ES2038204T3 - Procedimiento para la preparacion de productos intermedios de carbaciclina opticamente activos. - Google Patents

Procedimiento para la preparacion de productos intermedios de carbaciclina opticamente activos.

Info

Publication number
ES2038204T3
ES2038204T3 ES198787730143T ES87730143T ES2038204T3 ES 2038204 T3 ES2038204 T3 ES 2038204T3 ES 198787730143 T ES198787730143 T ES 198787730143T ES 87730143 T ES87730143 T ES 87730143T ES 2038204 T3 ES2038204 T3 ES 2038204T3
Authority
ES
Spain
Prior art keywords
pct
optically active
intermediate products
carbacicline
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787730143T
Other languages
English (en)
Inventor
Werner Dr. Skuballa
Helmut Dr. Dahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2038204T3 publication Critical patent/ES2038204T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA OBTENCION DE CIS-BICICLO [3,3,0] OCTANO-2-ALDEHIDOS DE FORMULA (I), DONDE R1 Y R2 JUNTOS SIGNIFICAN EL RESTO O-X-O UNIDO EN 2 CON X COMO ALQUILOS DE CADENA RECTA O RAMIFICADOS CON 1-7 ATOMOS DE CARBONO Y R3 ES HIDROGENO, UN RESTO ALQUILO SATURADO CON 1 A 7 ATOMOS DE C, UN RESTO ARALQUILO CON 7-10 ATOMOS DE C, UN RESTO TETRAHIDROPIRANILO, UN RESTO TRIALQUILSILILO CON 1-6 ATOMOS DE C EN EL ALQUILO, EN DONDE EL ALQUILO TAMBIEN PUEDE SUSTITUIRSE CON FENILO, UN RESTO DIALQUILFENILSILILO O ALQUILDIFENILSILILO CON 1-6 ATOMOS DE C EN EL ALQUILO, QUE SEPARA LA AMIDAS DIASTEREOISOMERAS DE LA FORMULA (II) DONDE R1, R2 Y R3 TIENEN EL SIGNIFICADO DE MAS ARRIBA, Y REDUCE LA AMIDA DE LA FORMULA (II) ENANTIOMERICAMENTE PURA.
ES198787730143T 1986-11-13 1987-11-12 Procedimiento para la preparacion de productos intermedios de carbaciclina opticamente activos. Expired - Lifetime ES2038204T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863638757 DE3638757A1 (de) 1986-11-13 1986-11-13 Neues verfahren zur herstellung von optisch aktiven carbacyclin-zwischenstufen

Publications (1)

Publication Number Publication Date
ES2038204T3 true ES2038204T3 (es) 1993-07-16

Family

ID=6313857

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787730143T Expired - Lifetime ES2038204T3 (es) 1986-11-13 1987-11-12 Procedimiento para la preparacion de productos intermedios de carbaciclina opticamente activos.

Country Status (10)

Country Link
US (1) US4925956A (es)
EP (1) EP0270481B1 (es)
JP (1) JPH01501229A (es)
AT (1) ATE62671T1 (es)
AU (1) AU611403B2 (es)
DE (2) DE3638757A1 (es)
ES (1) ES2038204T3 (es)
GR (1) GR3001818T3 (es)
HU (1) HU202240B (es)
WO (1) WO1988003526A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835162A1 (de) * 1988-10-13 1990-04-19 Schering Ag (1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
US7417981B2 (en) * 2003-10-15 2008-08-26 Vonage Holdings Corp. Method and apparatus for enhanced Internet Telephony

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891676A (en) * 1972-09-20 1975-06-24 Merck & Co Inc 2-Alpha-carboxy-3-alpha(hydroxyethyl)-5-oxocyclopentane derivatives
DE3638761A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verbesserte ketoreduktion von carbacyclinzwischenprodukten

Also Published As

Publication number Publication date
WO1988003526A1 (en) 1988-05-19
JPH01501229A (ja) 1989-04-27
DE3638757A1 (de) 1988-05-26
AU8274987A (en) 1988-06-01
EP0270481A1 (de) 1988-06-08
AU611403B2 (en) 1991-06-13
US4925956A (en) 1990-05-15
ATE62671T1 (de) 1991-05-15
HU202240B (en) 1991-02-28
DE3769442D1 (de) 1991-05-23
EP0270481B1 (de) 1991-04-17
GR3001818T3 (en) 1992-11-23
HUT47095A (en) 1989-01-28

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