ES2029880T3 - Dispositivo de liberacion de productos farmaceuticos. - Google Patents

Dispositivo de liberacion de productos farmaceuticos.

Info

Publication number
ES2029880T3
ES2029880T3 ES198888300604T ES88300604T ES2029880T3 ES 2029880 T3 ES2029880 T3 ES 2029880T3 ES 198888300604 T ES198888300604 T ES 198888300604T ES 88300604 T ES88300604 T ES 88300604T ES 2029880 T3 ES2029880 T3 ES 2029880T3
Authority
ES
Spain
Prior art keywords
polar
release device
pharmaceutical products
pharmaceutically active
drug component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888300604T
Other languages
English (en)
Inventor
Louis Michel Jacques Aguadisch
Frank Syms Rankin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Silicones UK Ltd
Original Assignee
Dow Corning Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Corning Ltd filed Critical Dow Corning Ltd
Application granted granted Critical
Publication of ES2029880T3 publication Critical patent/ES2029880T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/70—Siloxanes defined by use of the MDTQ nomenclature

Abstract

DISPOSITIVOS MEJORADOS PARA LIBERAR PRODUCTOS FARMACEUTICOS QUE PUEDEN LIBERAR MATERIALES FARMACEUTICAMENTE ACTIVOS HIDROFILOS O POLARES, Y OPCIONALMENTE TAMBIEN MATERIALES HIDROFOBOS O NO-POLARES, QUE TIENEN PEQUEÑAS PARTICULAS CON UN DIAMETRO MEDIO DE ALREDEDOR DE 20 MICRAS DE UN COMPONENTE FARMACEUTICO QUE CONTIENE MATERIAL HIDROFILO O POLAR FARMACEUTICAMENTE ACTIVO, DISPERSO EN UNA MATRIZ DE SILICONA. ESTOS DISPOSITIVOS SE PRODUCEN USANDO CIERTOS COPOLIMEROS DE POLIORGANOSILOXANOPOLIOXIALQUILENO. PREFERIBLEMENTE SE PREPARA UNA EMULSION DEL COMPONENTE FARMACEUTICAMENTE ACTIVO EN UNA COMPOSICION QUE CONTIENE SILICONA, ANTES DEL CURADO DE LA COMPOSICION PARA DAR UN PRODUCTO ELASTOMERO.
ES198888300604T 1987-02-28 1988-01-26 Dispositivo de liberacion de productos farmaceuticos. Expired - Lifetime ES2029880T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878704755A GB8704755D0 (en) 1987-02-28 1987-02-28 Pharmaceutical delivery device

Publications (1)

Publication Number Publication Date
ES2029880T3 true ES2029880T3 (es) 1992-10-01

Family

ID=10613125

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888300604T Expired - Lifetime ES2029880T3 (es) 1987-02-28 1988-01-26 Dispositivo de liberacion de productos farmaceuticos.

Country Status (13)

Country Link
US (1) US4814184A (es)
EP (1) EP0281236B1 (es)
JP (1) JP2821497B2 (es)
AT (1) ATE66809T1 (es)
AU (1) AU605062B2 (es)
CA (1) CA1323571C (es)
DE (1) DE3864543D1 (es)
DK (1) DK167956B1 (es)
ES (1) ES2029880T3 (es)
FI (1) FI880915A (es)
GB (1) GB8704755D0 (es)
IE (1) IE59099B1 (es)
NO (1) NO880314L (es)

Families Citing this family (34)

