ES2052617T3 - Emulsion de producto quimico fluorado oxigenado para uso en el tratamiento de radiacion de celulas tumorales hipoxicas de mamiferos. - Google Patents

Emulsion de producto quimico fluorado oxigenado para uso en el tratamiento de radiacion de celulas tumorales hipoxicas de mamiferos.

Info

Publication number
ES2052617T3
ES2052617T3 ES88102097T ES88102097T ES2052617T3 ES 2052617 T3 ES2052617 T3 ES 2052617T3 ES 88102097 T ES88102097 T ES 88102097T ES 88102097 T ES88102097 T ES 88102097T ES 2052617 T3 ES2052617 T3 ES 2052617T3
Authority
ES
Spain
Prior art keywords
oxygenated
mammals
emulsion
radiation treatment
tumor cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88102097T
Other languages
English (en)
Spanish (es)
Inventor
Frank Kenneth Schweighardt
David W Woo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Products and Chemicals Inc
Original Assignee
Air Products and Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Products and Chemicals Inc filed Critical Air Products and Chemicals Inc
Application granted granted Critical
Publication of ES2052617T3 publication Critical patent/ES2052617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Radiation-Therapy Devices (AREA)
ES88102097T 1987-02-20 1988-02-12 Emulsion de producto quimico fluorado oxigenado para uso en el tratamiento de radiacion de celulas tumorales hipoxicas de mamiferos. Expired - Lifetime ES2052617T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/016,812 US4781676A (en) 1987-02-20 1987-02-20 Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells

Publications (1)

Publication Number Publication Date
ES2052617T3 true ES2052617T3 (es) 1994-07-16

Family

ID=21779122

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88102097T Expired - Lifetime ES2052617T3 (es) 1987-02-20 1988-02-12 Emulsion de producto quimico fluorado oxigenado para uso en el tratamiento de radiacion de celulas tumorales hipoxicas de mamiferos.

Country Status (9)

Country Link
US (1) US4781676A (enExample)
EP (1) EP0279379B1 (enExample)
JP (1) JPS63222114A (enExample)
KR (1) KR880009642A (enExample)
CA (1) CA1311420C (enExample)
DE (1) DE3875629T2 (enExample)
ES (1) ES2052617T3 (enExample)
MX (1) MX168608B (enExample)
ZA (1) ZA881184B (enExample)

Families Citing this family (42)

