ES2047544T3 - Produccion en alta concentracion de somatomedina c humana. - Google Patents
Produccion en alta concentracion de somatomedina c humana.Info
- Publication number
- ES2047544T3 ES2047544T3 ES88302994T ES88302994T ES2047544T3 ES 2047544 T3 ES2047544 T3 ES 2047544T3 ES 88302994 T ES88302994 T ES 88302994T ES 88302994 T ES88302994 T ES 88302994T ES 2047544 T3 ES2047544 T3 ES 2047544T3
- Authority
- ES
- Spain
- Prior art keywords
- somatomedine
- human
- high concentration
- concentration production
- titer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO DE FERMENTACION DE ALTA CONCENTRACION EMPLEANDO CELULAS TRASNFORMADORAS DE ESCHERICHIA COLI PORTADORAS DE UN PLASMIDO QUE CONTIENE ADN CODIFICADOR DE SOMATOMEDINA C. EMPLEANDO EL METODO DE ESTA INVENCION SE HAN OBTENIDO CONCENTRACIONES DE 900-1000 MG/L QUE REPRESENTAN ALREDEDOR DEL DOBLE DE LOS OBTENIDO POR PROCEDIMIENTOS DE TIPO MAS ANTIGUO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/034,847 US5104796A (en) | 1987-04-06 | 1987-04-06 | High titer production of human somatomedin c |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2047544T3 true ES2047544T3 (es) | 1994-03-01 |
Family
ID=21878973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88302994T Expired - Lifetime ES2047544T3 (es) | 1987-04-06 | 1988-04-05 | Produccion en alta concentracion de somatomedina c humana. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5104796A (es) |
EP (1) | EP0286345B1 (es) |
JP (1) | JP2609462B2 (es) |
KR (1) | KR960011523B1 (es) |
AT (1) | ATE98654T1 (es) |
AU (1) | AU607986B2 (es) |
DE (1) | DE3886250T2 (es) |
ES (1) | ES2047544T3 (es) |
NZ (1) | NZ224113A (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5200509A (en) * | 1987-04-06 | 1993-04-06 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5589364A (en) * | 1994-07-29 | 1996-12-31 | Magainin Pharmaceuticals Inc. | Recombinant production of biologically active peptides and proteins |
WO1996007744A1 (en) * | 1994-09-08 | 1996-03-14 | Chiron Corporation | A method of improved production of insulin-like growth factor |
US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3926737A (en) * | 1972-05-10 | 1975-12-16 | New Brunswick Scientific Co | Method and apparatus for control of biochemical processes |
US4413305A (en) * | 1982-06-21 | 1983-11-01 | The Bendix Corporation | Terminal for a capacitor and a method of forming same |
BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio- Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
US4788144A (en) * | 1985-06-28 | 1988-11-29 | International Minerals & Chemical Corp. | Fermentation process for the high level production of swine growth |
US4762784A (en) * | 1985-07-15 | 1988-08-09 | International Minerals & Chemical Corp. | Fermemtation process for the high level production of bovine growth hormone |
US4769361A (en) * | 1986-08-07 | 1988-09-06 | International Minerals & Chemical Corp. | Method for purifying and isolating two ionic forms of somatomedin C |
-
1987
- 1987-04-06 US US07/034,847 patent/US5104796A/en not_active Expired - Fee Related
-
1988
- 1988-03-31 NZ NZ224113A patent/NZ224113A/en unknown
- 1988-04-05 JP JP63082404A patent/JP2609462B2/ja not_active Expired - Lifetime
- 1988-04-05 DE DE88302994T patent/DE3886250T2/de not_active Expired - Fee Related
- 1988-04-05 ES ES88302994T patent/ES2047544T3/es not_active Expired - Lifetime
- 1988-04-05 AT AT88302994T patent/ATE98654T1/de not_active IP Right Cessation
- 1988-04-05 AU AU14393/88A patent/AU607986B2/en not_active Ceased
- 1988-04-05 EP EP88302994A patent/EP0286345B1/en not_active Expired - Lifetime
- 1988-04-06 KR KR1019880003812A patent/KR960011523B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1439388A (en) | 1988-10-06 |
KR960011523B1 (ko) | 1996-08-23 |
ATE98654T1 (de) | 1994-01-15 |
DE3886250T2 (de) | 1994-05-05 |
JP2609462B2 (ja) | 1997-05-14 |
EP0286345A3 (en) | 1989-10-04 |
AU607986B2 (en) | 1991-03-21 |
JPS6420098A (en) | 1989-01-24 |
NZ224113A (en) | 1990-11-27 |
KR880012757A (ko) | 1988-11-29 |
DE3886250D1 (de) | 1994-01-27 |
EP0286345A2 (en) | 1988-10-12 |
EP0286345B1 (en) | 1993-12-15 |
US5104796A (en) | 1992-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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