ES2049314T5 - Un dispositivo de analisis para diagnostico. - Google Patents
Un dispositivo de analisis para diagnostico.Info
- Publication number
- ES2049314T5 ES2049314T5 ES89201638T ES89201638T ES2049314T5 ES 2049314 T5 ES2049314 T5 ES 2049314T5 ES 89201638 T ES89201638 T ES 89201638T ES 89201638 T ES89201638 T ES 89201638T ES 2049314 T5 ES2049314 T5 ES 2049314T5
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- diagnosis
- analysis device
- projections
- parallel spaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
Abstract
SE DESCRIBE UN DISPOSITIVO PARA PROPORCIONAR UN FLUJO DE LIQUIDO CONTROLADO EN UNA ZONA DE FLUJO LIQUIDO ENTRE DOS SUPERFICIES, DONDE UNA SUPERFICIE TIENE VARIOS RESALTES O AREAS EN RELIEVE, DISPUESTAS SUSTANCIALMENTE EN TODA LA SUPERFICIE EN LA ZONA DE FLUJO DE LIQUIDO, Y UNA ABERTURA PARA PERMITIR LA ENTRADA DE LIQUIDO ENTRE LAS DOS SUPERFICIES. EN UNA INCORPORACION PREFERIDA, LOS RESALTES EN LA PRIMERA SUPERFICIE ESTAN DISPUESTOS EN LINEAS DISPUESTAS PARALELAMENTE Y EN COLUMNAS ESPACIADAS PARALELAMENTE. LA SEGUNDA SUPERFICIE PUEDE ESTAR SOBRE LA SUPERFICIE DE UNA CAPA DE UN ELEMENTO DE ENSAYO DE DIAGNOSTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/210,732 US5051237A (en) | 1988-06-23 | 1988-06-23 | Liquid transport system |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2049314T3 ES2049314T3 (es) | 1994-04-16 |
ES2049314T5 true ES2049314T5 (es) | 1998-03-16 |
Family
ID=22784060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89201638T Expired - Lifetime ES2049314T5 (es) | 1988-06-23 | 1989-06-22 | Un dispositivo de analisis para diagnostico. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5051237A (es) |
EP (1) | EP0348006B2 (es) |
JP (1) | JPH01321359A (es) |
AT (1) | ATE98523T1 (es) |
CA (1) | CA1310887C (es) |
DE (1) | DE68911395T3 (es) |
ES (1) | ES2049314T5 (es) |
Families Citing this family (89)
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---|---|---|---|---|
US5250443A (en) * | 1988-11-23 | 1993-10-05 | Pb Diagnostic Systems, Inc. | Biological diagnostic assay system |
AU637480B2 (en) * | 1990-03-12 | 1993-05-27 | Biosite Diagnostics Incorporated | Bioassay device with non-absorbent textured capillary surface |
DE4022655A1 (de) * | 1990-07-17 | 1992-01-23 | Boehringer Mannheim Gmbh | Testkit zur bestimmung eines analyten in einer pastoesen probe, insbesondere in stuhl |
AU646305B2 (en) * | 1990-10-30 | 1994-02-17 | Hypoguard (Uk) Limited | Collection and display device |
JPH04188065A (ja) * | 1990-11-21 | 1992-07-06 | Kyoto Daiichi Kagaku:Kk | 液体試料分析用具および分析方法 |
US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
US5607863A (en) | 1991-05-29 | 1997-03-04 | Smithkline Diagnostics, Inc. | Barrier-controlled assay device |
US5869345A (en) | 1991-05-29 | 1999-02-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing conductive barrier |
US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
US5468648A (en) | 1991-05-29 | 1995-11-21 | Smithkline Diagnostics, Inc. | Interrupted-flow assay device |
US6007999A (en) * | 1991-07-31 | 1999-12-28 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
US5726010A (en) * | 1991-07-31 | 1998-03-10 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
US5885527A (en) * | 1992-05-21 | 1999-03-23 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membrances |
US5458852A (en) * | 1992-05-21 | 1995-10-17 | Biosite Diagnostics, Inc. | Diagnostic devices for the controlled movement of reagents without membranes |
US6156270A (en) * | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US7524456B1 (en) | 1992-05-21 | 2009-04-28 | Biosite Incorporated | Diagnostic devices for the controlled movement of reagents without membranes |