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Publication number Priority date Publication date Assignee Title
US4931472A (en) * 1985-09-17 1990-06-05 Biomed Technology, Inc. Fluorinated triethylenediamine as an oxygen transport agent
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4989601A (en) * 1988-05-02 1991-02-05 Medical Engineering & Development Institute, Inc. Method, apparatus, and substance for treating tissue having neoplastic cells
US4951673A (en) * 1988-08-19 1990-08-28 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
WO1990011082A1 (de) * 1989-03-17 1990-10-04 Buchholz Klaus L Verwendung eines reaktionsproduktes aus einem gas und einer flüssigkeit, sowie verfahren und vorrichtung zu seiner herstellung
WO1992005792A1 (de) * 1990-10-02 1992-04-16 Buchholz Klaus L Verwendung eines reaktionsproduktes aus einem gas und einer flüssigkeit, sowie verfahren und vorrichtung zu seiner herstellung
US5146014A (en) * 1991-07-02 1992-09-08 Air Products And Chemicals, Inc. Perfluoroethyldimethyl cyclohexane
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5350359A (en) * 1992-07-16 1994-09-27 Temple University Of The Commonwealth System Of Higher Education Control, treatment and/or diagnosis of physiological conditions with degassed perfluorocarbon liquid
US5257979A (en) * 1992-07-27 1993-11-02 Ravindar Jagpal Instrument for catheterization
US5335650A (en) * 1992-10-13 1994-08-09 Temple University - Of The Commonwealth System Of Higher Education Process control for liquid ventilation and related procedures
JP3559849B2 (ja) 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US5695479A (en) * 1993-11-01 1997-12-09 Jagpal; Ravindar Instrument, system, kit and method for catheterization procedures
RU2088223C1 (ru) * 1994-06-29 1997-08-27 Игорь Вячеславович Белов Антиметастатическое средство
US5608520A (en) * 1994-07-11 1997-03-04 The United States Of America As Represented By He Department Of Energy Plasma emission spectroscopy method of tumor therapy
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5590651A (en) * 1995-01-17 1997-01-07 Temple University - Of The Commonwealth System Of Higher Education Breathable liquid elimination analysis
US5726209A (en) * 1995-06-07 1998-03-10 Alliance Pharmaceutical Corp. Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir
US5741248A (en) * 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
US7008535B1 (en) 2000-08-04 2006-03-07 Wayne State University Apparatus for oxygenating wastewater
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US8308682B2 (en) 2003-07-18 2012-11-13 Broncus Medical Inc. Devices for maintaining patency of surgically created channels in tissue
US8409167B2 (en) 2004-07-19 2013-04-02 Broncus Medical Inc Devices for delivering substances through an extra-anatomic opening created in an airway
US7648487B2 (en) * 2004-09-28 2010-01-19 Nipro Corporation Syringe
GB2422310B (en) * 2004-12-02 2006-12-27 Kaizen Matsumoto Carcinogen solvents in reducing the carcinogen concentration of cells
KR101315904B1 (ko) 2005-02-24 2013-10-08 디퓨젼 파마슈티컬즈 엘엘씨 트랜스 카로티노이드, 이들의 합성, 제제화 및 용도
MX2009010988A (es) 2007-04-13 2010-03-15 Diffusion Pharmaceuticals Llc Uso de trans-carotenoides bipolares como un tratamiento previo y en el tratamiento de una enfermedad vascular periferica.
EP3539542B1 (en) 2009-06-22 2023-04-19 Diffusion Pharmaceuticals LLC Diffusion enhancing compounds and their use with a thrombolytic
EP2575487B1 (en) 2010-06-02 2017-10-18 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
US9351943B2 (en) * 2010-07-01 2016-05-31 Matthew T. McLeay Anti-fibroblastic fluorochemical emulsion therapies
US8709034B2 (en) 2011-05-13 2014-04-29 Broncus Medical Inc. Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
US9345532B2 (en) 2011-05-13 2016-05-24 Broncus Medical Inc. Methods and devices for ablation of tissue
WO2013078235A1 (en) 2011-11-23 2013-05-30 Broncus Medical Inc Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall
JP7032320B2 (ja) 2016-03-24 2022-03-08 ディフュージョン・ファーマシューティカルズ・エルエルシー 癌を処置するための、化学療法及び放射線療法を伴う二極性トランスカロテノイドの使用
WO2017201089A1 (en) 2016-05-16 2017-11-23 Mtm Research, Llc Fluorochemical targeted therapies
US11760991B2 (en) 2018-04-12 2023-09-19 The University Of Akron Multi-functional oxygenating microparticle loaded cell aggregates
US12239707B2 (en) 2018-05-07 2025-03-04 Mt Research, Llc Photodynamic compositions and methods of use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823091A (en) * 1971-05-19 1974-07-09 Green Cross Corp Stable emulsion of fluorocarbon particles
JPS5331209B2 (enExample) * 1973-10-05 1978-09-01
GB1577969A (en) * 1976-02-26 1980-10-29 Tsutsumi M Surgical or medical instrument of the injector type
GB2006381B (en) * 1977-08-18 1982-05-06 Osaka Gas Co Ltd Method of internally lining an installed pipe
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4558690A (en) * 1982-01-26 1985-12-17 University Of Scranton Method of administration of chemotherapy to tumors
JPS58159409A (ja) * 1982-03-03 1983-09-21 サンテツク・インコポレイテツド 傷の治療剤としてのペルフルオロカ−ボンの使用
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
US4742050B1 (en) * 1982-08-17 1994-06-28 Alpha Therapeutic Corp Sensitization of hypoxic tumor cells and control of growth thereof
CH665952A5 (de) * 1982-08-17 1988-06-30 Sun Tech Inc Cyclische perfluorverbindungen enthaltende waessrige pharmazeutische zusammensetzung.
US4815446A (en) * 1985-05-09 1989-03-28 Alpha Therapeutic Corporation Process for treating metastasis of cancerous tumors
JPS6256218A (ja) * 1985-09-04 1987-03-11 Kawasaki Steel Corp 掘削集荷装置
ES2054658T3 (es) * 1986-01-24 1994-08-16 Childrens Hosp Medical Center Metodo para la preparacion de una emulsion fisiologicamente aceptable.
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4866096A (en) * 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions

Also Published As

Publication number Publication date
US4781676B1 (enExample) 1990-06-12
US4781676A (en) 1988-11-01
EP0279379A1 (en) 1988-08-24
JPS63222114A (ja) 1988-09-16
ZA881184B (en) 1989-10-25
CA1311420C (en) 1992-12-15
EP0279379B1 (en) 1992-11-04
DE3875629T2 (de) 1993-06-03
KR880009642A (ko) 1988-10-04
MX168608B (es) 1993-06-01
DE3875629D1 (de) 1992-12-10

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