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US4898920A (en) * 1987-10-15 1990-02-06 Dow Corning Corporation Adhesive compositions, controlled release compositions and transdermal delivery device
AU3432689A (en) * 1988-03-24 1989-10-16 Bukh Meditec A/S Controlled release composition
US4951657A (en) * 1988-04-22 1990-08-28 Dow Corning Corporation Heat sealable membrane for transdermal drug release
US4892907A (en) * 1988-12-08 1990-01-09 General Electric Company Fast room temperature vulcanizing silicone elastomers
US5441743A (en) * 1988-12-21 1995-08-15 Battelle Memorial Institute Marine compositions bearing preferentially concentrated domains of non-tin, organo anti-fouling agents
US5141748A (en) * 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
FR2648143B1 (fr) * 1989-06-08 1991-09-06 Rhone Poulenc Chimie Composition comprenant un copolymere silicone thermoplastique et un compose de l'iode, utilisable apres sa mise en forme, pour le traitement des eaux
FR2653338B1 (fr) * 1989-10-23 1994-06-10 Dow Corning Sa Formulation pour des pansements a liberation prolongee de medicament et son utilisation.
FR2653337B1 (fr) * 1989-10-23 1992-02-07 Dow Corning Sa Element a liberation prolongee et procede pour le fabriquer.
DE4015543A1 (de) * 1990-05-15 1991-11-21 Bayer Ag Spermicides beschichtungsmittel
US5262087A (en) * 1991-05-01 1993-11-16 Kose Corporation Water-in-oil type emulsified composition
FR2682090B1 (fr) * 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5399342A (en) * 1993-02-03 1995-03-21 Dow Corning Corporation Cosmetics with enhanced durability
EP0688564B1 (en) * 1994-06-20 1999-08-04 Dow Corning Corporation Method of controlling release of an active substance or drug from a silicone rubber matrix
US6056976A (en) * 1998-11-12 2000-05-02 Leiras Oy Elastomer, its preparation and use
US5948855A (en) * 1999-01-12 1999-09-07 Dow Corning Corporation Water-in-oil-in water emulsion
JP4428899B2 (ja) 1999-07-02 2010-03-10 エルテーエス ローマン テラピー−ジステーメ アーゲー ポリシロキサンおよび両親和性溶媒を基にした微小貯蔵所系
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
DE10012908B4 (de) * 2000-03-16 2005-03-17 Lts Lohmann Therapie-Systeme Ag Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung
US7247315B2 (en) * 2001-08-17 2007-07-24 Lavipharm Laboratories Inc. Compositions and medical device for transdermal delivery of a drug and methods of making and using same
GB0125778D0 (en) 2001-10-26 2001-12-19 Procter & Gamble Silicone elastomer emulsion cosmetic composition comprising colorant inclusive internal phase
US7223386B2 (en) 2002-03-11 2007-05-29 Dow Corning Corporation Preparations for topical skin use and treatment
KR101050672B1 (ko) * 2003-04-14 2011-07-19 에르테에스 로만 테라피-시스테메 아게 캅사이신을 포함하는 폴리실록산 기질을 갖는 치료학적반창고
JP5160217B2 (ja) 2004-03-12 2013-03-13 ダウ・コーニング・コーポレイション シリコーンポリエーテルを使用する、親水性薬剤供給用シリコーン感圧接着剤を調製する方法
US9168328B2 (en) * 2005-02-25 2015-10-27 Drexel University Layered manufacturing utilizing foam as a support and multifunctional material for the creation of parts and for tissue engineering
WO2007066339A1 (en) * 2005-12-07 2007-06-14 Ramot At Tel Aviv University Ltd. Drug-delivering composite structures
US8293318B1 (en) 2006-08-29 2012-10-23 Abbott Cardiovascular Systems Inc. Methods for modulating the release rate of a drug-coated stent
JP2009273674A (ja) * 2008-05-15 2009-11-26 Alcare Co Ltd 皮膚用シリコーン系粘着剤、皮膚用シリコーン系貼付材及びその製造方法
WO2009150650A2 (en) * 2008-06-12 2009-12-17 Ramot At Tel Aviv University Ltd. Drug-eluting medical devices
US8562669B2 (en) * 2008-06-26 2013-10-22 Abbott Cardiovascular Systems Inc. Methods of application of coatings composed of hydrophobic, high glass transition polymers with tunable drug release rates
US9484123B2 (en) 2011-09-16 2016-11-01 Prc-Desoto International, Inc. Conductive sealant compositions
US10933011B2 (en) * 2016-03-14 2021-03-02 Dow Silicones Corporation Composition and method of preparation
TW201910435A (zh) * 2017-07-31 2019-03-16 日商道康寧東麗股份有限公司 固化性矽組成物以及光半導體裝置
CA3074636A1 (en) * 2017-09-04 2019-03-07 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an emulsifier