US6767510B1 (en) | 1992-05-21 | 2004-07-27 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US6905882B2 (en) * | 1992-05-21 | 2005-06-14 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
GB9218118D0 (en) * | 1992-08-26 | 1992-10-14 | Hypoguard Uk Ltd | Device |
US5820826A (en) * | 1992-09-03 | 1998-10-13 | Boehringer Mannheim Company | Casing means for analytical test apparatus |
US5399486A (en) * | 1993-02-18 | 1995-03-21 | Biocircuits Corporation | Disposable unit in diagnostic assays |
US5660798A (en) * | 1993-04-20 | 1997-08-26 | Actimed Laboratories, Inc. | Apparatus for red blood cell separation |
US5766552A (en) * | 1993-04-20 | 1998-06-16 | Actimed Laboratories, Inc. | Apparatus for red blood cell separation |
DE4323672A1 (de) * | 1993-07-15 | 1995-01-19 | Boehringer Mannheim Gmbh | Vorrichtung zur gleichzeitigen Bestimmung von Analyten |
US5447689A (en) * | 1994-03-01 | 1995-09-05 | Actimed Laboratories, Inc. | Method and apparatus for flow control |
US5559596A (en) * | 1995-02-13 | 1996-09-24 | Point Source, Inc. | Fluid sample analysis by optical fourier transform imaging |
US5760894A (en) * | 1995-02-13 | 1998-06-02 | Point Source, Inc. | Liquid sample analysis in an optical fourier transform system |
DE19629654A1 (de) * | 1996-07-23 | 1998-05-07 | Boehringer Mannheim Gmbh | Diagnostischer Testträger mit Kapillarspalt |
DE19629657A1 (de) * | 1996-07-23 | 1998-01-29 | Boehringer Mannheim Gmbh | Volumenunabhängiger diagnostischer Testträger und Verfahren zur Bestimmung von Analyt mit dessen Hilfe |
US6113855A (en) * | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
US5879951A (en) | 1997-01-29 | 1999-03-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing unidirectional flow |
US5939252A (en) | 1997-05-09 | 1999-08-17 | Lennon; Donald J. | Detachable-element assay device |
US6096268A (en) * | 1997-10-31 | 2000-08-01 | Dade Behring Inc. | Chromogenic and turbidimetric assay device |
DE19753851A1 (de) | 1997-12-04 | 1999-06-10 | Roche Diagnostics Gmbh | Vorrichtung zum kapillaren Flüssigkeitstransport |
DE19859693A1 (de) | 1998-12-23 | 2000-06-29 | Microparts Gmbh | Vorrichtung zum Ableiten einer Flüssigkeit aus Kapillaren |
US6780606B1 (en) | 1999-02-26 | 2004-08-24 | Synx Pharma, Inc. | Method for diagnosing and distinguishing stroke and diagnostic devices for use therein |
US6319719B1 (en) * | 1999-10-28 | 2001-11-20 | Roche Diagnostics Corporation | Capillary hematocrit separation structure and method |
US6413395B1 (en) * | 1999-12-16 | 2002-07-02 | Roche Diagnostics Corporation | Biosensor apparatus |
US6406672B1 (en) * | 2000-01-28 | 2002-06-18 | Roche Diagnostics | Plasma retention structure providing internal flow |
US6451264B1 (en) | 2000-01-28 | 2002-09-17 | Roche Diagnostics Corporation | Fluid flow control in curved capillary channels |
US7485454B1 (en) | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
US6783992B2 (en) * | 2001-01-03 | 2004-08-31 | Agilent Technologies, Inc. | Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples |
US7879293B2 (en) * | 2001-09-28 | 2011-02-01 | Orasure Technologies, Inc. | Sample collector and test device |
US6755949B1 (en) * | 2001-10-09 | 2004-06-29 | Roche Diagnostics Corporation | Biosensor |
DE10224518A1 (de) * | 2002-05-31 | 2003-12-11 | Gruenenthal Gmbh | Zweikanal-Durchflussmesszelle |
WO2003106032A1 (de) * | 2002-06-14 | 2003-12-24 | Axaron Bioscience Ag | Hybridisierungskammer |
ATE465410T1 (de) | 2002-08-13 | 2010-05-15 | N Dia Inc | Vorrichtungen und verfahren zum nachweis von fruchtwasser in vaginalsekreten |
US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
