ES2051684T3 - Metodo de preparacion de inhibidor alfa-1-proteinasa. - Google Patents
Metodo de preparacion de inhibidor alfa-1-proteinasa.Info
- Publication number
- ES2051684T3 ES2051684T3 ES86114461T ES86114461T ES2051684T3 ES 2051684 T3 ES2051684 T3 ES 2051684T3 ES 86114461 T ES86114461 T ES 86114461T ES 86114461 T ES86114461 T ES 86114461T ES 2051684 T3 ES2051684 T3 ES 2051684T3
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- proteinase inhibitor
- resin
- preparation
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/902—Materials removed
- Y10S210/903—Nitrogenous
- Y10S210/905—Protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE PRESENTA UN METODO PARA SEPARAR UN INHIBIDOR DE ALFA-1-PROTEINASA (TAMBIEN CONOCIDO COMO ALFA-1-ANTITRIPSINA) DE UNA SOLUCION ACUOSA DE PROTEINAS DE PLASMA, ESPECIALMENTE DE COHN EFFLUENT II X III Y COHN EFFLUENT I. EL METODO INCLUYE LAS ETAPAS DE: TRATAMIENTO DE LA SOLUCION ACUOSA PARA DISMINUIR LA CONCENTRACION DE LAS SALES Y, OPCIONALMENTE, SU CONTENIDO DE ALCOHOL; TRATAMIENTO DE LA SOLUCION RESULTANTE CON UNA RESINA CAMBIADORA DE ANIONES CON AFINIDAD SELECTIVA PARA EL INHIBIDOR DE ALFA-1-PROTEINASA PARA RETENER SELECTIVAMENTE EL INHIBIDOR DE ALFA-1-PROTEINASA Y DEJAR ELUIR LAS PROTEINAS DE PLASMA QUE NO SE QUIEREN, A TRAVES DE LA RESINA; DESPLAZAMIENTO DEL INHIBIDOR DE ALFA-1-PROTEINASA DE LA RESINA Y RECUPERACION DEL MISMO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/793,807 US4697003A (en) | 1985-11-01 | 1985-11-01 | Method of preparing alpha-1-proteinase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2051684T3 true ES2051684T3 (es) | 1994-07-01 |
Family
ID=25160853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86114461T Expired - Lifetime ES2051684T3 (es) | 1985-11-01 | 1986-10-18 | Metodo de preparacion de inhibidor alfa-1-proteinasa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4697003A (es) |
EP (1) | EP0221426B1 (es) |
JP (1) | JPH0764750B2 (es) |
AT (1) | ATE79633T1 (es) |
AU (1) | AU591397B2 (es) |
CA (1) | CA1286848C (es) |
DE (1) | DE3686470T2 (es) |
ES (1) | ES2051684T3 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4629567A (en) * | 1986-03-07 | 1986-12-16 | Smithkline-Rit | Alpha-1-antiprotease purification |
DE3612137A1 (de) * | 1986-04-10 | 1987-10-15 | Biotest Pharma Gmbh | Steriles plasmaaustauschmittel |
US4808314A (en) * | 1987-09-18 | 1989-02-28 | Scripps Clinic And Research Foundation | Method for reducing bacterial endotoxin contamination in solutions of macromolecules |
US5151358A (en) * | 1989-06-13 | 1992-09-29 | Genencor International, Inc. | Processes for the recovery of naturally produced chymosin |
US5139943A (en) * | 1989-06-13 | 1992-08-18 | Genencor International, Inc. | Processes for the recovery of microbially produced chymosin |
US5290474A (en) * | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
US5328841A (en) * | 1990-10-05 | 1994-07-12 | Genencor International, Inc. | Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol |
CA2093422C (en) * | 1990-10-05 | 2001-04-03 | DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS | |
DE4407837C1 (de) * | 1994-03-09 | 1995-08-17 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie |
US5616693A (en) * | 1996-07-01 | 1997-04-01 | Alpha Therapeutic Corporation | Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste |
GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
AT407114B (de) * | 1997-06-10 | 2000-12-27 | Immuno Ag | Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung |
US6093804A (en) * | 1998-09-24 | 2000-07-25 | American National Red Cross | Method for purification of alpha-1 proteinase inhibitor |
US6887678B2 (en) * | 1998-12-02 | 2005-05-03 | Cindy L. Bristow | Method for the quantitative determination of proteinase inhibitors |
US6462180B1 (en) | 1999-11-24 | 2002-10-08 | Bayer Corporation | Method of preparing α-1 proteinase inhibitor |
PT1343809E (pt) | 2000-12-14 | 2015-09-22 | Grifols Therapeutics Inc | Método de preparação de inibidor de proteinase alfa-1 |
US7777006B2 (en) * | 2002-12-31 | 2010-08-17 | Csl Behring L.L.C. | Method for purification of alpha-1-antitrypsin |
EP1664123B2 (en) * | 2003-09-22 | 2011-11-30 | Kamada Ltd. | Large scale preparation of alpha-1 proteinase inhibitor and use thereof |
GB0524432D0 (en) * | 2005-11-30 | 2006-01-11 | Nhs Blood & Transplant | Method |
BRPI0707634A2 (pt) * | 2006-02-09 | 2011-05-10 | Kamada Ltd | alfa-1 antitripsina para tratar episàdios de exacerbaÇço de doenÇas pulmonares |
CA2694854C (en) | 2007-08-17 | 2016-09-27 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
CN102180966B (zh) * | 2011-01-28 | 2013-04-03 | 哈尔滨派斯菲科生物制药股份有限公司 | 一种规模化生产人α1-抗胰蛋白酶的方法 |
CN103889436A (zh) | 2011-12-30 | 2014-06-25 | 基立福有限公司 | 用于延迟肺部症状加重的发作或进展的α1-蛋白酶抑制剂 |
WO2017066683A1 (en) | 2015-10-15 | 2017-04-20 | Plasma Technologies, Llc | Methods for extracting proteins from blood plasma |
CA3012694A1 (en) | 2016-02-03 | 2017-08-10 | Plasma Technologies, Llc | Methods for extracting proteins from a blood-based material |
US10815270B1 (en) | 2019-09-20 | 2020-10-27 | Plasma Technologies, Llc | Compositions and methods for high efficiency protein precipitation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL286954A (es) * | 1962-01-03 | |||
US3869436A (en) * | 1971-06-01 | 1975-03-04 | Statens Bakteriologiska Lab | Method for fractionating plasma proteins using peg and ion-exchangers |
US4100149A (en) * | 1975-08-28 | 1978-07-11 | Rhone-Poulenc Industries | Method of separating proteins by ion exchange |
US4379087A (en) * | 1982-06-17 | 1983-04-05 | Cutter Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor |
US4656254A (en) * | 1985-12-02 | 1987-04-07 | Miles Laboratories, Inc. | Method of preparing alpha-1-proteinase inhibitor and antithrombin III |
US4629567A (en) * | 1986-03-07 | 1986-12-16 | Smithkline-Rit | Alpha-1-antiprotease purification |
-
1985
- 1985-11-01 US US06/793,807 patent/US4697003A/en not_active Expired - Lifetime
-
1986
- 1986-10-18 EP EP86114461A patent/EP0221426B1/en not_active Expired - Lifetime
- 1986-10-18 DE DE8686114461T patent/DE3686470T2/de not_active Expired - Lifetime
- 1986-10-18 ES ES86114461T patent/ES2051684T3/es not_active Expired - Lifetime
- 1986-10-18 AT AT86114461T patent/ATE79633T1/de not_active IP Right Cessation
- 1986-10-30 CA CA000521806A patent/CA1286848C/en not_active Expired - Lifetime
- 1986-10-31 JP JP61258702A patent/JPH0764750B2/ja not_active Expired - Lifetime
- 1986-10-31 AU AU64624/86A patent/AU591397B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3686470D1 (de) | 1992-09-24 |
EP0221426A2 (en) | 1987-05-13 |
CA1286848C (en) | 1991-07-23 |
US4697003A (en) | 1987-09-29 |
ATE79633T1 (de) | 1992-09-15 |
AU6462486A (en) | 1987-05-07 |
JPH0764750B2 (ja) | 1995-07-12 |
EP0221426A3 (en) | 1989-02-08 |
AU591397B2 (en) | 1989-11-30 |
DE3686470T2 (de) | 1993-01-21 |
JPS62108821A (ja) | 1987-05-20 |
EP0221426B1 (en) | 1992-08-19 |
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