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US3777015A (en) * 1970-01-19 1973-12-04 Alza Corp Device for suppressing fertility
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3909444A (en) * 1971-08-05 1975-09-30 Ncr Co Microcapsule
BE791632A (fr) * 1971-11-20 1973-05-21 Schering Ag Supports a base de caoutchouc siliconique pour agents medicamenteux
US3832458A (en) * 1971-12-06 1974-08-27 River C Foundation Hydrophilic silicone composition and method
US3921636A (en) * 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US3992518A (en) * 1974-10-24 1976-11-16 G. D. Searle & Co. Method for making a microsealed delivery device
US4053580A (en) * 1975-01-01 1977-10-11 G. D. Searle & Co. Microsealed pharmaceutical delivery device
DE2642032A1 (de) * 1976-09-18 1978-03-30 Merck Patent Gmbh Siliciumdioxidhaltige zubereitungen und verfahren zu ihrer herstellung
US4191741A (en) * 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
DE2902414A1 (de) * 1979-01-23 1980-08-07 Hoechst Ag Depotkoerper auf basis silicon- kautschuk sowie verfahren zu seiner herstellung
US4311695A (en) * 1979-12-03 1982-01-19 Dow Corning Corporation Personal-care emulsions comprising a siloxane-oxyalkylene copolymer
JPS5759806A (en) * 1980-08-11 1982-04-10 Searle & Co Nitroglycerine pad for percutaneous administration
US4532132A (en) * 1983-04-11 1985-07-30 Dow Corning Corporation Skin care formulations comprising a water-in-mineral oil emulsion and siloxane compositions therefor
DE3333240A1 (de) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
DE3436177A1 (de) * 1984-10-03 1986-04-03 Goldschmidt Ag Th Verwendung von polyoxyalkylen-polysiloxan-copolymerisaten mit an siliciumatomen gebundenen langkettigen alkylresten als emulgatoren zur herstellung von w/o-emulsionen
US4690683A (en) * 1985-07-02 1987-09-01 Rutgers, The State University Of New Jersey Transdermal varapamil delivery device
FR2611734B1 (fr) * 1987-02-26 1989-06-16 Rhone Poulenc Chimie Composition elastomere silicone polycondensation contenant de l'iode pour le traitement des eaux
FR2611733B1 (fr) * 1987-02-26 1989-06-16 Rhone Poulenc Chimie Composition a base de gomme diorganopolysiloxane contenant de l'iode pour le traitement des eaux
FR2611735B1 (fr) * 1987-02-26 1989-06-16 Rhone Poulenc Chimie Composition elastomere silicone polyaddition contenant de l'iode pour le traitement de l'eau

Also Published As

Publication number Publication date
AU1234988A (en) 1988-09-01
DK167956B1 (da) 1994-01-10
DK102188A (da) 1988-08-29
AU605062B2 (en) 1991-01-03
CA1323571C (en) 1993-10-26
GB8704755D0 (en) 1987-04-01
EP0281236B1 (en) 1991-09-04
NO880314D0 (no) 1988-01-26
NO880314L (no) 1988-08-29
DE3864543D1 (de) 1991-10-10
FI880915A0 (fi) 1988-02-26
EP0281236A3 (en) 1989-06-07
EP0281236A2 (en) 1988-09-07
DK102188D0 (da) 1988-02-26
US4814184A (en) 1989-03-21
JPS63227517A (ja) 1988-09-21
IE880533L (en) 1988-08-28
IE59099B1 (en) 1994-01-12
JP2821497B2 (ja) 1998-11-05
FI880915A (fi) 1988-08-29
ATE66809T1 (de) 1991-09-15

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