ES2044829T1 - Una composicion para el tratamiento in vivo de da\os en los tejidos producidos por isquemia u otra disfuncion proveniente de oxidacion. - Google Patents
Una composicion para el tratamiento in vivo de da\os en los tejidos producidos por isquemia u otra disfuncion proveniente de oxidacion.Info
- Publication number
- ES2044829T1 ES2044829T1 ES90915877T ES90915877T ES2044829T1 ES 2044829 T1 ES2044829 T1 ES 2044829T1 ES 90915877 T ES90915877 T ES 90915877T ES 90915877 T ES90915877 T ES 90915877T ES 2044829 T1 ES2044829 T1 ES 2044829T1
- Authority
- ES
- Spain
- Prior art keywords
- spin
- trapping
- administration
- treatment
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE DESCRIBEN COMPOSICIONES CONTENIENDO COMO INGREDIENTE ACTIVO UN REACTIVO QUE ES ATRAPADO EN EL CENTRIFUGADO, PREFERENTEMENTE (ALFA)-FENIL BUTIL NITRONA (PNB), O SUS DERIVADOS QUE SON ATRAPADOS EN EL CENTRIFUGADO, EN UN PORTADOR FARMACEUTICO APROPIADO PARA LA ADMINISTRACION A UN PACIENTE, PARA EL TRATAMIENTO O PREVENCION DE SINTOMAS ASOCIADOS CON ATAQUES U OTROS DAÑOS ISQUEMICOS, ENVEJECIMIENTO U OTRAS CONDICIONES ASOCIADAS CON EL DAÑO OXIDATIVO A LOS TEJIDOS. PARA LA PREVENCION O TRATAMIENTO DEL DAÑO COMO RESULTADO DE LA ISQUEMIA, LAS COMPOSICIONES SE ADMINISTRAN ANTES O DURANTE LA ISQUEMIA EN UNA DOSIS EFICAZ, PARA PREVENIR O INVERTIR LA PREDISPOSICION DE LAS CELULAS AL DAÑO RESULTANTE DEL EMPOBRECIMIENTO DE ATP Y EL DAÑO DE LA GENERACION DE RADICAL LIBRE QUE SIGUE A LA REPERCUSION. EJEMPLOS DE ENFERMEDADES QUE PUEDEN SER TRATADAS INCLUYEN; ATAQUES, MENINGITIS, PERDIDA NEURONAL PROGRESIVA DEBIDO A LA ENFERMEDAD DE PARKINSON, DEMENCIA SENIL, DROGADICCION, ENFERMEDADES QUE APARECEN POR LAEXPOSICION A OXIGENO A GRAN PRESION O ENTORNOS CON OXIGENO ENRIQUECIDO, Y UNA HEMORRAGIA DEL TEJIDO NERVIOSO COMO RESULTADO DE UN TRAUMATISMO. PARA EL TRATAMIENTO DEL ENVEJECIMIENTO, LAS COMPOSICIONES SE ADMINISTRAN PREFERENTEMENTE UNA O DOS VECES AL DIA MEDIANTE ADMINISTRACION ORAL DURANTE UN PERIODO DE DOS SEMANAS. SE OBSERVA UNA SIGNIFICANTE REDUCCION DE PROTEINAS OXIDADAS Y RECUPERACION DE MEMORIA AL CABO DE SIETE DIAS DESPUES DEL COMIENZO DEL TRATAMIENTO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/422,651 US5025032A (en) | 1989-10-17 | 1989-10-17 | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
US58917790A | 1990-09-27 | 1990-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2044829T1 true ES2044829T1 (es) | 1994-01-16 |
ES2044829T3 ES2044829T3 (es) | 1995-01-16 |
Family
ID=27025701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90915877T Expired - Lifetime ES2044829T3 (es) | 1989-10-17 | 1990-10-17 | Metodo y composiciones para la inhibicion de alteraciones asociadas con las lesiones oxidativas de los tejidos. |
Country Status (12)
Country | Link |
---|---|
US (4) | US5405874A (es) |
EP (1) | EP0496796B1 (es) |
JP (5) | JP2620413B2 (es) |
KR (1) | KR960008230B1 (es) |
AT (1) | ATE110565T1 (es) |
AU (4) | AU653921B2 (es) |
CA (1) | CA2069961C (es) |
DE (1) | DE69012138T2 (es) |
DK (1) | DK0496796T3 (es) |
ES (1) | ES2044829T3 (es) |
HK (1) | HK1007281A1 (es) |
WO (1) | WO1991005552A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2395803A1 (es) * | 2011-08-01 | 2013-02-15 | Consejo Superior De Investigaciones Científicas (Csic) - 80% | Quinolilnitronas |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69012138T2 (de) * | 1989-10-17 | 1995-04-06 | Oklahoma Medical Research Foundation, Oklahoma, Okla. | Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten. |
