ES2038171T3 - Sintesis de 2-aminopirimidinas (4,5-g)-quinolinas. - Google Patents

Sintesis de 2-aminopirimidinas (4,5-g)-quinolinas.

Info

Publication number
ES2038171T3
ES2038171T3 ES198787302662T ES87302662T ES2038171T3 ES 2038171 T3 ES2038171 T3 ES 2038171T3 ES 198787302662 T ES198787302662 T ES 198787302662T ES 87302662 T ES87302662 T ES 87302662T ES 2038171 T3 ES2038171 T3 ES 2038171T3
Authority
ES
Spain
Prior art keywords
methyl
ethyl
phenyl
chem
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787302662T
Other languages
English (en)
Inventor
Leland Otto Weigel
Gilbert Stanley Staten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2038171T3 publication Critical patent/ES2038171T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)

Abstract

ESTA INVENCION OFRECE UN PROCEDIMIENTO PARA OBTENER TRANS 2-AMINOPIRIMIDIN [4,5-G] QIONOLEINAS DE FORMULA (I) DONDE R ES HIDROGENO, CIANO, ALQUILO O ALILO C1-C3; R1 ES AMINO, -NHR3 O -NR4R5; R2 ES HIDROGENO O METILO; R3 ES METILO, ETILO, N-PROPILO, ALQUIL-CO CON C1-C3, FENIL-CO O FENIL-CO SUSTITUIDO, DONDE DICHOS SUSTITUYENTES SON 1 O 2 MIEMBROS SELECCIONADOS ENTRE EL GRUPO FORMADO POR CLORO, FLUOR, BROMO, METILO, ETILO, METOXI, ETOXI Y TRIFLUOROMETILO; Y R4 Y R5 SON INDIVIDUALMENTE METILO, ETILO O N-PROPILO. EL PROCESO CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) DONDE R6 ES ALQUILO C1-C3, FENILO, 4-CLOROFENILO, 4-BROMOFENILO O 4-METILFENILO CON UNA SAL DE GUANIDINA. LOS COMPUESTOS SON AGONISTAS DE LA DOPAMINA.
ES198787302662T 1986-03-31 1987-03-27 Sintesis de 2-aminopirimidinas (4,5-g)-quinolinas. Expired - Lifetime ES2038171T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/845,916 US4764609A (en) 1986-03-31 1986-03-31 Synthesis of 2-aminopyrimido[4,5-g]quinolines

Publications (1)

Publication Number Publication Date
ES2038171T3 true ES2038171T3 (es) 1993-07-16

Family

ID=25296418

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787302662T Expired - Lifetime ES2038171T3 (es) 1986-03-31 1987-03-27 Sintesis de 2-aminopirimidinas (4,5-g)-quinolinas.

Country Status (20)

Country Link
US (1) US4764609A (es)
EP (1) EP0241186B1 (es)
JP (1) JPS62240684A (es)
KR (1) KR890003162B1 (es)
CN (1) CN1016176B (es)
AT (1) ATE53584T1 (es)
AU (1) AU584286B2 (es)
CA (1) CA1289955C (es)
DE (1) DE3763193D1 (es)
DK (1) DK161287A (es)
EG (1) EG18298A (es)
ES (1) ES2038171T3 (es)
GR (1) GR3000644T3 (es)
HU (1) HU196402B (es)
IL (1) IL82027A0 (es)
NZ (1) NZ219810A (es)
PH (1) PH23682A (es)
PT (1) PT84579B (es)
SU (1) SU1676450A3 (es)
ZA (1) ZA872278B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4831145A (en) * 1986-03-31 1989-05-16 Eli Lilly And Company 7-phenylsulfonyloxymethylene-6-oxo-perhydroquinolines
US5998414A (en) * 1996-08-22 1999-12-07 Hoechst Marion Roussel, Inc. Troponyl piperazines as dopamine D4 receptor ligands
DE102008061012A1 (de) * 2008-11-24 2010-05-27 Siemens Aktiengesellschaft Verfahren und Vorrichtung zum Transportieren eines Gegenstands an eine unvollständig angegebene Zieladresse

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD62062A (es) *
US3984473A (en) * 1968-10-04 1976-10-05 Hoffmann-La Roche Inc. Stereospecific total steroidal synthesis via substituted C/D-trans indanones
US4238623A (en) * 1976-03-29 1980-12-09 Miles Laboratories, Inc. 5,6-Benzo analogues of prostaglandin
US4230861A (en) * 1979-01-22 1980-10-28 Eli Lilly And Company 1-And/or 7-substituted-6-hydroxy (or oxo)-3-decahydroquinoline carboxylic acids
US4540787A (en) * 1982-06-03 1985-09-10 Eli Lilly And Company Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines
US4443605A (en) * 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4471121A (en) * 1982-11-03 1984-09-11 Eli Lilly And Company Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof
ES524453A0 (es) * 1982-11-03 1984-12-01 Lilly Co Eli Un procedimiento para la obtencion de un tautomero de pirazoloquinolinas
DE3247926A1 (de) * 1982-12-24 1984-06-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2-alkylthiomethyl-4-hydroxypyrimidinen
SE8302361D0 (sv) * 1983-04-27 1983-04-27 Astra Laekemedel Ab New tricyclic amines
US4501890A (en) * 1983-09-26 1985-02-26 Eli Lilly And Company Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
RO89126A (ro) * 1983-09-26 1986-04-30 Eli Lilly And Co,Us Procedeu de preparare a unor derivati de chinolina
US4507478A (en) * 1983-09-26 1985-03-26 Eli Lilly And Company 2-Mercaptopyrimidohexahydroquinolines and related compounds
JPH084081A (ja) * 1994-06-21 1996-01-09 Inax Corp サービスタンク装置
US5752246A (en) * 1995-06-07 1998-05-12 International Business Machines Corporation Service agent for fulfilling requests of a web browser

Also Published As

Publication number Publication date
KR870008884A (ko) 1987-10-21
JPS62240684A (ja) 1987-10-21
AU7077687A (en) 1987-10-08
PT84579B (pt) 1989-11-30
EP0241186B1 (en) 1990-06-13
GR3000644T3 (en) 1991-09-27
HU196402B (en) 1988-11-28
ATE53584T1 (de) 1990-06-15
AU584286B2 (en) 1989-05-18
DK161287A (da) 1987-10-01
DE3763193D1 (de) 1990-07-19
SU1676450A3 (ru) 1991-09-07
NZ219810A (en) 1989-10-27
US4764609A (en) 1988-08-16
IL82027A0 (en) 1987-10-20
PT84579A (en) 1987-04-01
CA1289955C (en) 1991-10-01
DK161287D0 (da) 1987-03-30
CN1016176B (zh) 1992-04-08
CN87102570A (zh) 1987-12-16
KR890003162B1 (ko) 1989-08-25
ZA872278B (en) 1988-10-26
PH23682A (en) 1989-09-27
HUT43606A (en) 1987-11-30
EP0241186A1 (en) 1987-10-14
EG18298A (en) 1992-12-30

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