ES2039161B1 - PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. - Google Patents
PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY.Info
- Publication number
- ES2039161B1 ES2039161B1 ES9200051A ES9200051A ES2039161B1 ES 2039161 B1 ES2039161 B1 ES 2039161B1 ES 9200051 A ES9200051 A ES 9200051A ES 9200051 A ES9200051 A ES 9200051A ES 2039161 B1 ES2039161 B1 ES 2039161B1
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- procedure
- compound
- antiproliferative activity
- obtaining new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE NUEVAS HIDRAZONAS CON ACTIVIDAD ANTIPROLIFERATIVA. COMPRENDE: HACER REACCIONAR UN COMPUESTO DE FORMULA II CON UN COMPUESTO DE FORMULA III, EN UN DISOLVENTE, EN PRESENCIA OPCIONAL DE UN CATALIZADOR Y A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DEL DISOLVENTE, PARA OBTENER UN COMPUESTO DE FORMULA I. EN DICHAS FORMULAS X ES H, OH O OCHSI3 SC; Y ES H, OH O OCHSI3 SC, Z ES H, CHSI3 SC, CSI2 SCHSI5 SC U OTRO ALQUILO DE BAJO PESO MOLECULAR; Y R ES UN GRUPO ALQUILO LINEAL O CICLICO QUE PUEDE ESTAR SUSTITUIDO, UN GRUPO ARILO O ARILO SUSTITUIDO O UN GRUPO HETEROCICLICO. LOS COMPUESTOS DE FORMULA I TIENEN APLICACION COMO INHIBIDORES DE LA PROLIFERACION CELULAR Y, MAS CONCRETAMENTE, TIENEN APLICACION EN LA TERAPIA DEL CANCER Y EN EL TRATAMIENTO DE LA ARTERIOESCLEROSIS.PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. IT INCLUDES: REACTING A COMPOUND OF FORMULA II WITH A COMPOUND OF FORMULA III, IN A SOLVENT, IN THE OPTIONAL PRESENCE OF A CATALYST AND AT A TEMPERATURE COMPRISED BETWEEN THE ENVIRONMENT AND THE REFLUX OF THE SOLVENT, TO OBTAIN A COMPOUND OF SOLVENT I. FORMULAS X ES H, OH OR OCHSI3 SC; Y IS H, OH OR OCHSI3 SC, Z IS H, CHSI3 SC, CSI2 SCHSI5 SC OR ANOTHER LOW MOLECULAR WEIGHT ALKYL; AND R IS A LINEAR OR CYCLIC ALKYL GROUP THAT MAY BE SUBSTITUTED, A GROUP ARILO OR ARILO SUBSTITUTED OR A HETEROCICLICO GROUP. FORMULA I COMPOUNDS HAVE APPLICATION AS INHIBITORS OF CELL PROLIFERATION AND, MORE SPECIFICALLY, HAVE APPLICATION IN CANCER THERAPY AND IN THE TREATMENT OF ARTERIOSCLEROSIS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9200051A ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9200051A ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2039161A1 ES2039161A1 (en) | 1993-08-16 |
ES2039161B1 true ES2039161B1 (en) | 1994-04-01 |
Family
ID=8275718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9200051A Expired - Fee Related ES2039161B1 (en) | 1992-01-13 | 1992-01-13 | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2039161B1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10338673A (en) * | 1997-06-04 | 1998-12-22 | Nippon Bayeragrochem Kk | Isonicotinic acid hydrazide derivative and pest controlling agent |
AU3166299A (en) * | 1998-04-09 | 1999-11-01 | Eisai Co. Ltd. | Arginine peptide analogs useful as fibroblast growth factor antagonists |
WO2002089745A2 (en) * | 2001-05-10 | 2002-11-14 | Cytovia, Inc. | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