US5681845A (en) * | 1989-10-17 | 1997-10-28 | Oklahoma Medical Research Foundation | DMPO spin trapping compositions and methods of use thereof |
US20050107366A1 (en) * | 1991-06-18 | 2005-05-19 | Carney John M. | Spin trapping pharmaceutical compositions and methods for use thereof |
ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
US6002001A (en) | 1991-06-18 | 1999-12-14 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
US5292746A (en) * | 1991-09-12 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock |
NZ244268A (en) * | 1991-09-12 | 1994-09-27 | Merrell Pharma Inc | N-oxide quinoline derivatives and pharmaceutical compositions |
JPH0656669A (ja) * | 1992-06-11 | 1994-03-01 | Asahi Breweries Ltd | 活性酸素消去作用を持つプテリン誘導体製剤 |
JPH08505406A (ja) * | 1993-10-25 | 1996-06-11 | オゥクラホゥマ、メディカル、リサーチ、ファウンデイシャン | 新規のリン含有スピン捕捉組成物 |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
FR2731428B1 (fr) * | 1995-03-06 | 1997-06-06 | Centre Nat Rech Scient | Derives phosphoryles de nitrones, leur procede de preparation et compositions les contenant |
KR100512675B1 (ko) * | 1995-09-11 | 2006-08-10 | 아벤티스 파마슈티칼스 인크. | 사이클릭니트론및이를포함하는약제학적조성물 |
CA2235765C (en) * | 1995-11-17 | 2006-04-04 | David A. Becker | Azulenyl nitrone spin trapping agents, methods of making and using same |
AU725432B2 (en) * | 1996-04-17 | 2000-10-12 | Centaur Pharmaceuticals, Inc. | Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection |
EP0910370B1 (en) * | 1996-04-23 | 2004-04-07 | Centaur Pharmaceuticals, Inc. | Compositions comprising a nitrone compound for use in treating uveitis |
US5900227A (en) * | 1996-06-17 | 1999-05-04 | Oklahoma Medical Research Foundation | Multicyclic nitrone spin trapping compositions |
EP1021430A1 (en) * | 1996-07-19 | 2000-07-26 | Centaur Pharmaceuticals, Inc. | Furan nitrone compounds |
TW429241B (en) * | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
US6046232A (en) * | 1997-10-17 | 2000-04-04 | Centaur Pharmaceuticals, Inc. | α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same |
US5998469A (en) * | 1998-01-16 | 1999-12-07 | Centaur Pharmaceuticals, Inc. | Thioether furan nitrone compounds |
DE69904018D1 (en) * | 1998-01-16 | 2003-01-02 | Centaur Pharmaceuticals Inc | Thiophennitronderivate |
DE69917643T2 (de) | 1998-07-17 | 2004-10-07 | Renovis Inc | Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen |
US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
UA66401C2 (en) | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
WO2000074672A1 (en) * | 1999-06-09 | 2000-12-14 | Department Of The Army, U.S. Government | Method and compositions for treating and preventing retinal damage |
CA2404291A1 (en) * | 2000-03-30 | 2001-10-11 | Oklahoma Medical Research Foundation | Butylnitrone containing compositons for inhibition of cancer development |
SE0001916D0 (sv) * | 2000-05-23 | 2000-05-23 | Astrazeneca Ab | Novel formulation |
WO2002065993A2 (en) | 2001-01-08 | 2002-08-29 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
US20030045461A1 (en) * | 2001-09-06 | 2003-03-06 | Jen-Chang Hsia | Composition and methods of esterified nitroxides gated with carboxylic acids |
FR2846968B1 (fr) | 2002-11-08 | 2005-02-04 | Salles Jean Pierre | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone |
US6762322B1 (en) * | 2002-12-20 | 2004-07-13 | Goodyear Tire & Rubber Company | Preparation of nitrone derivatives |
