
Thomas Dr Stief
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2053872T3 publication Critical patent/ES2053872T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen

Abstract

SE DESCRIBEN DERIVADOS OXIDADOS DE FIBRINA O DE PRODUCTOS DE ESCISION DE FIBRINA O FIBRINOGENO O SECUENCIAS PARCIALES DE LOS MISMOS. TAMBIEN SE DESCRIBEN PROCESOS PARA SU OBTENCION, ASI COMO SU USO COMO MEDICAMENTOS PARA DIAGNOSIS O COMO AGENTE AFIN.
ES89110250T 1988-06-11 1989-06-07 Derivados de fibrina o fibrinogeno, procedimiento para su preparacion y su empleo. Expired - Lifetime ES2053872T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3819923A DE3819923A1 (de) 1988-06-11 1988-06-11 Fibrin(ogen)derivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2053872T3 true ES2053872T3 (es) 1994-08-01

Family

ID=6356348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89110250T Expired - Lifetime ES2053872T3 (es) 1988-06-11 1989-06-07 Derivados de fibrina o fibrinogeno, procedimiento para su preparacion y su empleo.

Country Status (7)

Country Link
US (2) US5376631A (es)
EP (1) EP0346741B1 (es)
JP (1) JPH0236200A (es)
AT (1) ATE85623T1 (es)
AU (1) AU621373B2 (es)
DE (2) DE3819923A1 (es)
ES (1) ES2053872T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5473051A (en) * 1990-07-19 1995-12-05 The Scripps Research Institute Inhibition of Mac-1 receptor binding to fibrinogen using D30 homologs
AU644205B2 (en) * 1990-08-23 1993-12-02 New York Blood Center, Inc., The Assays using a soluble fibrin-like monomer
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
EP1130031A1 (en) * 2000-02-25 2001-09-05 Universitair Medisch Centrum Utrecht Method for inhibiting angiogenesis using molecules that enhance plasmin formation or prolong plasmin activity
CA2453140C (en) * 2000-10-20 2016-01-05 Hamburger Stiftung Zur Forderung Von Wissenschaft Und Kultur Oxidized proteins, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechanism, from the use of these proteins and from the inhibition thereof
JP6042106B2 (ja) * 2011-06-10 2016-12-14 株式会社ファンペップ メチオニン・スルホキシドを含む新規ポリペプチド
WO2016159050A1 (ja) * 2015-03-30 2016-10-06 国立大学法人神戸大学 血液試料中のアンバウンドビリルビンの測定方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979506A (en) * 1974-10-11 1976-09-07 Pierce Chemical Company Radioactive compounds for labeling proteins
US4455290A (en) * 1981-04-02 1984-06-19 Research Corporation Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
DE3722082A1 (de) * 1987-07-03 1989-01-12 Behringwerke Ag Verfahren zur bestimmung der aktivitaet von serinproteasen oder serinproteaseinhibitoren

Also Published As

Publication number Publication date
AU3619389A (en) 1989-12-14
EP0346741A3 (en) 1990-05-16
US5376631A (en) 1994-12-27
US5427918A (en) 1995-06-27
EP0346741A2 (de) 1989-12-20
EP0346741B1 (de) 1993-02-10
JPH0236200A (ja) 1990-02-06
AU621373B2 (en) 1992-03-12
ATE85623T1 (de) 1993-02-15
DE3819923A1 (de) 1989-12-21
DE58903500D1 (de) 1993-03-25

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