CN100373820C (zh) * | 2003-10-08 | 2008-03-05 | 松下电器产业株式会社 | 道路-车辆通信系统以及用于其中的路边设备和移动设备 |
DE10354806A1 (de) * | 2003-11-21 | 2005-06-02 | Boehringer Ingelheim Microparts Gmbh | Probenträger |
DE10360220A1 (de) * | 2003-12-20 | 2005-07-21 | Steag Microparts Gmbh | Mikrostrukturierte Anordnung zur blasenfreien Befüllung zumindest eines Systems zur Ableitung von Flüssigkeiten, Vorrichtung mit einer solchen Anordnung und Befüllungsverfahren |
ES2439225T3 (es) | 2004-01-26 | 2014-01-22 | President And Fellows Of Harvard College | Sistema y método para el suministro de fluidos |
US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
SE0400662D0 (sv) | 2004-03-24 | 2004-03-24 | Aamic Ab | Assay device and method |
SE527036C2 (sv) * | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
DE102004027422A1 (de) | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
SE0501418L (sv) | 2005-06-20 | 2006-09-26 | Aamic Ab | Metod och medel för att åstadkomma vätsketransport |
DE102006025477B4 (de) * | 2006-05-30 | 2009-01-15 | Ekf - Diagnostic Gmbh | Küvette und Verfahren zu ihrer Herstellung |
SE531948C2 (sv) * | 2006-06-20 | 2009-09-15 | Aamic Ab | Analysanordning för vätskeprover innefattande filter i direkt kontakt med projektioner |
US7592181B2 (en) * | 2006-09-25 | 2009-09-22 | Diagnostica, Inc. | Occult blood testing device |
US7749775B2 (en) * | 2006-10-03 | 2010-07-06 | Jonathan Scott Maher | Immunoassay test device and method of use |
ES2687620T3 (es) | 2007-05-04 | 2018-10-26 | Opko Diagnostics, Llc | Dispositivo y método para análisis en sistemas microfluídicos |
EP2285491A1 (en) | 2008-04-25 | 2011-02-23 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
KR101311020B1 (ko) * | 2008-11-07 | 2013-09-25 | 에프. 호프만-라 로슈 아게 | 광도계 반응 필름용 세립 충전물질 |
EP2376226B1 (en) | 2008-12-18 | 2018-09-12 | Opko Diagnostics, LLC | Improved reagent storage in microfluidic systems and related articles and methods |
TR201815133T4 (tr) | 2009-02-02 | 2018-11-21 | Opko Diagnostics Llc | Mikrofilidik cihazlar ile ışık etkileşiminin kontrol edilmesi için yapılar. |
EP2269737B1 (en) | 2009-07-02 | 2017-09-13 | Amic AB | Assay device comprising serial reaction zones |
MX2012005951A (es) | 2009-11-24 | 2012-10-01 | Opko Diagnostics Llc | Mezclado y entrega de fluidos en sistemas microfluídicos. |
WO2011130629A1 (en) | 2010-04-16 | 2011-10-20 | Claros Diagnostics, Inc. | Systems and devices for analysis of samples |
USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
BR112014021776B1 (pt) | 2012-03-05 | 2022-08-09 | Opko Diagnostics, Llc | Sistema de ensaio e método para a determinação de uma probabilidade de um evento associado com o câncer da próstata |
US9044781B2 (en) * | 2012-12-04 | 2015-06-02 | Fei Company | Microfluidics delivery systems |
CN107727841B (zh) | 2013-01-02 | 2021-05-25 | 凯杰科学有限责任公司 | 预测孕妇分娩时间的方法 |
ES2741001T3 (es) | 2013-03-13 | 2020-02-07 | Opko Diagnostics Llc | Mezcla de fluidos en sistemas fluídicos |
WO2014172390A2 (en) | 2013-04-15 | 2014-10-23 | Cedars-Sinai Medical Center | Methods for detecting cancer metastasis |
US9545629B2 (en) * | 2013-10-24 | 2017-01-17 | Canon Kabushiki Kaisha | Micro flow-channel chip, method for manufacturing the same, and device for analysis |
FR3012982B1 (fr) * | 2013-11-08 | 2015-12-25 | Espci Innov | Procede de stockage et de concentration d'un compose volatil |
AU2015249666A1 (en) | 2014-04-25 | 2016-11-17 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating subjects with immune-mediated diseases |
CN104502621A (zh) * | 2014-11-25 | 2015-04-08 | 湖南欧杰生物科技发展有限公司 | 一种计数池 |
KR102587637B1 (ko) | 2014-12-12 | 2023-10-10 | 옵코 다이어그노스틱스, 엘엘씨 | 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템 |
USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
CA3005084A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
CN109153020A (zh) * | 2016-04-28 | 2019-01-04 | 沙特基础工业全球技术公司 | 微流体器件 |
US10656164B2 (en) | 2016-12-22 | 2020-05-19 | Qiagen Sciences, Llc | Screening asymptomatic pregnant woman for preterm birth |
US10935555B2 (en) | 2016-12-22 | 2021-03-02 | Qiagen Sciences, Llc | Determining candidate for induction of labor |
JP7004333B2 (ja) | 2017-02-06 | 2022-01-21 | イーエフエー―エンジニアリング フォー オール エルティーディー. | 携帯用のデジタル診断デバイス |
CN108722504A (zh) * | 2017-04-19 | 2018-11-02 | 光宝电子(广州)有限公司 | 检测装置及其注入口结构 |
TWI661184B (zh) * | 2017-04-19 | 2019-06-01 | 天亮醫療器材股份有限公司 | 檢測裝置及其注入口結構 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US4002056A (en) * | 1975-03-14 | 1977-01-11 | Ovutime, Inc. | Processes and devices for determining properties of viscous fluids |
US4233029A (en) * | 1978-10-25 | 1980-11-11 | Eastman Kodak Company | Liquid transport device and method |
CA1129498A (en) * | 1978-10-25 | 1982-08-10 | Richard L. Columbus | Structural configuration and method for transport of a liquid drop through an ingress aperture |
US4254083A (en) * | 1979-07-23 | 1981-03-03 | Eastman Kodak Company | Structural configuration for transport of a liquid drop through an ingress aperture |
US4271119A (en) * | 1979-07-23 | 1981-06-02 | Eastman Kodak Company | Capillary transport device having connected transport zones |
US4302313A (en) * | 1979-07-23 | 1981-11-24 | Eastman Kodak Company | Electrode-containing device with capillary transport between electrodes |
US4310399A (en) * | 1979-07-23 | 1982-01-12 | Eastman Kodak Company | Liquid transport device containing means for delaying capillary flow |
US4323536A (en) * | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
US4413407A (en) * | 1980-03-10 | 1983-11-08 | Eastman Kodak Company | Method for forming an electrode-containing device with capillary transport between electrodes |
US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US4439526A (en) * | 1982-07-26 | 1984-03-27 | Eastman Kodak Company | Clustered ingress apertures for capillary transport devices and method of use |
US4549952A (en) * | 1982-11-22 | 1985-10-29 | Eastman Kodak Company | Capillary transport device having means for increasing the viscosity of the transported liquid |
US4741832A (en) * | 1984-05-15 | 1988-05-03 | The Trustees Of Columbia, University In The City Of New York | Purification apparatus and method employing a regenerable ligand |
WO1987006003A1 (en) * | 1986-03-25 | 1987-10-08 | P B Diagnostic Systems, Inc. | Biological diagnostic device |
-
1988
- 1988-06-23 US US07/210,732 patent/US5051237A/en not_active Expired - Lifetime
-
1989
- 1989-04-05 CA CA000595774A patent/CA1310887C/en not_active Expired - Fee Related
- 1989-04-27 JP JP1106132A patent/JPH01321359A/ja active Pending
- 1989-06-22 AT AT89201638T patent/ATE98523T1/de not_active IP Right Cessation
- 1989-06-22 DE DE68911395T patent/DE68911395T3/de not_active Expired - Fee Related
- 1989-06-22 EP EP89201638A patent/EP0348006B2/en not_active Expired - Lifetime
- 1989-06-22 ES ES89201638T patent/ES2049314T5/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH01321359A (ja) | 1989-12-27 |
US5051237A (en) | 1991-09-24 |
EP0348006A3 (en) | 1990-11-28 |
ES2049314T3 (es) | 1994-04-16 |
ATE98523T1 (de) | 1994-01-15 |
DE68911395T2 (de) | 1994-04-14 |
EP0348006A2 (en) | 1989-12-27 |
EP0348006B2 (en) | 1997-10-22 |
CA1310887C (en) | 1992-12-01 |
AU610997B2 (en) | 1991-05-30 |
AU3103589A (en) | 1990-01-04 |
EP0348006B1 (en) | 1993-12-15 |
DE68911395D1 (de) | 1994-01-27 |
DE68911395T3 (de) | 1998-01-29 |
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