US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
US7125934B1 (en) * | 2005-06-28 | 2006-10-24 | The Goodyear Tire & Rubber Company | Functionalization of living rubbery polymers with nitrones |
EP2054047B1 (en) * | 2006-07-25 | 2014-12-17 | Hough Ear Institute | Methods for treating acute acoustic trauma |
WO2009102808A2 (en) | 2008-02-12 | 2009-08-20 | Tosk, Incorporated | Doxorubicin adjuvants to reduce toxicity and methods for using the same |
WO2009110585A1 (ja) * | 2008-03-07 | 2009-09-11 | 国立大学法人熊本大学 | 電子スピン共鳴測定用試料溶液及びその乾固物,並びにそれらを用いた測定方法 |
US8591146B2 (en) * | 2009-04-20 | 2013-11-26 | Volvo Construction Equipment Ab | Integrated paving system and method |
US9034926B2 (en) | 2010-12-30 | 2015-05-19 | Nicholas V. Perricone | Topical nitrone spin trap compositions for psoriasis |
US8986739B2 (en) | 2011-02-28 | 2015-03-24 | Nicholas V. Perricone | Treatment of urinary incontinence using nitrone spin traps |
DE102011088787A1 (de) | 2011-12-16 | 2013-06-20 | Evonik Industries Ag | Siloxannitrone und deren Anwendung |
WO2022169642A1 (en) * | 2021-02-08 | 2022-08-11 | Oklahoma Medical Research Foundation | Okn-007 as a therapeutic agent for neurodegenerative diseases |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE273702C (es) * | ||||
US35112A (en) * | 1862-04-29 | Improvement in head-rests for car-seats | ||
US35213A (en) * | 1862-05-13 | Improved hydrant | ||
US3396027A (en) * | 1964-05-13 | 1968-08-06 | Eastman Kodak Co | Method of noodling gelatin dispersions |
US3365296A (en) | 1964-05-18 | 1968-01-23 | Gen Aniline & Film Corp | Light-sensitive ultraviolet absorbing compounds and diazotype materials containing the same |
US3296145A (en) * | 1965-10-21 | 1967-01-03 | Millmaster Onyx Corp | Quaternary ammonium-tertiary amine oxide compositions |
US3775122A (en) | 1967-07-28 | 1973-11-27 | American Can Co | Image production using photosensitive compositions of nitrone which is heat developed |
US3834073A (en) * | 1971-05-03 | 1974-09-10 | Scm Corp | Phenyl nitrone derivatives useful as seed protectants |
US3849934A (en) * | 1971-05-03 | 1974-11-26 | Scm Corp | Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents |
US3767818A (en) | 1971-05-03 | 1973-10-23 | Scm Corp | Phenyl nitrone containing compositions useful as anti microbial agents |
GB1531278A (en) * | 1975-12-15 | 1978-11-08 | Shionogi & Co | 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof |
GB1588417A (en) * | 1977-03-15 | 1981-04-23 | Agfa Gevaert | Photoresist materials |
US4224340A (en) * | 1977-10-06 | 1980-09-23 | William H. Rorer, Inc. | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds |
US4197314A (en) * | 1977-10-06 | 1980-04-08 | William H. Rorer, Inc. | Method of treating inflammation |
US4214003A (en) * | 1977-10-06 | 1980-07-22 | William H. Rorer, Inc. | Method of treatment |
US4153722A (en) * | 1977-10-06 | 1979-05-08 | William H. Rorer, Inc. | Method of treatment |
US4870002A (en) * | 1981-04-07 | 1989-09-26 | The United States Of America As Represented By The Secretary Of The Air Force | Method of prevention of oxidative injury to cells |
AU1107888A (en) * | 1986-12-29 | 1988-07-27 | Pharmacia Ab | Nitroxide compounds for the preparation of a pharmaceutical composition intended for the prophylaxis and treatment of ischemic cell damage |
