ES2042384A1 - Procedimiento para obtener derivados bis-piridimicos. - Google Patents
Procedimiento para obtener derivados bis-piridimicos.Info
- Publication number
- ES2042384A1 ES2042384A1 ES919102873A ES9102873A ES2042384A1 ES 2042384 A1 ES2042384 A1 ES 2042384A1 ES 919102873 A ES919102873 A ES 919102873A ES 9102873 A ES9102873 A ES 9102873A ES 2042384 A1 ES2042384 A1 ES 2042384A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridinic
- derivatives
- inhibiting properties
- producing bis
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER DERIVADOS BIS-PIRIDINICOS DE FORMULAS: OJO FORMULA DONDE R ES HIDROGENO, ALQUILO, M, N, P Y Q VALEN 0-3, X E Y SON PUENTES DE CONEXION INDEPENDIENTES O UNIDOS ENTRE SI, Y OJO FORMULA SIENDO RSI1 SC HIDROGENO, HALOGENO, ALCOXI O ALQUILO. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA: OJO FORMULA DONDE LOS SIMBOLOS SIGNIFICAN LO MISMO QUE ANTES, CON UN AMINONITRILO DE FORMULA: OJO FORMULA DONDE LOS SIMBOLOS SIGNIFICAN LO MISMO QUE ANTES, EN PRESENCIA DE UN DISOLVENTE Y UN ACIDO DE LEWIS, A UNA TEMPERATURA DE 0-150GC DURANTE 1-48 HORAS, ALQUILAR O ARALQUILAR LOS COMPUESTOS OBTENIDOS EN QUE R ES HIDROGENO, Y TRANSFORMAR EVENTUALMENTE ESTOS COMPUESTOS EN SUS SALES DE ADICION DE ACIDO. LOS COMPUESTOS OBTENIDOS SON UTILES PARA TRATAR LA DEMENCIA SENIL, LA ENFERMEDAD DE ALZHEIMER Y OTRAS DISFUNCIONES DE LA MEMORIA.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102873A ES2042384B1 (es) | 1991-12-26 | 1991-12-26 | Procedimiento para obtener derivados bis-piridinicos. |
AU32589/93A AU3258993A (en) | 1991-12-26 | 1992-12-24 | Method for producing BIS-pyridinic derivatives with acetylcholinesterase inhibiting properties |
PCT/ES1992/000086 WO1993013100A1 (es) | 1991-12-26 | 1992-12-24 | Procedimiento para la obtencion de derivados bis-piridinicos con propiedades inhibidoras de la acetilcolinesterasa |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102873A ES2042384B1 (es) | 1991-12-26 | 1991-12-26 | Procedimiento para obtener derivados bis-piridinicos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2042384A1 true ES2042384A1 (es) | 1993-12-01 |
ES2042384B1 ES2042384B1 (es) | 1994-06-01 |
Family
ID=8274596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9102873A Expired - Lifetime ES2042384B1 (es) | 1991-12-26 | 1991-12-26 | Procedimiento para obtener derivados bis-piridinicos. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3258993A (es) |
ES (1) | ES2042384B1 (es) |
WO (1) | WO1993013100A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2100129B1 (es) * | 1995-10-11 | 1998-02-16 | Medichem Sa | Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion. |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
EP2533645B1 (en) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
CN104853755B (zh) | 2012-12-13 | 2017-08-22 | H.隆德贝克有限公司 | 包含沃替西汀和多奈哌齐的组合物 |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
EP2968220B1 (en) | 2013-03-15 | 2021-05-05 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
EP0287977A2 (en) * | 1987-04-23 | 1988-10-26 | Hoechst-Roussel Pharmaceuticals Incorporated | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments |
EP0394950A1 (en) * | 1989-04-25 | 1990-10-31 | Sumitomo Pharmaceuticals Company, Limited | Pyridine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL87861A0 (en) * | 1987-10-05 | 1989-03-31 | Pfizer | 4-aminopyridine derivatives |
-
1991
- 1991-12-26 ES ES9102873A patent/ES2042384B1/es not_active Expired - Lifetime
-
1992
- 1992-12-24 WO PCT/ES1992/000086 patent/WO1993013100A1/es active Application Filing
- 1992-12-24 AU AU32589/93A patent/AU3258993A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0268871A1 (en) * | 1986-10-31 | 1988-06-01 | Sumitomo Pharmaceuticals Company, Limited | Quinoline derivatives |
EP0287977A2 (en) * | 1987-04-23 | 1988-10-26 | Hoechst-Roussel Pharmaceuticals Incorporated | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments |
EP0394950A1 (en) * | 1989-04-25 | 1990-10-31 | Sumitomo Pharmaceuticals Company, Limited | Pyridine derivatives |
Also Published As
Publication number | Publication date |
---|---|
WO1993013100A1 (es) | 1993-07-08 |
AU3258993A (en) | 1993-07-28 |
ES2042384B1 (es) | 1994-06-01 |
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