ES2029801T3 - Procedimiento para preparar acidos tetrahidro-3-piridina-carboxilicos sustituidos y esteres y amidas de los mismos con actividad colinergica. - Google Patents
Procedimiento para preparar acidos tetrahidro-3-piridina-carboxilicos sustituidos y esteres y amidas de los mismos con actividad colinergica.Info
- Publication number
- ES2029801T3 ES2029801T3 ES198787102216T ES87102216T ES2029801T3 ES 2029801 T3 ES2029801 T3 ES 2029801T3 ES 198787102216 T ES198787102216 T ES 198787102216T ES 87102216 T ES87102216 T ES 87102216T ES 2029801 T3 ES2029801 T3 ES 2029801T3
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- alkyl
- substituted
- cycloalkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A LOS ACIDOS 1,2,3,6-TETRAHIDRO-PIRIDIN-3-CARBOXILICOS, SUS ESTERES Y AMIDAS DE FORMULA ESTRUCTURAL (I):EN LA QUE LAS LINEAS DE PUNTOS INDICAN LA PRESENCIA DE UN SOLO DOBLE ENLACE ENTRE LOS CARBONOS 3 Y 4 O ENTRE LOS CARBONOS 4 Y 5; R1 ES H, ALQUILO DE 1 A 6 C, ALQUENILO DE 2 A 6 C, ALCOXICARBONILO DE 2 A 5 C, CICLOALQUILO DE 4 A 8 C O FENIL-ALQUILO DE 1 A 6 C (PUDIENDO ESTAR EL GRUPO FENILO SUSTITUIDO); R3 REPRESENTA EL GRUPO -COOR EN EL QUE EL RADICAL R PUEDE SER HIDROGENO O DIFERENTES GRUPOS QUE SE MENCIONAN; R4 ES ALQUILO O ALQUENILO DE HASTA 6 C, CICLOALQUILO DE HASTA 8 C, 2- O 3-TIENILO, FENILO O FENILALQUILO DE HASTA 6 C (PUDIENDO TAMBIEN ESTAR SUSTITUIDO EN FENILO), Y A SUS SALES FARMACEUTICAMENTE ACEPTABLES QUE POSEEN ACTIVIDAD DE COMBINACION CON LA MUSCARINA Y TIENEN UTILIDAD PARA EL TRATAMIENTO DE LOS SINTOMAS SENILES DE DISMINUCION DE LA COGNICION. TAMBIEN TRATA LA INVENCION DE FORMULACIONES Y PRODUCTOS FARMACEUTICOS A BASE DE LOS CITADOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/830,035 US4745123A (en) | 1986-02-18 | 1986-02-18 | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2029801T3 true ES2029801T3 (es) | 1992-10-01 |
Family
ID=25256160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787102216T Expired - Lifetime ES2029801T3 (es) | 1986-02-18 | 1987-02-17 | Procedimiento para preparar acidos tetrahidro-3-piridina-carboxilicos sustituidos y esteres y amidas de los mismos con actividad colinergica. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4745123A (es) |
EP (1) | EP0235663B1 (es) |
JP (1) | JPH0832682B2 (es) |
AT (1) | ATE54910T1 (es) |
CA (1) | CA1285939C (es) |
DE (1) | DE3763863D1 (es) |
ES (1) | ES2029801T3 (es) |
GR (1) | GR3000682T3 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2171109A1 (es) * | 1999-02-24 | 2002-08-16 | Hoffmann La Roche | Derivados de 4-fenil-piridina. |
US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446057A (en) * | 1993-09-24 | 1995-08-29 | Warner-Lambert Company | Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists |
US6303790B1 (en) | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
EP1257544B1 (en) * | 2000-02-11 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Piperazine and piperidine derivatives for treatment or prevention of neuronal damage |
TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
WO2005068427A1 (ja) * | 2004-01-14 | 2005-07-28 | Takeda Pharmaceutical Company Limited | カルボキサミド誘導体およびその用途 |
CN101146775B (zh) | 2005-03-23 | 2012-07-18 | 弗·哈夫曼-拉罗切有限公司 | 用于呕吐的用作nk-i拮抗剂的代谢物 |
CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
ES2335922T3 (es) | 2005-09-23 | 2010-04-06 | F.Hoffmann-La Roche Ag | Nueva formulacion de dosificacion. |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
PL2398500T3 (pl) | 2009-02-20 | 2019-09-30 | 2-Bbb Medicines B.V. | System dostarczania leków na bazie glutationu |
KR101741629B1 (ko) | 2009-05-06 | 2017-05-31 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4467095A (en) * | 1969-02-10 | 1984-08-21 | Fmc Corporation | Anticholinergic compounds |
GB1392810A (en) * | 1971-10-29 | 1975-04-30 | Wyeth John & Brother Ltd | Pharmaceutical compositions containing thioamides and nitriles |
US4064253A (en) * | 1973-10-10 | 1977-12-20 | Teng Hian Khoe | Method of suppressing snoring |
US4096268A (en) * | 1974-11-14 | 1978-06-20 | Bayer Aktiengesellschaft | 1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid esters and a method of use for combating insects or acarids |
US4238488A (en) * | 1978-11-17 | 1980-12-09 | Imperial Chemical Industries Limited | Carboxylic acid derivatives of N-substituted benzyl-1,2,5,6-tetrahydropyridines |
US4383999A (en) * | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
-
1986
- 1986-02-18 US US06/830,035 patent/US4745123A/en not_active Expired - Lifetime
-
1987
- 1987-01-28 CA CA000528411A patent/CA1285939C/en not_active Expired - Fee Related
- 1987-02-17 DE DE8787102216T patent/DE3763863D1/de not_active Expired - Fee Related
- 1987-02-17 AT AT87102216T patent/ATE54910T1/de not_active IP Right Cessation
- 1987-02-17 JP JP62032590A patent/JPH0832682B2/ja not_active Expired - Fee Related
- 1987-02-17 ES ES198787102216T patent/ES2029801T3/es not_active Expired - Lifetime
- 1987-02-17 EP EP87102216A patent/EP0235663B1/en not_active Expired - Lifetime
-
1990
- 1990-07-27 GR GR90400541T patent/GR3000682T3/el unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2171109A1 (es) * | 1999-02-24 | 2002-08-16 | Hoffmann La Roche | Derivados de 4-fenil-piridina. |
US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
Also Published As
Publication number | Publication date |
---|---|
ATE54910T1 (de) | 1990-08-15 |
EP0235663B1 (en) | 1990-07-25 |
GR3000682T3 (en) | 1991-09-27 |
JPH0832682B2 (ja) | 1996-03-29 |
EP0235663A1 (en) | 1987-09-09 |
US4745123A (en) | 1988-05-17 |
DE3763863D1 (de) | 1990-08-30 |
JPS62192358A (ja) | 1987-08-22 |
CA1285939C (en) | 1991-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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