KR20170141542A (en) * | 2016-06-15 | 2017-12-26 | 국립암센터 | Pharmaceutical composition of RHOA inhibitor to prevent and treat gastric cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES490004A0 (en) * | 1980-03-27 | 1981-04-01 | Barisintex Sa | PROCEDURE FOR THE PREPARATION OF AROMATIC ALDEHYDE ALCOXYCARBONYL HYDRAZONES |
WO1988008836A2 (en) * | 1987-05-15 | 1988-11-17 | Schering Corporation | Aryl substituted naphthalene, benzoxepine, benzazepine, benzocycloheptene derivatives |
DE3903990A1 (en) * | 1989-02-10 | 1990-08-30 | Basf Ag | PHENYL HYDRAZONE, THEIR MANUFACTURE, AND MEDICAMENTS AND COSMETICS PRODUCED FROM THEM |
-
1992
- 1992-01-13 ES ES9200051A patent/ES2039161B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2039161A1 (en) | 1993-08-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES551531A0 (en) | PROCEDURE TO DETECT HYDROGEN PEROXIDE OR HYDROGEN PEROXIDE FORMING SUBSTANCES | |
ES2168737T3 (en) | INHIBITORS OF NITRICO SINTASA OXIDE. | |
ES2083941T3 (en) | PRODUCT FOR OXIDATIVE HAIR DYEING BASED ON 4,5-DIAMINO-PIRAZOLES AND M-FENILEN-DIAMINE DERIVATIVES. | |
DK99691D0 (en) | DOPAMINE-BETA-HYDROXYLASE INHIBITORS AND PROCEDURE FOR THEIR PREPARATION | |
ES2058093T3 (en) | SUBSTITUTED HERBICIDAL AND FUNGICIDAL AGENTS BASED ON PIRAZOLIN-5-ONA DERIVATIVES. | |
ES2056783T3 (en) | SUBSTITUTED DERIVATIVES OF BENZOIC ACID WITH CARDIOVASCULAR ACTIVITY. | |
ES2036852T3 (en) | PROCEDURE FOR THE OBTAINING OF TRIFLUORMETILFENIL-AZOLILMETILOXIRANOS AND ITS USE AS PROTECTING AGENTS OF PLANTS. | |
ES547826A0 (en) | A PROCEDURE FOR PREPARING NEW DERIVATIVES OF 6- (4-PHENYL SUBSTITUTED -3 (2H) PIRADAZINONE. | |
ES391026A1 (en) | Benzonaphthyridine derivatives | |
ES510585A0 (en) | PROCEDURE FOR PREPARING N-HETEROCICLILMETILAMIDAS. | |
MX9304399A (en) | NOVEL PROCESS TO PREPARE [[2-BROMOETHYL) -AMINO] METHYL] -2-NITRO-1H-IMIDAZOL-1-ETHANOL CHIRAL AND RELATED COMPOUNDS. | |
ES2039161B1 (en) | PROCEDURE FOR OBTAINING NEW HYDRAZONES WITH ANTIPROLIFERATIVE ACTIVITY. | |
ES393738A1 (en) | N-(1-bicyclic aryl-propyl-2)-n'-bicyclic aryl-piperazines | |
FR2383185A1 (en) | ||
ES424483A1 (en) | Hererocyclic derivatives of a guanidine | |
ATE69050T1 (en) | ORGANIC COMPOUNDS AND THEIR PHARMACEUTICAL USE. | |
ES2082894T3 (en) | DIHYDROPIRIDE (4,3-D) PIRIMIDINES 4-SUBSTITUTED AS ANALGESICS AND TOPIC ANTI-INFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISEASES. | |
MX9204138A (en) | DITIANE COMPOUNDS, PROCEDURE FOR THEIR OBTAINING AND CONTAINING MEDICINES | |
ES2062407T3 (en) | 2-HYDROXY-3-PHENOXYPROPYLAMINE COMPOUNDS. | |
DK471979A (en) | ESTERS OF 1,1,2-TRIPHENYL ALKENE DERIVATIVES | |
AR002749A1 (en) | DERIVATIVES OF ESTIRIL BENCIMIDAZOLE AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM. | |
ES2080559T3 (en) | PROCEDURE FOR OBTAINING AMINOPROPIONITRILS. | |
ES433133A1 (en) | Derivatives of 1-phenoxy-3-aminopropan-2-ol and processes for their preparation | |
FR2426046A1 (en) | TETRAHYDRO-ISOQUINOLEINE DERIVATIVE, ITS PREPARATION AND THERAPEUTIC APPLICATION | |
ES2043778T3 (en) | PROCEDURE TO PREPARE OXIINDANES AND TETRAHIDRONAFTALENOS HERBICIDES. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041004 |