AU1362488A (en) * | 1987-01-28 | 1988-08-24 | Peter H. Proctor | Topical composition and method for stimulating hair growth with stable free radicals |
US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
DE69012138T2 (de) * | 1989-10-17 | 1995-04-06 | Oklahoma Medical Research Foundation, Oklahoma, Okla. | Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten. |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
-
1990
- 1990-10-17 DE DE69012138T patent/DE69012138T2/de not_active Expired - Fee Related
- 1990-10-17 EP EP90915877A patent/EP0496796B1/en not_active Expired - Lifetime
- 1990-10-17 WO PCT/US1990/005952 patent/WO1991005552A1/en active IP Right Grant
- 1990-10-17 KR KR1019920700900A patent/KR960008230B1/ko not_active IP Right Cessation
- 1990-10-17 CA CA002069961A patent/CA2069961C/en not_active Expired - Fee Related
- 1990-10-17 JP JP2515036A patent/JP2620413B2/ja not_active Expired - Fee Related
- 1990-10-17 AU AU66133/90A patent/AU653921B2/en not_active Ceased
- 1990-10-17 AT AT90915877T patent/ATE110565T1/de not_active IP Right Cessation
- 1990-10-17 DK DK90915877.6T patent/DK0496796T3/da active
- 1990-10-17 ES ES90915877T patent/ES2044829T3/es not_active Expired - Lifetime
-
1993
- 1993-03-05 US US08/027,559 patent/US5405874A/en not_active Expired - Lifetime
-
1994
- 1994-12-28 US US08/365,548 patent/US5578617A/en not_active Expired - Fee Related
-
1995
- 1995-01-20 AU AU11315/95A patent/AU692197B2/en not_active Ceased
- 1995-06-06 US US08/468,561 patent/US5681965A/en not_active Expired - Fee Related
- 1995-06-06 US US08/468,563 patent/US6107315A/en not_active Expired - Fee Related
-
1996
- 1996-07-09 JP JP8179709A patent/JP2816326B2/ja not_active Expired - Fee Related
-
1998
- 1998-03-25 JP JP10077985A patent/JPH10259128A/ja active Pending
- 1998-03-25 JP JP10077984A patent/JP2975587B2/ja not_active Expired - Fee Related
- 1998-06-24 HK HK98106466A patent/HK1007281A1/xx not_active IP Right Cessation
- 1998-09-04 AU AU83102/98A patent/AU710342B2/en not_active Ceased
- 1998-09-04 AU AU83101/98A patent/AU710341B2/en not_active Ceased
-
2001
- 2001-11-08 JP JP2001343709A patent/JP2002179563A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2395803A1 (es) * | 2011-08-01 | 2013-02-15 | Consejo Superior De Investigaciones Científicas (Csic) - 80% | Quinolilnitronas |
Also Published As
Publication number | Publication date |
---|---|
EP0496796B1 (en) | 1994-08-31 |
AU8310198A (en) | 1998-12-24 |
KR920702220A (ko) | 1992-09-03 |
CA2069961C (en) | 2000-05-02 |
KR960008230B1 (ko) | 1996-06-21 |
AU6613390A (en) | 1991-05-16 |
CA2069961A1 (en) | 1991-04-18 |
DK0496796T3 (da) | 1994-10-03 |
ES2044829T3 (es) | 1995-01-16 |
AU710341B2 (en) | 1999-09-16 |
JP2002179563A (ja) | 2002-06-26 |
AU1131595A (en) | 1995-03-23 |
JPH10259128A (ja) | 1998-09-29 |
AU653921B2 (en) | 1994-10-20 |
US6107315A (en) | 2000-08-22 |
AU710342B2 (en) | 1999-09-16 |
EP0496796A1 (en) | 1992-08-05 |
JP2620413B2 (ja) | 1997-06-11 |
DE69012138D1 (de) | 1994-10-06 |
HK1007281A1 (en) | 1999-04-09 |
US5681965A (en) | 1997-10-28 |
ATE110565T1 (de) | 1994-09-15 |
JPH05505792A (ja) | 1993-08-26 |
JPH10259178A (ja) | 1998-09-29 |
US5578617A (en) | 1996-11-26 |
AU8310298A (en) | 1998-10-22 |
JP2816326B2 (ja) | 1998-10-27 |
WO1991005552A1 (en) | 1991-05-02 |
JPH0925263A (ja) | 1997-01-28 |
DE69012138T2 (de) | 1995-04-06 |
US5405874A (en) | 1995-04-11 |
AU692197B2 (en) | 1998-06-04 |
JP2975587B2 (ja) | 1999-11-10 |
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