ES2052826T3 - Procedimiento de resolucion enzimatica. - Google Patents

Procedimiento de resolucion enzimatica.

Info

Publication number
ES2052826T3
ES2052826T3 ES89112464T ES89112464T ES2052826T3 ES 2052826 T3 ES2052826 T3 ES 2052826T3 ES 89112464 T ES89112464 T ES 89112464T ES 89112464 T ES89112464 T ES 89112464T ES 2052826 T3 ES2052826 T3 ES 2052826T3
Authority
ES
Spain
Prior art keywords
resolution procedure
enzymatic resolution
compounds
formula
encymatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89112464T
Other languages
English (en)
Inventor
Jeffrey M Howell
Ramesh N Patel
Lazlo J Szarka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2052826T3 publication Critical patent/ES2052826T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCUBRE UN NUEVO PROCESO DE DESCOMPOSICION ENCIMATICA PARA PREPARAR COMPUESTOS REDUCIDOS DE LA FORMULA CON RENDIMIENTO MEJORADO Y ALTA PUREZA OPTICA. COMPUESTOS DE FORMULA I'' SE USAN, POR EJEMPLO, COMO INTERMEDIOS PARA LA PREPARACION DE COMPUESTOS PSICOLOGICAMENTE ACTIVOS, P.EJ. CAPTOPRIL (C9H15NO3S).
ES89112464T 1988-07-14 1989-07-07 Procedimiento de resolucion enzimatica. Expired - Lifetime ES2052826T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21962488A 1988-07-14 1988-07-14

Publications (1)

Publication Number Publication Date
ES2052826T3 true ES2052826T3 (es) 1994-07-16

Family

ID=22820042

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89112464T Expired - Lifetime ES2052826T3 (es) 1988-07-14 1989-07-07 Procedimiento de resolucion enzimatica.

Country Status (6)

Country Link
EP (1) EP0350811B1 (es)
JP (1) JP2769194B2 (es)
CA (1) CA1318627C (es)
DE (1) DE68915350T2 (es)
ES (1) ES2052826T3 (es)
IE (1) IE64487B1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5728575A (en) 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
EP0538693A3 (en) * 1991-10-23 1994-08-17 Squibb & Sons Inc Stereoselective preparation of halophenyl alcohols
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5420337A (en) * 1992-11-12 1995-05-30 E. R. Squibb & Sons, Inc. Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
ES2120881B1 (es) * 1996-02-05 1999-11-16 Dsm Deretil S A Enantiomeros de 5-metil-1, 3-tiazin-2, 4-diona y su empleo en la sintesis de intermedios de farmacos quirales.
AU4250501A (en) * 2000-04-06 2001-10-23 Societe Des Produits Nestle S.A. Preparation of thiols and derivatives by bio-conversion

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130752B1 (en) * 1983-07-04 1991-02-27 Mitsubishi Rayon Co., Ltd. Process for preparing optically active carboxylic acids and antipode esters thereof
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
EP0259465A1 (en) * 1986-03-07 1988-03-16 Wisconsin Alumni Research Foundation Process for preparing optically-active 3-acylthio-2-methylpropionic acid derivatives
DE3740165A1 (de) * 1986-11-27 1988-06-09 Sumitomo Chemical Co Verfahren zur herstellung von hydroxycyclopentenonen

Also Published As

Publication number Publication date
JPH0260599A (ja) 1990-03-01
DE68915350T2 (de) 1994-08-25
EP0350811A3 (en) 1991-04-10
JP2769194B2 (ja) 1998-06-25
DE68915350D1 (de) 1994-06-23
EP0350811A2 (en) 1990-01-17
CA1318627C (en) 1993-06-01
IE64487B1 (en) 1995-08-09
EP0350811B1 (en) 1994-05-18
IE892110L (en) 1990-01-14

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