ES2039845T3 - Un procedimiento para preparar nuevos derivados azaciclicos. - Google Patents
Un procedimiento para preparar nuevos derivados azaciclicos.Info
- Publication number
- ES2039845T3 ES2039845T3 ES198989301256T ES89301256T ES2039845T3 ES 2039845 T3 ES2039845 T3 ES 2039845T3 ES 198989301256 T ES198989301256 T ES 198989301256T ES 89301256 T ES89301256 T ES 89301256T ES 2039845 T3 ES2039845 T3 ES 2039845T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- group
- alkyl
- azaciclic
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 POLYMETHYLENE Polymers 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Photoreceptors In Electrophotography (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
UN COMPUESTO, O UN SOLVATO O SAL DE ESTO, DE FORMULA (I), EN LA QUE R1 Y R2 SON INDEPENDIENTEMENTE HIDROGENO, C1-6 ALQUILO, C2-6 ALQUENILO, C3-6 CICLOALQUILO O C4-12 CICLOALQUILALQUILO, O JUNTOS FORMAN UN POLIMETILENO C2-8 LINEAL O RAMIFICADO, O UN GRUPO C2-6 ALQUENILENO OPCIONALMENTE SUSTITUIDO CON UN HETEROATOMO, SIEMPRE QUE R1 Y R2 NO SEAN SIMULTANEAMENTE HIDROGENO; R3 ES HIDROGENO, C1-6 ALQUILO, PREFERIBLEMENTE METILO O ETILO, O FENILO, O R3 JUNTO CON R1 FORMA UN GRUPO - (CH2)3 - O - (CH2)4 - P ES 1, 2, 3, 4 Y R ES UN GRUPO DE FORMULA (II), EN LA QUE EL GRUPO - (CHR4)N - X - ESTA EN POSICION META O PARA CON RESPECTO A YR5 O R6, R4 ES HIDROGENO O C1-6 ALQUILO, PREFERIBLEMENTE HIDROGENO; N ES 0,1 O 2 PREFERIBLEMENTE 1; X ES UN ENLACE DIRECTO O O, S O NRA EN LA QUE RA ES HIDROGENO O C1-6 ALQUILO Y ES PREFERIBLEMENTE UN ENLACE DIRECTO; Y ES >C = 0. >CHOH, - S = 0 O - SO2. EL COMPUESTO ES UTIL EN EL TRATAMIENTO DEL DOLOR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888803259A GB8803259D0 (en) | 1988-02-12 | 1988-02-12 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2039845T3 true ES2039845T3 (es) | 1993-10-01 |
Family
ID=10631593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198989301256T Expired - Lifetime ES2039845T3 (es) | 1988-02-12 | 1989-02-09 | Un procedimiento para preparar nuevos derivados azaciclicos. |
Country Status (14)
Country | Link |
---|---|
US (1) | US4994450A (es) |
EP (1) | EP0333315B1 (es) |
JP (1) | JPH01246258A (es) |
KR (1) | KR890012963A (es) |
AT (1) | ATE64391T1 (es) |
AU (1) | AU615984B2 (es) |
DE (1) | DE68900113D1 (es) |
DK (1) | DK65489A (es) |
ES (1) | ES2039845T3 (es) |
GB (1) | GB8803259D0 (es) |
GR (1) | GR3002230T3 (es) |
NZ (1) | NZ227930A (es) |
PT (1) | PT89677A (es) |
ZA (1) | ZA891052B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0232612B1 (en) * | 1985-12-23 | 1990-04-04 | Dr. Lo. Zambeletti S.p.A. | Azacyclic compounds, processes for their preparation, and their use as pharmaceuticals |
US5512567A (en) * | 1988-08-24 | 1996-04-30 | Sankyo Company, Limited | Analgesic compounds, their preparation, and pharmaceutical compositions containing them |
DE68924751T2 (de) * | 1988-09-26 | 1996-04-11 | Smithkline Beecham Farma | Azacyclische Verbindungen, verwendbar als Arzneimittel. |
GB8926560D0 (en) * | 1989-11-24 | 1990-01-17 | Zambeletti Spa L | Pharmaceuticals |
EP0447704A1 (en) * | 1990-03-21 | 1991-09-25 | Smithkline Beecham Farmaceutici S.p.A. | N-Acylated azacyclic compounds, processes for their preparations and their use as medications |
WO1991017116A1 (en) * | 1990-04-28 | 1991-11-14 | Dr. Lo. Zambeletti S.P.A. | Novel 1-(2h-1-oxo-3,4-dihydronaphtyl-6)-acetyl-piperidines, process for their preparation and therapeutic use |
GB9011656D0 (en) * | 1990-05-24 | 1990-07-11 | Zambeletti Spa L | Novel compounds |
EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN105299030B (zh) * | 2015-11-23 | 2018-03-23 | 荣腾实业(苏州)有限公司 | 一种驱动轴导向机构 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052311A1 (en) * | 1980-11-19 | 1982-05-26 | Sterling Drug Inc. | 1-((Benzoylphenyl) - lower-alkyl) piperidines and carbinol analogs and preparation thereof |
US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
DE3409237A1 (de) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
EP0232612B1 (en) * | 1985-12-23 | 1990-04-04 | Dr. Lo. Zambeletti S.p.A. | Azacyclic compounds, processes for their preparation, and their use as pharmaceuticals |
DE3782191T2 (de) * | 1986-06-05 | 1993-02-25 | Ici America Inc | Difluorketoverbindungen. |
DE3767816D1 (de) * | 1986-09-02 | 1991-03-07 | Zambeletti Spa L | 1-acylsubstituierte piperidinderivate. |
DK674487A (da) * | 1986-12-22 | 1988-06-23 | Zambeletti Spa L | Piperidinderivater |
-
1988
- 1988-02-12 GB GB888803259A patent/GB8803259D0/en active Pending
-
1989
- 1989-02-09 ES ES198989301256T patent/ES2039845T3/es not_active Expired - Lifetime
- 1989-02-09 DE DE8989301256T patent/DE68900113D1/de not_active Expired - Fee Related
- 1989-02-09 EP EP89301256A patent/EP0333315B1/en not_active Expired - Lifetime
- 1989-02-09 AT AT89301256T patent/ATE64391T1/de active
- 1989-02-10 NZ NZ227930A patent/NZ227930A/en unknown
- 1989-02-10 PT PT89677A patent/PT89677A/pt not_active Application Discontinuation
- 1989-02-10 DK DK065489A patent/DK65489A/da not_active Application Discontinuation
- 1989-02-10 US US07/309,687 patent/US4994450A/en not_active Expired - Fee Related
- 1989-02-10 AU AU29834/89A patent/AU615984B2/en not_active Ceased
- 1989-02-10 ZA ZA891052A patent/ZA891052B/xx unknown
- 1989-02-11 KR KR1019890001604A patent/KR890012963A/ko not_active Application Discontinuation
- 1989-02-13 JP JP1031285A patent/JPH01246258A/ja active Pending
-
1991
- 1991-07-02 GR GR91400933T patent/GR3002230T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA891052B (en) | 1991-03-27 |
US4994450A (en) | 1991-02-19 |
AU615984B2 (en) | 1991-10-17 |
DK65489D0 (da) | 1989-02-10 |
EP0333315A1 (en) | 1989-09-20 |
DE68900113D1 (de) | 1991-07-18 |
KR890012963A (ko) | 1989-09-20 |
EP0333315B1 (en) | 1991-06-12 |
GR3002230T3 (en) | 1992-12-30 |
JPH01246258A (ja) | 1989-10-02 |
AU2983489A (en) | 1989-08-17 |
GB8803259D0 (en) | 1988-03-09 |
DK65489A (da) | 1989-08-13 |
ATE64391T1 (de) | 1991-06-15 |
PT89677A (pt) | 1989-10-04 |
NZ227930A (en) | 1992-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2039845T3 (es) | Un procedimiento para preparar nuevos derivados azaciclicos. | |
MX9301457A (es) | Agentes antifungicos de peptidos ciclicos y proceso para su preparacion. | |
SE8202166L (sv) | Terapeutiska medel | |
ES2085259T3 (es) | Uso de ciertos antagonistas del receptor 5-ht3 en el tratamiento del dolor visceral. | |
GR3017213T3 (en) | Heterocyclic derivatives. | |
FI901645A0 (fi) | Menetelmä terapeuttisesti aktiivisten interfenyleeni-7-oksabisykloheptyylisubstituoitujen heterosyklisten amidiprostaglandiinianalogien valmistamiseksi | |
ES545330A0 (es) | Un procedimiento para preparar derivados de 1,3-difosfonato | |
DE3380350D1 (en) | Hydroxyalkynyl-azolyl derivatives, process for their preparation and their use as fungicides | |
ATE42281T1 (de) | Verbindungen verwendbar als zwischenprodukte oder ausgangsstoffe zur herstellung von therapeutisch verwendbaren phenyl-azacycloalkanen. | |
MX11866A (es) | Nuevas cicloalquilamidas y procedimiento para su preparacion. | |
MX168469B (es) | Procedimiento para la preparacion de derivados aminoalcoholes acilados | |
ES2035915T3 (es) | Agentes antiarritmicos n-fenetil-aminoalquil-benzamida. | |
DK560182A (da) | Fremgangsmaade til fremstilling af p-substituerede 3-fenoxy-1-karbonylaminoalkylaminopropanol-2-er | |
ES536218A0 (es) | Procedimiento para la obtencion de derivados de hidroxietilazoliloxima | |
DK544689D0 (da) | Terapeutisk aktive forbindelser | |
NO167575C (no) | N-alkyl(en)-n-(o,o-disubstituert-thiofosforyl)-n',n'-disubstituerte-glycinamider, preparater derav med acaricid, insekticid og fungicid virkning, samt fremgangsmaate for kontroll av skadedyr og bekjempelse av sopp. | |
GR3005138T3 (es) | ||
FR2558161B1 (fr) | 3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique | |
ES494257A0 (es) | Procedimiento para la preparacion de una peptidamida | |
DE68918726D1 (de) | Isocarbacyclinderivate enthaltende Antidiabetika. | |
IT1213219B (it) | Derivati amminoalchilnaftalenici ad attivita' farmacologica. | |
FI871253A0 (fi) | 1-/3-(2-dialkylaminoetoxi)-2 -tienyl/-3-fenyl-1-propanoner och deras syraadditionssalter, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska sammansaettningar. | |
GB2006196A (en) | Phenylacetamides with analgesic activity | |
ES554301A0 (es) | Procedimiento de preparar compuestos amidicos farmacologicamente activos | |
ZA897953B (en) | Branched-chain alkyl esters of 2-(4-(2-piperidino-ethoxy)-benzolyl)-benzoic acid,processes for their preparation and their use as spasmolytic agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 333315 Country of ref document: ES |